MBNL2 muscleblind like splicing regulator 2 [Gallus gallus (chicken)] - Gene

Summary

Symbol: MBNL2provided by CGNC
Full Name: muscleblind like splicing regulator 2provided by CGNC
Primary source: CGNC:50852
See related: Ensembl:ENSGALG00010005272
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	1	NC_052532.1 (145340236..145447360, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	1	NC_052573.1 (145332440..145439495, complement)

Chromosome 1 - NC_052532.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Conserved developmental stage- and tissue-specific alternative splicing of MBNL transcripts is an important mechanism by which MBNL activity is regulated during embryonic development.
Title: Conserved developmental alternative splicing of muscleblind-like (MBNL) transcripts regulates MBNL localization and activity.
MBNL2 mRNAs were present throughout the retina, but immunoreactivity for the corresponding proteins was largely restricted to the periphery of the optic cup. MBNL2 immunoreactivity first appeared in their inner segments and remained there.
Title: Developmental regulation of muscleblind-like (MBNL) gene expression in the chicken embryo retina.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: muscleblind-like protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081700.5 → NP_001075169.1 muscleblind-like protein 2 isoform 1

See identical proteins and their annotated locations for NP_001075169.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

JAENSK010000025

UniProtKB/TrEMBL

A0A8V0XK38, A3F962

Related

ENSGALP00010007067.1, ENSGALT00010012503.1

Conserved Domains (1) summary

smart00356
Location:178 → 202

ZnF_C3H1; zinc finger
NM_001163371.4 → NP_001156843.1 muscleblind-like protein 2 isoform 2

See identical proteins and their annotated locations for NP_001156843.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.

Source sequence(s)

JAENSK010000025

UniProtKB/TrEMBL

A0A8V0XSM4, A3F957, F1NLY7

Related

ENSGALP00010007076.1, ENSGALT00010012512.1

Conserved Domains (1) summary

smart00356
Location:178 → 202

ZnF_C3H1; zinc finger
NM_001163372.4 → NP_001156844.1 muscleblind-like protein 2 isoform 3

See identical proteins and their annotated locations for NP_001156844.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks three alternate exons which results in a frameshift compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

JAENSK010000025

UniProtKB/TrEMBL

A0A8V0XSM4, A3F958

Conserved Domains (1) summary

smart00356
Location:178 → 202

ZnF_C3H1; zinc finger
NM_001163373.4 → NP_001156845.1 muscleblind-like protein 2 isoform 4

See identical proteins and their annotated locations for NP_001156845.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The encoded isoform (4) is shorter compared to isoform 1.

Source sequence(s)

JAENSK010000025

UniProtKB/TrEMBL

A0A8V0XSM4, A3F963

Related

ENSGALP00010007079.1, ENSGALT00010012515.1

Conserved Domains (1) summary

smart00356
Location:178 → 202

ZnF_C3H1; zinc finger
NM_001163374.3 → NP_001156846.1 muscleblind-like protein 2 isoform 5

See identical proteins and their annotated locations for NP_001156846.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) uses an alternate in-frame splice site and lacks two alternate exons which results in a frameshift compared to variant 1. The encoded isoform (5) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

JAENSK010000025

UniProtKB/TrEMBL

A0A8V0XSM4, A3F959

Related

ENSGALP00010007056.1, ENSGALT00010012492.1

Conserved Domains (1) summary

smart00356
Location:178 → 202

ZnF_C3H1; zinc finger
NM_001163375.3 → NP_001156847.1 muscleblind-like protein 2 isoform 6

See identical proteins and their annotated locations for NP_001156847.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) lacks three alternate in-frame exons compared to variant 1. The encoded isoform (6) is shorter compared to isoform 1.

Source sequence(s)

JAENSK010000025

UniProtKB/TrEMBL

A3F961

Related

ENSGALP00010007057.1, ENSGALT00010012493.1

Conserved Domains (1) summary

smart00356
Location:17 → 40

ZnF_C3H1; zinc finger
NM_001163376.3 → NP_001156848.1 muscleblind-like protein 2 isoform 7

See identical proteins and their annotated locations for NP_001156848.1

Status: VALIDATED

Description

Transcript Variant: This variant (7) lacks four alternate in-frame exons compared to variant 1. The encoded isoform (7) is shorter compared to isoform 1.

Source sequence(s)

JAENSK010000025

UniProtKB/TrEMBL

A3F960

Conserved Domains (1) summary

smart00356
Location:17 → 40

ZnF_C3H1; zinc finger
NM_001398233.1 → NP_001385162.1 muscleblind-like protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

JAENSK010000025

UniProtKB/TrEMBL

A0A8V0XSM4, A3F958

Conserved Domains (1) summary

smart00356
Location:178 → 202

ZnF_C3H1; zinc finger

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

145340236..145447360 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040699565.2 → XP_040555499.1 muscleblind-like protein 2 isoform X11

Conserved Domains (1) summary

smart00356
Location:83 → 107

ZnF_C3H1; zinc finger
XM_046941306.1 → XP_046797262.1 muscleblind-like protein 2 isoform X10

UniProtKB/TrEMBL

A0A8V0XSM4
XM_040699563.2 → XP_040555497.1 muscleblind-like protein 2 isoform X9

UniProtKB/TrEMBL

A0A8V0XSM4

Conserved Domains (1) summary

smart00356
Location:178 → 202

ZnF_C3H1; zinc finger
XM_040699518.2 → XP_040555452.1 muscleblind-like protein 2 isoform X4

UniProtKB/TrEMBL

A0A8V0XK38

Conserved Domains (1) summary

smart00356
Location:178 → 202

ZnF_C3H1; zinc finger
XM_046941286.1 → XP_046797242.1 muscleblind-like protein 2 isoform X6

UniProtKB/TrEMBL

A0A8V0XK38
XM_015274420.4 → XP_015129906.1 muscleblind-like protein 2 isoform X3

UniProtKB/TrEMBL

A0A8V0XSM4

Conserved Domains (1) summary

smart00356
Location:178 → 202

ZnF_C3H1; zinc finger
XM_040699467.2 → XP_040555401.1 muscleblind-like protein 2 isoform X1

UniProtKB/TrEMBL

A0A8V0XK38

Conserved Domains (1) summary

smart00356
Location:178 → 202

ZnF_C3H1; zinc finger
XM_046941275.1 → XP_046797231.1 muscleblind-like protein 2 isoform X2

UniProtKB/TrEMBL

A0A8V0XK38, A3F962
XM_046941301.1 → XP_046797257.1 muscleblind-like protein 2 isoform X8

UniProtKB/TrEMBL

A0A8V0XSM4, A3F963
XM_046941271.1 → XP_046797227.1 muscleblind-like protein 2 isoform X1

UniProtKB/TrEMBL

A0A8V0XK38
XM_040699538.2 → XP_040555472.1 muscleblind-like protein 2 isoform X7

UniProtKB/TrEMBL

A0A8V0XK38

Conserved Domains (1) summary

smart00356
Location:178 → 202

ZnF_C3H1; zinc finger
XM_025150253.3 → XP_025006021.1 muscleblind-like protein 2 isoform X8

UniProtKB/TrEMBL

A0A8V0XSM4, A3F963

Related

ENSGALP00010007059.1, ENSGALT00010012495.1

Conserved Domains (1) summary

smart00356
Location:178 → 202

ZnF_C3H1; zinc finger
XM_040699514.2 → XP_040555448.1 muscleblind-like protein 2 isoform X4

UniProtKB/TrEMBL

A0A8V0XK38

Conserved Domains (1) summary

smart00356
Location:178 → 202

ZnF_C3H1; zinc finger
XM_040699519.2 → XP_040555453.1 muscleblind-like protein 2 isoform X6

UniProtKB/TrEMBL

A0A8V0XK38

Conserved Domains (1) summary

smart00356
Location:178 → 202

ZnF_C3H1; zinc finger
XM_025150237.3 → XP_025006005.1 muscleblind-like protein 2 isoform X3

UniProtKB/TrEMBL

A0A8V0XSM4

Related

ENSGALP00010007060.1, ENSGALT00010012496.1

Conserved Domains (1) summary

smart00356
Location:178 → 202

ZnF_C3H1; zinc finger
XM_025150239.3 → XP_025006007.1 muscleblind-like protein 2 isoform X5

UniProtKB/TrEMBL

A0A8V0XSM4, A3F957, F1NLY7

Conserved Domains (1) summary

smart00356
Location:178 → 202

ZnF_C3H1; zinc finger
XM_040699473.2 → XP_040555407.1 muscleblind-like protein 2 isoform X1

UniProtKB/TrEMBL

A0A8V0XK38

Related

ENSGALP00010007058.1, ENSGALT00010012494.1

Conserved Domains (1) summary

smart00356
Location:178 → 202

ZnF_C3H1; zinc finger
XM_040699485.2 → XP_040555419.1 muscleblind-like protein 2 isoform X1

UniProtKB/TrEMBL

A0A8V0XK38

Conserved Domains (1) summary

smart00356
Location:178 → 202

ZnF_C3H1; zinc finger
XM_046941278.1 → XP_046797234.1 muscleblind-like protein 2 isoform X3

UniProtKB/TrEMBL

A0A8V0XSM4
XM_040699560.1 → XP_040555494.1 muscleblind-like protein 2 isoform X8

UniProtKB/TrEMBL

A0A8V0XSM4, A3F963

Conserved Domains (1) summary

smart00356
Location:178 → 202

ZnF_C3H1; zinc finger
XM_040699526.2 → XP_040555460.1 muscleblind-like protein 2 isoform X6

UniProtKB/TrEMBL

A0A8V0XK38

Conserved Domains (1) summary

smart00356
Location:178 → 202

ZnF_C3H1; zinc finger
XM_040699478.2 → XP_040555412.1 muscleblind-like protein 2 isoform X1

UniProtKB/TrEMBL

A0A8V0XK38

Conserved Domains (1) summary

smart00356
Location:178 → 202

ZnF_C3H1; zinc finger

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

145332440..145439495 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046908148.1 → XP_046764104.1 muscleblind-like protein 2 isoform X10

UniProtKB/TrEMBL

A0A8V0XSM4
XM_046908147.1 → XP_046764103.1 muscleblind-like protein 2 isoform X9

UniProtKB/TrEMBL

A0A8V0XSM4
XM_046908137.1 → XP_046764093.1 muscleblind-like protein 2 isoform X4

UniProtKB/TrEMBL

A0A8V0XK38

Conserved Domains (1) summary

smart00356
Location:178 → 202

ZnF_C3H1; zinc finger
XM_046908140.1 → XP_046764096.1 muscleblind-like protein 2 isoform X6

UniProtKB/TrEMBL

A0A8V0XK38
XM_046908134.1 → XP_046764090.1 muscleblind-like protein 2 isoform X3

UniProtKB/TrEMBL

A0A8V0XSM4
XM_046908128.1 → XP_046764084.1 muscleblind-like protein 2 isoform X1

UniProtKB/TrEMBL

A0A8V0XK38
XM_046908133.1 → XP_046764089.1 muscleblind-like protein 2 isoform X2

UniProtKB/TrEMBL

A0A8V0XK38, A3F962
XM_046908146.1 → XP_046764102.1 muscleblind-like protein 2 isoform X8

UniProtKB/TrEMBL

A0A8V0XSM4, A3F963
XM_046908131.1 → XP_046764087.1 muscleblind-like protein 2 isoform X1

UniProtKB/TrEMBL

A0A8V0XK38
XM_046908143.1 → XP_046764099.1 muscleblind-like protein 2 isoform X7

UniProtKB/TrEMBL

A0A8V0XK38
XM_046908144.1 → XP_046764100.1 muscleblind-like protein 2 isoform X8

UniProtKB/TrEMBL

A0A8V0XSM4, A3F963
XM_046908139.1 → XP_046764095.1 muscleblind-like protein 2 isoform X4

UniProtKB/TrEMBL

A0A8V0XK38

Conserved Domains (1) summary

smart00356
Location:178 → 202

ZnF_C3H1; zinc finger
XM_046908141.1 → XP_046764097.1 muscleblind-like protein 2 isoform X6

UniProtKB/TrEMBL

A0A8V0XK38
XM_046908135.1 → XP_046764091.1 muscleblind-like protein 2 isoform X3

UniProtKB/TrEMBL

A0A8V0XSM4
XM_046908138.1 → XP_046764094.1 muscleblind-like protein 2 isoform X5

UniProtKB/TrEMBL

A0A8V0XSM4, A3F957, F1NLY7
XM_046908129.1 → XP_046764085.1 muscleblind-like protein 2 isoform X1

UniProtKB/TrEMBL

A0A8V0XK38
XM_046908132.1 → XP_046764088.1 muscleblind-like protein 2 isoform X1

UniProtKB/TrEMBL

A0A8V0XK38
XM_046908136.1 → XP_046764092.1 muscleblind-like protein 2 isoform X3

UniProtKB/TrEMBL

A0A8V0XSM4
XM_046908145.1 → XP_046764101.1 muscleblind-like protein 2 isoform X8

UniProtKB/TrEMBL

A0A8V0XSM4, A3F963
XM_046908142.1 → XP_046764098.1 muscleblind-like protein 2 isoform X6

UniProtKB/TrEMBL

A0A8V0XK38
XM_046908130.1 → XP_046764086.1 muscleblind-like protein 2 isoform X1

UniProtKB/TrEMBL

A0A8V0XK38