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    PIGZ phosphatidylinositol glycan anchor biosynthesis class Z [ Homo sapiens (human) ]

    Gene ID: 80235, updated on 10-Dec-2024

    Summary

    Official Symbol
    PIGZprovided by HGNC
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis class Zprovided by HGNC
    Primary source
    HGNC:HGNC:30596
    See related
    Ensembl:ENSG00000119227 MIM:611671; AllianceGenome:HGNC:30596
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SMP3; PIG-Z; GPI-MT-IV
    Summary
    The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. This gene encodes a protein that is localized to the endoplasmic reticulum, and is involved in GPI anchor biosynthesis. As shown for the yeast homolog, which is a member of a family of dolichol-phosphate-mannose (Dol-P-Man)-dependent mannosyltransferases, this protein can also add a side-branching fourth mannose to GPI precursors during the assembly of GPI anchors. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in colon (RPKM 5.3), brain (RPKM 1.9) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PIGZ in Genome Data Viewer
    Location:
    3q29
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (196946356..196968833, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (199672412..199695067, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (196673227..196695704, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene nuclear cap binding protein subunit 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:196668731-196669404 Neighboring gene NCBP2 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:196669405-196670078 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:196670753-196671426 Neighboring gene NCBP2 antisense 2 (head to head) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:196674955-196675702 Neighboring gene Sharpr-MPRA regulatory region 11589 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:196695281-196695816 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:196695817-196696352 Neighboring gene collagen alpha-1(I) chain-like Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:196696353-196696888 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21106 Neighboring gene 40S ribosomal protein SA-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ12768, MGC52163

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in endoplasmic reticulum PubMed 
    is_active_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  

    General protein information

    Preferred Names
    GPI mannosyltransferase 4
    Names
    GPI mannosyltransferase IV
    SMP3 mannosyltransferase
    dol-P-Man dependent GPI mannosyltransferase
    phosphatidylinositol glycan, class Z
    phosphatidylinositol-glycan biosynthesis class Z protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025163.4 → NP_079439.2  GPI mannosyltransferase 4

      See identical proteins and their annotated locations for NP_079439.2

      Status: REVIEWED

      Source sequence(s)
      AK022830, AK296867, BC018804, BG760692, BX493581
      Consensus CDS
      CCDS3324.1
      UniProtKB/Swiss-Prot
      Q86VD9, Q9H9G6
      Related
      ENSP00000413405.1, ENST00000412723.6
      Conserved Domains (1) summary
      cl21590
      Location:44 → 391
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      196946356..196968833 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011513192.3 → XP_011511494.1  GPI mannosyltransferase 4 isoform X2

      See identical proteins and their annotated locations for XP_011511494.1

      Conserved Domains (1) summary
      cl21590
      Location:83 → 430
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
    2. XM_047448993.1 → XP_047304949.1  GPI mannosyltransferase 4 isoform X2

    3. XM_024453767.2 → XP_024309535.1  GPI mannosyltransferase 4 isoform X1

      Conserved Domains (1) summary
      cl21590
      Location:109 → 456
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
    4. XM_024453766.2 → XP_024309534.1  GPI mannosyltransferase 4 isoform X1

      Conserved Domains (1) summary
      cl21590
      Location:109 → 456
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
    5. XM_017007241.2 → XP_016862730.1  GPI mannosyltransferase 4 isoform X1

      Conserved Domains (1) summary
      cl21590
      Location:109 → 456
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
    6. XM_017007243.2 → XP_016862732.1  GPI mannosyltransferase 4 isoform X3

      UniProtKB/TrEMBL
      B4DL68
      Conserved Domains (1) summary
      cl21590
      Location:5 → 241
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      199672412..199695067 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347966.1 → XP_054203941.1  GPI mannosyltransferase 4 isoform X1

    2. XM_054347970.1 → XP_054203945.1  GPI mannosyltransferase 4 isoform X2

    3. XM_054347969.1 → XP_054203944.1  GPI mannosyltransferase 4 isoform X2

    4. XM_054347968.1 → XP_054203943.1  GPI mannosyltransferase 4 isoform X1

    5. XM_054347967.1 → XP_054203942.1  GPI mannosyltransferase 4 isoform X1

    6. XM_054347965.1 → XP_054203940.1  GPI mannosyltransferase 4 isoform X1

    7. XM_054347971.1 → XP_054203946.1  GPI mannosyltransferase 4 isoform X3

      UniProtKB/TrEMBL
      B4DL68
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