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    GPR137B G protein-coupled receptor 137B [ Homo sapiens (human) ]

    Gene ID: 7107, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GPR137Bprovided by HGNC
    Official Full Name
    G protein-coupled receptor 137Bprovided by HGNC
    Primary source
    HGNC:HGNC:11862
    See related
    Ensembl:ENSG00000077585 MIM:604658; AllianceGenome:HGNC:11862
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TM7SF1
    Summary
    Involved in positive regulation of TORC1 signaling; positive regulation of protein localization to lysosome; and regulation of autophagy. Located in lysosomal membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney (RPKM 12.9), brain (RPKM 8.4) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPR137B in Genome Data Viewer
    Location:
    1q42.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (236142539..236208907)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (235544639..235611151)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (236305839..236372207)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak782 silencer Neighboring gene meiotic recombination hotspot NID2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:236162526-236163725 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:236164752-236165460 Neighboring gene nidogen 1 Neighboring gene meiotic recombination hotspot NID1 Neighboring gene NANOG hESC enhancer GRCh37_chr1:236221449-236221986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2812 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1995 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:236244555-236245056 Neighboring gene MS32 minisatellite repeat instability region Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:236259904-236261103 Neighboring gene meiotic recombination hotspot MSTM1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2813 Neighboring gene meiotic recombination hotspot MSTM2 Neighboring gene ACO2 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1997 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:236306063-236306566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:236313713-236314481 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2814 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2815 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1999 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2816 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2817 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2818 Neighboring gene uncharacterized LOC124904561 Neighboring gene endoplasmic reticulum oxidoreductase 1 beta Neighboring gene uncharacterized LOC124904562

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a novel gene (TM7SF1) encoding a putative seven-pass transmembrane protein that is upregulated during kidney development. Spangenberg C, et al. Genomics, 1998 Mar 1. PMID 9521871
    2. Yeast Two-Hybrid Screening for Proteins that Interact with the Extracellular Domain of Amyloid Precursor Protein. Yu Y, et al. Neurosci Bull, 2016 Apr. PMID 26960425, Free PMC Article
    3. Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease. Bommel H, et al. J Cell Biol, 2002 Nov 25. PMID 12446740, Free PMC Article
    4. The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity. Gan L, et al. Nat Cell Biol, 2019 May. PMID 31036939, Free PMC Article
    5. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. McClay JL, et al. Neuropsychopharmacology, 2011 Feb. PMID 21107309, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of bone resorption IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of bone resorption ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of osteoclast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of osteoclast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to lysosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of macrophage activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    integral membrane protein GPR137B
    Names
    transmembrane 7 superfamily member 1 (upregulated in kidney)
    transmembrane 7 superfamily member 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003272.4 → NP_003263.1  integral membrane protein GPR137B

      See identical proteins and their annotated locations for NP_003263.1

      Status: VALIDATED

      Source sequence(s)
      AI634648, BC012100
      Consensus CDS
      CCDS1609.1
      UniProtKB/Swiss-Prot
      O60478, Q53EK7, Q5TAE6, Q6FHI3
      UniProtKB/TrEMBL
      B2R7A7
      Related
      ENSP00000355551.3, ENST00000366592.8
      Conserved Domains (1) summary
      cd21476
      Location:35 → 354
      7tm_GPR137B; Integral membrane protein GPR137B, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      236142539..236208907
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017002209.3 → XP_016857698.1  integral membrane protein GPR137B isoform X1

      UniProtKB/TrEMBL
      B2R7A7
      Conserved Domains (1) summary
      TIGR03022
      Location:80 → 191
      WbaP_sugtrans; Undecaprenyl-phosphate galactose phosphotransferase, WbaP

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      235544639..235611151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338565.1 → XP_054194540.1  integral membrane protein GPR137B isoform X1

      UniProtKB/TrEMBL
      B2R7A7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60478.1 GenPept UniProtKB/Swiss-Prot:O60478

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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