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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_023225.1 RefSeqGene
- Range
-
5116..19528
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001130410.2 → NP_001123882.1 3-ketoacyl-CoA thiolase, peroxisomal isoform b
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
- Source sequence(s)
-
BC011977, BC014474, DC312566
- Consensus CDS
-
CCDS46794.1
- UniProtKB/TrEMBL
-
A0A140VJX0
- Related
- ENSP00000301810.7, ENST00000301810.11
- Conserved Domains (1) summary
-
- cl27751
Location:1 → 327
- Thiolase_N; Thiolase, N-terminal domain
-
NM_001607.4 → NP_001598.1 3-ketoacyl-CoA thiolase, peroxisomal isoform a
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
- Source sequence(s)
-
BC011977, DC312566
- Consensus CDS
-
CCDS2673.1
- UniProtKB/Swiss-Prot
- G5E935, P09110, Q96CA6
- UniProtKB/TrEMBL
- A0A024R2M6, A0A384NL32, C9JDE9
- Related
- ENSP00000333664.8, ENST00000333167.13
- Conserved Domains (1) summary
-
- cl27751
Location:1 → 420
- Thiolase_N; Thiolase, N-terminal domain
RNA
-
NR_024024.2 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) lacks an alternate exon in the coding region, compared to variant 1, which results in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated decay (NMD).
- Source sequence(s)
-
AF035295, BC011977, BC039837, DC312566
- Related
-
ENST00000411549.5
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000003.12 Reference GRCh38.p14 Primary Assembly
- Range
-
38122715..38137127 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_006713122.1 → XP_006713185.1 3-ketoacyl-CoA thiolase, peroxisomal isoform X1
- UniProtKB/TrEMBL
-
C9JDE9
- Conserved Domains (2) summary
-
- PLN02287
Location:1 → 360
- PLN02287; 3-ketoacyl-CoA thiolase
- cd00751
Location:39 → 361
- thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
-
XM_047448057.1 → XP_047304013.1 3-ketoacyl-CoA thiolase, peroxisomal isoform X3
- UniProtKB/TrEMBL
-
Q8NCW8
-
XM_011533650.3 → XP_011531952.1 3-ketoacyl-CoA thiolase, peroxisomal isoform X2
- UniProtKB/TrEMBL
-
Q8NCW8
- Conserved Domains (1) summary
-
- cd00751
Location:1 → 276
- thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
Alternate T2T-CHM13v2.0
Genomic
-
NC_060927.1 Alternate T2T-CHM13v2.0
- Range
-
38128384..38142796 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054346392.1 → XP_054202367.1 3-ketoacyl-CoA thiolase, peroxisomal isoform X1
- UniProtKB/TrEMBL
-
C9JDE9
-
XM_054346394.1 → XP_054202369.1 3-ketoacyl-CoA thiolase, peroxisomal isoform X3
- UniProtKB/TrEMBL
-
Q8NCW8
-
XM_054346393.1 → XP_054202368.1 3-ketoacyl-CoA thiolase, peroxisomal isoform X2
- UniProtKB/TrEMBL
-
Q8NCW8