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    CREG1 cellular repressor of E1A stimulated genes 1 [ Homo sapiens (human) ]

    Gene ID: 8804, updated on 27-Dec-2024

    Summary

    Official Symbol
    CREG1provided by HGNC
    Official Full Name
    cellular repressor of E1A stimulated genes 1provided by HGNC
    Primary source
    HGNC:HGNC:2351
    See related
    Ensembl:ENSG00000143162 MIM:618055; AllianceGenome:HGNC:2351
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CREG
    Summary
    The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in gall bladder (RPKM 83.3), thyroid (RPKM 78.7) and 25 other tissues See more
    Orthologs
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    Genomic context

    See CREG1 in Genome Data Viewer
    Location:
    1q24.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (167541013..167553762, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (166892470..166905217, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (167510250..167522999, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928512 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1526 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1527 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1529 Neighboring gene CD247 molecule Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:167455187-167455767 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:167472740-167473240 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:167486398-167487597 Neighboring gene uncharacterized LOC107985224 Neighboring gene aldo-keto reductase family 1 member D1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:167509239-167509739 Neighboring gene GATA motif-containing MPRA enhancer 235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1530 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:167533326-167534525 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2042 Neighboring gene ribosomal protein S18 pseudogene 4 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:167586581-167587780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2043 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1531 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:167604143-167604666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:167604667-167605189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2047 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:167625876-167626070 Neighboring gene RCSD domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2049 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:167649515-167649718 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2050 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:167658487-167659686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:167666863-167667545 Neighboring gene Sharpr-MPRA regulatory region 8181 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2051

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in azurophil granule lumen  
    located_in endosome  
    located_in extracellular exosome PubMed 
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    part_of transcription regulator complex  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003851.3 → NP_003842.1  protein CREG1 precursor

      See identical proteins and their annotated locations for NP_003842.1

      Status: REVIEWED

      Source sequence(s)
      AF084523, BC006786
      Consensus CDS
      CCDS1262.1
      UniProtKB/Swiss-Prot
      B2RDD4, O75629, Q8N9A3
      UniProtKB/TrEMBL
      B3KQR3
      Related
      ENSP00000359540.4, ENST00000370509.5
      Conserved Domains (1) summary
      pfam13883
      Location:50 → 216
      Pyrid_oxidase_2; Pyridoxamine 5'-phosphate oxidase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      167541013..167553762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      166892470..166905217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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