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    YPEL3 yippee like 3 [ Homo sapiens (human) ]

    Gene ID: 83719, updated on 10-Dec-2024

    Summary

    Official Symbol
    YPEL3provided by HGNC
    Official Full Name
    yippee like 3provided by HGNC
    Primary source
    HGNC:HGNC:18327
    See related
    Ensembl:ENSG00000090238 MIM:609724; AllianceGenome:HGNC:18327
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable metal ion binding activity. Involved in positive regulation of cellular senescence. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in spleen (RPKM 26.2), brain (RPKM 22.3) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See YPEL3 in Genome Data Viewer
    Location:
    16p11.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (30092314..30096213, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (30374954..30378853, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30103635..30107534, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10689 Neighboring gene protein phosphatase 4 catalytic subunit Neighboring gene ReSE screen-validated silencer GRCh37_chr16:30096821-30096985 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30101709-30102582 Neighboring gene T-box transcription factor 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7352 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10690 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30107354-30107960 Neighboring gene YPEL3 divergent transcript Neighboring gene glycerophosphodiester phosphodiesterase domain containing 3 Neighboring gene Sharpr-MPRA regulatory region 9068 Neighboring gene mitogen-activated protein kinase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7356

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (34 hits/1265 screens)

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC10500

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding  
    Component Evidence Code Pubs
    located_in nucleolus  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145524.2NP_001138996.1  protein yippee-like 3 isoform 2

      See identical proteins and their annotated locations for NP_001138996.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents alternate splicing in the first exon (of variant 1) resulting in predicted use of a downstream translation start site and a shorter protein (isoform 2).
      Source sequence(s)
      AB098737, AC012645
      Consensus CDS
      CCDS45459.1
      UniProtKB/Swiss-Prot
      P61236, Q65Z99, Q86VK6, Q9BSJ4, Q9CQB6
      UniProtKB/TrEMBL
      H3BME7
      Related
      ENSP00000381818.4, ENST00000398838.8
      Conserved Domains (1) summary
      cl13152
      Location:21110
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains
    2. NM_031477.5NP_113665.3  protein yippee-like 3 isoform 1

      See identical proteins and their annotated locations for NP_113665.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents a longer transcript and longer protein isoform (1).
      Source sequence(s)
      AC012645, BC050664
      Consensus CDS
      CCDS42147.1
      UniProtKB/TrEMBL
      A0A0B4J290
      Related
      ENSP00000381821.1, ENST00000398841.6
      Conserved Domains (1) summary
      cl13152
      Location:59148
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      30092314..30096213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      30374954..30378853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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