CEBPA CCAAT/enhancer binding protein alpha [Gallus gallus (chicken)] - Gene

Summary

Symbol: CEBPAprovided by CGNC
Full Name: CCAAT/enhancer binding protein alphaprovided by CGNC
Primary source: CGNC:66533
See related: Ensembl:ENSGALG00010025039
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: cC/EBP
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	11	NC_052542.1 (9940192..9941462, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	11	NC_052583.1 (10284403..10285673, complement)

Chromosome 11 - NC_052542.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CEBPA promoter is methylated in adipose tissue and may regulate chicken early adipose development
Title: CpG site DNA methylation of the CCAAT/enhancer-binding protein, alpha promoter in chicken lines divergently selected for fatness.
Folate caused a dose-dependent decrease in transcript abundance of peroxisome proliferator-activated receptor gamma (PPARgamma), CCAAT/enhancer-binding protein alpha (C/EBPalpha) gene expression, and the downstream enzyme fatty acid synthase.
Title: Folate supplementation modifies CCAAT/enhancer-binding protein α methylation to mediate differentiation of preadipocytes in chickens.
The results of overexpressing C/EBPalpha and HNF4alpha in cultured cells confirmed that both C/EBPalpha and HNF4alpha contribute significantly to sustaining a high level of CYP2D49 transcription.
Title: Transcriptional regulation of chicken cytochrome P450 2D49 basal expression by CCAAT/enhancer-binding protein α and hepatocyte nuclear factor 4α.
CEBPA involved in lipid metabolism in Beijing-You chickens.
Title: Expression profiles of key transcription factors involved in lipid metabolism in Beijing-You chickens.
The result showed C-EBP alpha was sufficient to trigger the adipogenic program in chicken embryo fibroblasts, as demonstrated by accumulation of cytoplasmic lipid droplets and expression of the adipocyte marker gene.
Title: Transdifferentiation of fibroblasts into adipocyte-like cells by chicken adipogenic transcription factors.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed
involved_in myeloid cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: CCAAT/enhancer-binding protein alpha

Names: CCAAT/enhancer binding protein (C/EBP), alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001031459.2 → NP_001026630.1 CCAAT/enhancer-binding protein alpha

See identical proteins and their annotated locations for NP_001026630.1

Status: VALIDATED

Source sequence(s)

JAENSK010000248

UniProtKB/TrEMBL

Q90582, R4GLL1

Related

ENSGALP00010037816.1, ENSGALT00010061123.1

Conserved Domains (1) summary

cd14711
Location:246 → 306

bZIP_CEBPA; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein alpha (CEBPA): a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052542.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

9940192..9941462 complement

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Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052583.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

10284403..10285673 complement

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GenBank, FASTA, Sequence Viewer (Graphics)