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    PPEF2 protein phosphatase with EF-hand domain 2 [ Gallus gallus (chicken) ]

    Gene ID: 422640, updated on 17-Aug-2024

    Summary

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    Symbol
    PPEF2provided by CGNC
    Full Name
    protein phosphatase with EF-hand domain 2provided by CGNC
    Primary source
    CGNC:8756
    See related
    Ensembl:ENSGALG00010004139
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See PPEF2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (49457475..49479397, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (49461608..49483531, complement)

    Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene scavenger receptor class B member 2 Neighboring gene nucleoporin 54 Neighboring gene uncharacterized LOC112532331 Neighboring gene N-acylethanolamine acid amidase Neighboring gene SDA1 domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables Hsp90 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detection of stimulus involved in sensory perception IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase with EF-hands 2
    Names
    protein phosphatase, EF-hand calcium binding domain 2
    XP_015131908.2
    XP_040526773.1
    XP_040526774.1
    XP_040555659.1
    XP_046772998.1
    XP_046796762.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      49457475..49479397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040699725.1 → XP_040555659.1  serine/threonine-protein phosphatase with EF-hands 2 isoform X1

      Conserved Domains (4) summary
      PTZ00184
      Location:589 → 730
      PTZ00184; calmodulin; Provisional
      smart00015
      Location:23 → 42
      IQ; Calmodulin-binding motif
      cd00051
      Location:670 → 735
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd07420
      Location:124 → 550
      MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain

    2. XM_015276422.3 → XP_015131908.2  serine/threonine-protein phosphatase with EF-hands 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0XLK8
      Related
      ENSGALP00010005673.1, ENSGALT00010009660.1
      Conserved Domains (4) summary
      PTZ00184
      Location:561 → 702
      PTZ00184; calmodulin; Provisional
      smart00015
      Location:23 → 42
      IQ; Calmodulin-binding motif
      cd00051
      Location:642 → 707
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd07420
      Location:124 → 522
      MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain

    3. XM_046940806.1 → XP_046796762.1  serine/threonine-protein phosphatase with EF-hands 2 isoform X1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      49461608..49483531 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040670839.1 → XP_040526773.1  serine/threonine-protein phosphatase with EF-hands 2 isoform X1

      Conserved Domains (4) summary
      PTZ00184
      Location:589 → 730
      PTZ00184; calmodulin; Provisional
      smart00015
      Location:23 → 42
      IQ; Calmodulin-binding motif
      cd00051
      Location:670 → 735
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd07420
      Location:124 → 550
      MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain

    2. XM_040670840.2 → XP_040526774.1  serine/threonine-protein phosphatase with EF-hands 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0XLK8
      Conserved Domains (4) summary
      PTZ00184
      Location:561 → 702
      PTZ00184; calmodulin; Provisional
      smart00015
      Location:23 → 42
      IQ; Calmodulin-binding motif
      cd00051
      Location:642 → 707
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd07420
      Location:124 → 522
      MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain

    3. XM_046917042.1 → XP_046772998.1  serine/threonine-protein phosphatase with EF-hands 2 isoform X1

    Nucleotide Protein
    Heading Accession and Version

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    Research Materials