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    MAGEA10 MAGE family member A10 [ Homo sapiens (human) ]

    Gene ID: 4109, updated on 9-Dec-2024

    Summary

    Official Symbol
    MAGEA10provided by HGNC
    Official Full Name
    MAGE family member A10provided by HGNC
    Primary source
    HGNC:HGNC:6797
    See related
    Ensembl:ENSG00000124260 MIM:300343; AllianceGenome:HGNC:6797
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT1.10; MAGE10
    Summary
    This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.[provided by RefSeq, Oct 2011]
    Expression
    Biased expression in placenta (RPKM 4.9) and testis (RPKM 1.2) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MAGEA10 in Genome Data Viewer
    Location:
    Xq28
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (152133310..152138577, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (150399374..150404642, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (151301782..151307049, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA pseudogene 60 Neighboring gene uncharacterized LOC105373369 Neighboring gene MAGEA10-MAGEA5 readthrough Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:151297273-151298472 Neighboring gene MAGE family member A5, pseudogene Neighboring gene Sharpr-MPRA regulatory region 4801 Neighboring gene Sharpr-MPRA regulatory region 4725 Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha3 Neighboring gene RNA, U6 small nuclear 764, pseudogene Neighboring gene microRNA 105-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC10599

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    melanoma-associated antigen 10
    Names
    MAGE-10 antigen
    cancer/testis antigen 1.10
    cancer/testis antigen family 1, member 10
    melanoma antigen family A, 10
    melanoma antigen family A10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011543.3NP_001011543.3  melanoma-associated antigen 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC116666
      Consensus CDS
      CCDS14705.1
      UniProtKB/Swiss-Prot
      P43363
      UniProtKB/TrEMBL
      B2RAE8
      Related
      ENSP00000244096.3, ENST00000244096.7
      Conserved Domains (2) summary
      pfam01454
      Location:141306
      MAGE; MAGE family
      pfam12440
      Location:6116
      MAGE_N; Melanoma associated antigen family N terminal
    2. NM_001251828.2NP_001238757.2  melanoma-associated antigen 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC116666
      Consensus CDS
      CCDS14705.1
      UniProtKB/Swiss-Prot
      P43363
      UniProtKB/TrEMBL
      B2RAE8
      Conserved Domains (2) summary
      pfam01454
      Location:141306
      MAGE; MAGE family
      pfam12440
      Location:6116
      MAGE_N; Melanoma associated antigen family N terminal
    3. NM_021048.5NP_066386.3  melanoma-associated antigen 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC116666
      Consensus CDS
      CCDS14705.1
      UniProtKB/Swiss-Prot
      P43363
      UniProtKB/TrEMBL
      B2RAE8
      Related
      ENSP00000359347.4, ENST00000370323.9
      Conserved Domains (2) summary
      pfam01454
      Location:141306
      MAGE; MAGE family
      pfam12440
      Location:6116
      MAGE_N; Melanoma associated antigen family N terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      152133310..152138577 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      150399374..150404642 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)