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    MCF2L2 MCF.2 cell line derived transforming sequence-like 2 [ Gallus gallus (chicken) ]

    Gene ID: 424959, updated on 17-Aug-2024

    Summary

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    Symbol
    MCF2L2provided by CGNC
    Full Name
    MCF.2 cell line derived transforming sequence-like 2provided by CGNC
    Primary source
    CGNC:6637
    See related
    Ensembl:ENSGALG00010016355
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human all
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    Genomic context

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    See MCF2L2 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 9 NC_052540.1 (15916355..16071792)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 9 NC_052581.1 (15708822..15863643)

    Chromosome 9 - NC_052540.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA63 Neighboring gene eukaryotic translation initiation factor 4A2 Neighboring gene replication factor C subunit 4 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 Neighboring gene lysosomal associated membrane protein 3 Neighboring gene methylcrotonoyl-CoA carboxylase 1 Neighboring gene defective in cullin neddylation 1 domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    probable guanine nucleotide exchange factor MCF2L2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052540.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      15916355..16071792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025153435.3 → XP_025009203.1  probable guanine nucleotide exchange factor MCF2L2 isoform X7

      UniProtKB/TrEMBL
      A0A8V0Z296
      Conserved Domains (5) summary
      cd11857
      Location:1150 → 1204
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:40 → 178
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:610 → 787
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:309 → 511
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:794 → 925
      PH-like; Pleckstrin homology-like domain

    2. XM_040705707.2 → XP_040561641.1  probable guanine nucleotide exchange factor MCF2L2 isoform X7

      UniProtKB/TrEMBL
      A0A8V0Z296
      Conserved Domains (5) summary
      cd11857
      Location:1150 → 1204
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:40 → 178
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:610 → 787
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:309 → 511
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:794 → 925
      PH-like; Pleckstrin homology-like domain

    3. XM_015291524.4 → XP_015147010.1  probable guanine nucleotide exchange factor MCF2L2 isoform X4

      UniProtKB/TrEMBL
      A0A8V0Z291, A0A8V0Z296
      Related
      ENSGALP00010022736.1, ENSGALT00010039413.1
      Conserved Domains (5) summary
      cd11857
      Location:1171 → 1225
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:61 → 199
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:631 → 808
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:330 → 532
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:815 → 946
      PH-like; Pleckstrin homology-like domain

    4. XM_004943437.5 → XP_004943494.1  probable guanine nucleotide exchange factor MCF2L2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YNZ2, A0A8V0Z296
      Related
      ENSGALP00010022720.1, ENSGALT00010039391.1
      Conserved Domains (6) summary
      cd11857
      Location:1184 → 1238
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:74 → 212
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:644 → 821
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:343 → 545
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00169
      Location:854 → 956
      PH; PH domain
      cl17171
      Location:828 → 959
      PH-like; Pleckstrin homology-like domain

    5. XM_040705705.2 → XP_040561639.1  probable guanine nucleotide exchange factor MCF2L2 isoform X5

      UniProtKB/TrEMBL
      A0A8V0Z296
      Conserved Domains (5) summary
      cd11857
      Location:1155 → 1209
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:74 → 212
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:644 → 821
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:343 → 545
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:828 → 959
      PH-like; Pleckstrin homology-like domain

    6. XM_004943439.5 → XP_004943496.1  probable guanine nucleotide exchange factor MCF2L2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0Z296

    7. XM_004943441.5 → XP_004943498.1  probable guanine nucleotide exchange factor MCF2L2 isoform X6

      UniProtKB/TrEMBL
      A0A8V0YXD9, A0A8V0Z296
      Related
      ENSGALP00010022723.1, ENSGALT00010039395.1
      Conserved Domains (6) summary
      cd11857
      Location:1152 → 1206
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:74 → 212
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:644 → 821
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:343 → 545
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00169
      Location:854 → 956
      PH; PH domain
      cl17171
      Location:828 → 959
      PH-like; Pleckstrin homology-like domain

    8. XM_025153436.3 → XP_025009204.1  probable guanine nucleotide exchange factor MCF2L2 isoform X8

      UniProtKB/TrEMBL
      A0A8V0Z296
      Conserved Domains (5) summary
      cd11857
      Location:1146 → 1200
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:74 → 212
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:644 → 821
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:343 → 545
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:828 → 959
      PH-like; Pleckstrin homology-like domain

    9. XM_004943443.5 → XP_004943500.1  probable guanine nucleotide exchange factor MCF2L2 isoform X10

      UniProtKB/TrEMBL
      A0A8V0YVI0
      Conserved Domains (6) summary
      cd11857
      Location:1122 → 1176
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:74 → 212
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:644 → 821
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:343 → 545
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00169
      Location:854 → 956
      PH; PH domain
      cl17171
      Location:828 → 959
      PH-like; Pleckstrin homology-like domain

    10. XM_025153438.3 → XP_025009206.1  probable guanine nucleotide exchange factor MCF2L2 isoform X11

      UniProtKB/TrEMBL
      A0A8V0YVI0
      Conserved Domains (5) summary
      cd11857
      Location:1093 → 1147
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:74 → 212
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:644 → 821
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:343 → 545
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:828 → 959
      PH-like; Pleckstrin homology-like domain

    11. XM_422768.8 → XP_422768.4  probable guanine nucleotide exchange factor MCF2L2 isoform X12

      UniProtKB/TrEMBL
      A0A8V0YVI0
      Related
      ENSGALP00010022715.1, ENSGALT00010039382.1
      Conserved Domains (6) summary
      cd11857
      Location:1069 → 1123
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:74 → 212
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:644 → 821
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:343 → 545
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00169
      Location:854 → 956
      PH; PH domain
      cl17171
      Location:828 → 959
      PH-like; Pleckstrin homology-like domain

    12. XM_004943438.5 → XP_004943495.1  probable guanine nucleotide exchange factor MCF2L2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0Z296
      Conserved Domains (6) summary
      cd11857
      Location:1182 → 1236
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:74 → 210
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:642 → 819
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:341 → 543
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00169
      Location:852 → 954
      PH; PH domain
      cl17171
      Location:826 → 957
      PH-like; Pleckstrin homology-like domain

    13. XM_025153437.3 → XP_025009205.1  probable guanine nucleotide exchange factor MCF2L2 isoform X9

      UniProtKB/TrEMBL
      A0A8V0Z296
      Conserved Domains (5) summary
      cd11857
      Location:1134 → 1188
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:24 → 162
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:594 → 771
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:293 → 495
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:778 → 909
      PH-like; Pleckstrin homology-like domain

    RNA

    1. XR_006930980.1 RNA Sequence

    2. XR_005862148.2 RNA Sequence

    3. XR_001468035.4 RNA Sequence

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052581.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      15708822..15863643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040678804.2 → XP_040534738.1  probable guanine nucleotide exchange factor MCF2L2 isoform X7

      UniProtKB/TrEMBL
      A0A8V0Z296
      Conserved Domains (5) summary
      cd11857
      Location:1150 → 1204
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:40 → 178
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:610 → 787
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:309 → 511
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:794 → 925
      PH-like; Pleckstrin homology-like domain

    2. XM_040678805.2 → XP_040534739.1  probable guanine nucleotide exchange factor MCF2L2 isoform X7

      UniProtKB/TrEMBL
      A0A8V0Z296
      Conserved Domains (5) summary
      cd11857
      Location:1150 → 1204
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:40 → 178
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:610 → 787
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:309 → 511
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:794 → 925
      PH-like; Pleckstrin homology-like domain

    3. XM_040678800.2 → XP_040534734.1  probable guanine nucleotide exchange factor MCF2L2 isoform X4

      UniProtKB/TrEMBL
      A0A8V0Z291, A0A8V0Z296
      Conserved Domains (5) summary
      cd11857
      Location:1171 → 1225
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:61 → 199
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:631 → 808
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:330 → 532
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:815 → 946
      PH-like; Pleckstrin homology-like domain

    4. XM_040678797.2 → XP_040534731.1  probable guanine nucleotide exchange factor MCF2L2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0Z296
      Conserved Domains (5) summary
      cd11857
      Location:1184 → 1238
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:74 → 212
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:644 → 821
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:343 → 545
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:828 → 959
      PH-like; Pleckstrin homology-like domain

    5. XM_040678801.2 → XP_040534735.1  probable guanine nucleotide exchange factor MCF2L2 isoform X5

      UniProtKB/TrEMBL
      A0A8V0Z296
      Conserved Domains (5) summary
      cd11857
      Location:1155 → 1209
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:74 → 212
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:644 → 821
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:343 → 545
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:828 → 959
      PH-like; Pleckstrin homology-like domain

    6. XM_040678799.2 → XP_040534733.1  probable guanine nucleotide exchange factor MCF2L2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0Z296
      Conserved Domains (5) summary
      cd11857
      Location:1178 → 1232
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:74 → 212
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:644 → 821
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:343 → 545
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:828 → 959
      PH-like; Pleckstrin homology-like domain

    7. XM_040678803.2 → XP_040534737.1  probable guanine nucleotide exchange factor MCF2L2 isoform X6

      UniProtKB/TrEMBL
      A0A8V0Z296
      Conserved Domains (5) summary
      cd11857
      Location:1152 → 1206
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:74 → 212
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:644 → 821
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:343 → 545
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:828 → 959
      PH-like; Pleckstrin homology-like domain

    8. XM_040678806.2 → XP_040534740.1  probable guanine nucleotide exchange factor MCF2L2 isoform X8

      UniProtKB/TrEMBL
      A0A8V0Z296
      Conserved Domains (5) summary
      cd11857
      Location:1146 → 1200
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:74 → 212
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:644 → 821
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:343 → 545
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:828 → 959
      PH-like; Pleckstrin homology-like domain

    9. XM_040678810.2 → XP_040534744.1  probable guanine nucleotide exchange factor MCF2L2 isoform X10

      UniProtKB/TrEMBL
      A0A8V0YVI0
      Conserved Domains (5) summary
      cd11857
      Location:1122 → 1176
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:74 → 212
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:644 → 821
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:343 → 545
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:828 → 959
      PH-like; Pleckstrin homology-like domain

    10. XM_040678811.2 → XP_040534745.1  probable guanine nucleotide exchange factor MCF2L2 isoform X11

      UniProtKB/TrEMBL
      A0A8V0YVI0
      Conserved Domains (5) summary
      cd11857
      Location:1093 → 1147
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:74 → 212
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:644 → 821
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:343 → 545
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:828 → 959
      PH-like; Pleckstrin homology-like domain

    11. XM_040678812.2 → XP_040534746.1  probable guanine nucleotide exchange factor MCF2L2 isoform X12

      UniProtKB/TrEMBL
      A0A8V0YVI0
      Conserved Domains (5) summary
      cd11857
      Location:1069 → 1123
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:74 → 212
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:644 → 821
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:343 → 545
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:828 → 959
      PH-like; Pleckstrin homology-like domain

    12. XM_040678798.2 → XP_040534732.1  probable guanine nucleotide exchange factor MCF2L2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0Z296
      Conserved Domains (5) summary
      cd11857
      Location:1182 → 1236
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:74 → 210
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:642 → 819
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:341 → 543
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:826 → 957
      PH-like; Pleckstrin homology-like domain

    13. XM_040678808.2 → XP_040534742.1  probable guanine nucleotide exchange factor MCF2L2 isoform X9

      UniProtKB/TrEMBL
      A0A8V0Z296
      Conserved Domains (5) summary
      cd11857
      Location:1134 → 1188
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:24 → 162
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:594 → 771
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:293 → 495
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl17171
      Location:778 → 909
      PH-like; Pleckstrin homology-like domain

    RNA

    1. XR_006935670.1 RNA Sequence

    2. XR_005852455.2 RNA Sequence

    3. XR_005852456.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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