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    ADAM12 ADAM metallopeptidase domain 12 [ Gallus gallus (chicken) ]

    Gene ID: 425843, updated on 3-Dec-2024

    Summary

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    Symbol
    ADAM12provided by CGNC
    Full Name
    ADAM metallopeptidase domain 12provided by CGNC
    Primary source
    CGNC:9663
    See related
    Ensembl:ENSGALG00010002570
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See ADAM12 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (33362379..33543614, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 6 NC_052578.1 (33247469..33428716, complement)

    Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121113332 Neighboring gene BRCA2 and CDKN1A interacting protein Neighboring gene DEAH-box helicase 32 (putative) Neighboring gene microRNA 6694 Neighboring gene C10orf90 homolog Neighboring gene dedicator of cytokinesis 1 Neighboring gene inhibitory synaptic factor 2A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization and expression analysis of ADAM12 during chicken embryonic development. Lin J, et al. Dev Growth Differ, 2010 Dec. PMID 21158755
    2. Differential expression of five members of the ADAM family in the developing chicken brain. Lin J, et al. Neuroscience, 2008 Nov 19. PMID 18832016
    3. Quantitative and dynamic expression profile of premature and active forms of the regional ADAM proteins during chicken brain development. Markus A, et al. Cell Mol Biol Lett, 2011 Sep. PMID 21786032, Free PMC Article
    4. Differential regional expression of multiple ADAMs during feather bud formation. Lin J, et al. Dev Dyn, 2011 Sep. PMID 21780243
    5. Chicken genomics resource: sequencing and annotation of 35,407 ESTs from single and multiple tissue cDNA libraries and CAP3 assembly of a chicken gene index. Carre W, et al. Physiol Genomics, 2006 May 16. PMID 16554550

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 12
    Names
    ADAM metallopeptidase domain 12 (meltrin alpha)
    disintegrin and metalloprotease 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142850.5 → NP_001136322.2  disintegrin and metalloproteinase domain-containing protein 12 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      JAENSK010000232
      UniProtKB/TrEMBL
      B8XA31, F1NW99
      Related
      ENSGALP00010003681.1, ENSGALT00010005913.1
      Conserved Domains (4) summary
      smart00050
      Location:445 → 519
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:522 → 664
      ACR; ADAM Cysteine-Rich Domain
      PHA03247
      Location:796 → 902
      PHA03247; large tegument protein UL36; Provisional
      cd04269
      Location:226 → 426
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

    2. NM_001270714.5 → NP_001257643.2  disintegrin and metalloproteinase domain-containing protein 12 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks five consecutive exons in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
      Source sequence(s)
      JAENSK010000232
      UniProtKB/TrEMBL
      D6R189
      Related
      ENSGALP00010003685.1, ENSGALT00010005921.1

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      33362379..33543614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040702488.1 → XP_040558422.1  disintegrin and metalloproteinase domain-containing protein 12 isoform X2

      UniProtKB/TrEMBL
      A0A8V0X6E5
      Related
      ENSGALP00010003687.1, ENSGALT00010005924.1
      Conserved Domains (4) summary
      smart00050
      Location:396 → 470
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:473 → 615
      ACR; ADAM Cysteine-Rich Domain
      PHA03247
      Location:747 → 853
      PHA03247; large tegument protein UL36; Provisional
      cd04269
      Location:177 → 377
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

    2. XM_040702484.2 → XP_040558418.1  disintegrin and metalloproteinase domain-containing protein 12 isoform X1

      UniProtKB/TrEMBL
      A0A8V0XDI0, B8XA31, F1NW99
      Related
      ENSGALP00010003669.1, ENSGALT00010005903.1
      Conserved Domains (4) summary
      smart00050
      Location:475 → 549
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:552 → 694
      ACR; ADAM Cysteine-Rich Domain
      PHA03247
      Location:826 → 932
      PHA03247; large tegument protein UL36; Provisional
      cd04269
      Location:256 → 456
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      33247469..33428716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046920393.1 → XP_046776349.1  disintegrin and metalloproteinase domain-containing protein 12 isoform X2

      UniProtKB/TrEMBL
      A0A8V0X6E5

    2. XM_046920392.1 → XP_046776348.1  disintegrin and metalloproteinase domain-containing protein 12 isoform X1

      UniProtKB/TrEMBL
      B8XA31, F1NW99
    Nucleotide Protein
    Heading Accession and Version

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