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    TLE1 transducin like enhancer of split 1 [ Gallus gallus (chicken) ]

    Gene ID: 427450, updated on 3-Dec-2024

    Summary

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    Symbol
    TLE1provided by CGNC
    Full Name
    transducin like enhancer of split 1provided by CGNC
    Primary source
    CGNC:9545
    See related
    Ensembl:ENSGALG00010015766
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human all
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    Genomic context

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    See TLE1 in Genome Data Viewer
    Location:
    chromosome: Z
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (39801446..39873047, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (39801446..39873047, complement)

    Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107052312 Neighboring gene uncharacterized LOC121108588 Neighboring gene uncharacterized LOC121108589 Neighboring gene uncharacterized LOC121108590

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Establishment of motor neuron-V3 interneuron progenitor domain boundary in ventral spinal cord requires Groucho-mediated transcriptional corepression. Todd KJ, et al. PLoS One, 2012. PMID 22363571, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TLE is important to promote the formation of the p3 domain and subsequent generation of V3 interneurons.
      Title: Establishment of motor neuron-V3 interneuron progenitor domain boundary in ventral spinal cord requires Groucho-mediated transcriptional corepression.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transducin-like enhancer protein 1
    Names
    transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      39801446..39873047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015280363.4 → XP_015135849.1  transducin-like enhancer protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8V0YT62
      Related
      ENSGALP00010021907.1, ENSGALT00010037973.1
      Conserved Domains (4) summary
      PHA03247
      Location:318 → 475
      PHA03247; large tegument protein UL36; Provisional
      cd00200
      Location:482 → 766
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:486 → 525
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 132
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    2. XM_003643035.6 → XP_003643083.1  transducin-like enhancer protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8V0YT62
      Related
      ENSGALP00010021904.1, ENSGALT00010037964.1
      Conserved Domains (4) summary
      PHA03247
      Location:319 → 476
      PHA03247; large tegument protein UL36; Provisional
      cd00200
      Location:483 → 767
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:487 → 526
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    3. XM_015280362.4 → XP_015135848.1  transducin-like enhancer protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YT62
      Related
      ENSGALP00010021903.1, ENSGALT00010037963.1
      Conserved Domains (4) summary
      COG2319
      Location:485 → 777
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:492 → 776
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 142
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:496 → 535
      7WD40; WD40 repeat [structural motif]

    4. XM_004949181.5 → XP_004949238.1  transducin-like enhancer protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A1D5P5C3, A0A8V0YT62
      Related
      ENSGALP00010021908.1, ENSGALT00010037976.1
      Conserved Domains (4) summary
      PHA03247
      Location:329 → 486
      PHA03247; large tegument protein UL36; Provisional
      cd00200
      Location:493 → 777
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:497 → 536
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    5. XM_015280364.3 → XP_015135850.1  transducin-like enhancer protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A1D5PGR2
      Related
      ENSGALP00010021900.1, ENSGALT00010037955.1
      Conserved Domains (4) summary
      COG2319
      Location:411 → 703
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:418 → 702
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:2 → 68
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:422 → 461
      7WD40; WD40 repeat [structural motif]

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      39801446..39873047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046936734.1 → XP_046792690.1  transducin-like enhancer protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8V0YT62

    2. XM_046936733.1 → XP_046792689.1  transducin-like enhancer protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8V0YT62

    3. XM_046936732.1 → XP_046792688.1  transducin-like enhancer protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YT62

    4. XM_046936731.1 → XP_046792687.1  transducin-like enhancer protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A1D5P5C3, A0A8V0YT62

    5. XM_046936735.1 → XP_046792691.1  transducin-like enhancer protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A1D5PGR2
    Nucleotide Protein
    Heading Accession and Version

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