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    PCSK5 proprotein convertase subtilisin/kexin type 5 [ Gallus gallus (chicken) ]

    Gene ID: 395456, updated on 3-Dec-2024

    Summary

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    Symbol
    PCSK5provided by CGNC
    Full Name
    proprotein convertase subtilisin/kexin type 5provided by CGNC
    Primary source
    CGNC:11283
    See related
    Ensembl:ENSGALG00010015038
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    PC6
    Orthologs
    human mouse all
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    Genomic context

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    See PCSK5 in Genome Data Viewer
    Location:
    chromosome: Z
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (37679894..37941954)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (37679894..37941954)

    Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121108630 Neighboring gene uncharacterized LOC107052308 Neighboring gene uncharacterized LOC121108629 Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC101752170 Neighboring gene riboflavin kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Targeted infection of endothelial cells by avian influenza virus A/FPV/Rostock/34 (H7N1) in chicken embryos. Feldmann A, et al. J Virol, 2000 Sep. PMID 10933711, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptide hormone processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proprotein convertase subtilisin/kexin type 5
    Names
    proprotein convertase PC6
    XP_015135840.2
    XP_040511915.1
    XP_040511917.1
    XP_046791737.1
    XP_046791738.1
    XP_046791739.1
    XP_046791740.1
    XP_424841.5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      37679894..37941954
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015280354.4 → XP_015135840.2  proprotein convertase subtilisin/kexin type 5 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YXI1, A0A8V0YXI6
      Related
      ENSGALP00010021027.1, ENSGALT00010036180.1
      Conserved Domains (5) summary
      pfam03302
      Location:1275 → 1551
      VSP; Giardia variant-specific surface protein
      cd04059
      Location:128 → 422
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:1615 → 1659
      FU; Furin-like repeats
      cd00064
      Location:1570 → 1619
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      cl27557
      Location:509 → 601
      P_proprotein; Proprotein convertase P-domain

    2. XM_424841.8 → XP_424841.5  proprotein convertase subtilisin/kexin type 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YJB0, A0A8V0YSG3
      Related
      ENSGALP00010021019.1, ENSGALT00010036172.1
      Conserved Domains (5) summary
      pfam03302
      Location:674 → 840
      VSP; Giardia variant-specific surface protein
      cd04059
      Location:128 → 422
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:835 → 870
      FU; Furin-like repeats
      cd00064
      Location:637 → 689
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      cl27557
      Location:509 → 601
      P_proprotein; Proprotein convertase P-domain

    3. XM_040655981.2 → XP_040511915.1  proprotein convertase subtilisin/kexin type 5 isoform X3

      Conserved Domains (4) summary
      cd04059
      Location:128 → 422
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:685 → 731
      FU; Furin-like repeats
      cd00064
      Location:637 → 689
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      cl27557
      Location:509 → 601
      P_proprotein; Proprotein convertase P-domain

    4. XM_040655983.2 → XP_040511917.1  proprotein convertase subtilisin/kexin type 5 isoform X4

      Conserved Domains (2) summary
      cd04059
      Location:128 → 422
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam16470
      Location:40 → 116
      S8_pro-domain; Peptidase S8 pro-domain

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      37679894..37941954
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046935781.1 → XP_046791737.1  proprotein convertase subtilisin/kexin type 5 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YXI1, A0A8V0YXI6

    2. XM_046935782.1 → XP_046791738.1  proprotein convertase subtilisin/kexin type 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YJB0, A0A8V0YSG3

    3. XM_046935783.1 → XP_046791739.1  proprotein convertase subtilisin/kexin type 5 isoform X3

    4. XM_046935784.1 → XP_046791740.1  proprotein convertase subtilisin/kexin type 5 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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