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    YKE2 tubulin-binding prefolding complex subunit YKE2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850897, updated on 9-Dec-2024

    Summary

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    Official Symbol
    YKE2
    Official Full Name
    tubulin-binding prefolding complex subunit YKE2
    Primary source
    SGD:S000004190
    Locus tag
    YLR200W
    See related
    AllianceGenome:SGD:S000004190; FungiDB:YLR200W; VEuPathDB:YLR200W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GIM1; PFD6
    Summary
    Enables tubulin binding activity. Involved in positive regulation of transcription elongation by RNA polymerase II; protein folding; and tubulin complex assembly. Located in cytoplasm. Part of prefoldin complex. Orthologous to human PFDN6 (prefoldin subunit 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See YKE2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (549012..549356)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene snoRNP complex protein NOP56 Neighboring gene Pba1p Neighboring gene ubiquinone biosynthesis protein COQ9 Neighboring gene Mss51p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Budding yeast SSD1-V regulates transcript levels of many longevity genes and extends chronological life span in purified quiescent cells. Li L, et al. Mol Biol Cell, 2009 Sep. PMID 19570907, Free PMC Article
    2. Genome-Wide Screens in Saccharomyces cerevisiae Highlight a Role for Cardiolipin in Biogenesis of Mitochondrial Outer Membrane Multispan Proteins. Sauerwald J, et al. Mol Cell Biol, 2015 Sep. PMID 26149385, Free PMC Article
    3. Prefoldin Promotes Proteasomal Degradation of Cytosolic Proteins with Missense Mutations by Maintaining Substrate Solubility. Comyn SA, et al. PLoS Genet, 2016 Jul. PMID 27448207, Free PMC Article
    4. Compartmentation of protein folding in vivo: sequestration of non-native polypeptide by the chaperonin-GimC system. Siegers K, et al. EMBO J, 1999 Jan 4. PMID 9878052, Free PMC Article
    5. The yeast ubiquitin protease, Ubp3p, promotes protein stability. Brew CT, et al. Genetics, 2002 Nov. PMID 12454057, Free PMC Article

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription elongation by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tubulin complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of prefoldin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of prefoldin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of prefoldin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tubulin-binding prefolding complex subunit YKE2
    NP_013301.1
    • Subunit of the heterohexameric Gim/prefoldin protein complex; involved in the folding of alpha-tubulin, beta-tubulin, and actin; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      549012..549356
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182087.1 → NP_013301.1  TPA: tubulin-binding prefolding complex subunit YKE2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013301.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYK2, P52553
      UniProtKB/TrEMBL
      A7A189, B3RH90, C7GIT1, G2WJ31, N1NYD5
      Conserved Domains (1) summary
      cd00632
      Location:1 → 105
      Prefoldin_beta; Prefoldin beta; Prefoldin is a hexameric molecular chaperone complex, composed of two evolutionarily related subunits (alpha and beta), which are found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52553.1

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