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    MRS4 Fe(2+) transporter [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853926, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MRS4
    Official Full Name
    Fe(2+) transporter
    Primary source
    SGD:S000001760
    Locus tag
    YKR052C
    See related
    AllianceGenome:SGD:S000001760; FungiDB:YKR052C; VEuPathDB:YKR052C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables iron ion transmembrane transporter activity. Involved in iron import into the mitochondrion. Located in mitochondrial inner membrane. Orthologous to human SLC25A28 (solute carrier family 25 member 28) and SLC25A37 (solute carrier family 25 member 37). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MRS4 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (532550..533464, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Trk2p Neighboring gene Hfl1p Neighboring gene sphinganine kinase YSR3 Neighboring gene dynein heavy chain

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MRS3 and MRS4, two suppressors of mtRNA splicing defects in yeast, are new members of the mitochondrial carrier family. Wiesenberger G, et al. J Mol Biol, 1991 Jan 5. PMID 1703236
    2. Three conserved histidine residues contribute to mitochondrial iron transport through mitoferrins. Brazzolotto X, et al. Biochem J, 2014 May 15. PMID 24624902
    3. The yeast mitochondrial carrier proteins Mrs3p/Mrs4p mediate iron transport across the inner mitochondrial membrane. Froschauer EM, et al. Biochim Biophys Acta, 2009 May. PMID 19285482
    4. Recovery of mrs3Δmrs4Δ Saccharomyces cerevisiae Cells under Iron-Sufficient Conditions and the Role of Fe(580). Moore MJ, et al. Biochemistry, 2018 Feb 6. PMID 29228768, Free PMC Article
    5. A specific role of the yeast mitochondrial carriers MRS3/4p in mitochondrial iron acquisition under iron-limiting conditions. Mühlenhoff U, et al. J Biol Chem, 2003 Oct 17. PMID 12902335

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Three highly conserved histidine residues are important for Mrs3p function and mitochondrial iron transport when Mrs (mitochondrial RNA splicing)3p and Mrs4p are inserted into liposomes.
      Title: Three conserved histidine residues contribute to mitochondrial iron transport through mitoferrins.
    2. Inner mitochondrial membrane vesicles (SMPs) from the double deletion strain mrs3/4Delta failed to show a rapid Fe(2+) uptake, while SMPs from cells overproducing Mrs3/4p exhibited increased Fe(2+) uptake rates.
      Title: The yeast mitochondrial carrier proteins Mrs3p/Mrs4p mediate iron transport across the inner mitochondrial membrane.
    3. defective heme formation in mutants, with a markedly more severe defect in the DeltaDeltaDelta than in the individual Deltamrs3/4 or Deltayfh1 mutants
      Title: Frataxin and mitochondrial carrier proteins, Mrs3p and Mrs4p, cooperate in providing iron for heme synthesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ferrous iron transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in iron import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron import into the mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in iron import into the mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Fe(2+) transporter
    NP_012978.1
    • Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      532550..533464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179842.1 → NP_012978.1  TPA: Fe(2+) transporter [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012978.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXB3, P23500
      UniProtKB/TrEMBL
      A7A012, B3LRC9, B5VMJ9, C7GNL3, C8ZCL6, G2WI80, N1P0Y0
      Conserved Domains (2) summary
      PTZ00168
      Location:27 → 252
      PTZ00168; mitochondrial carrier protein; Provisional
      pfam00153
      Location:205 → 304
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23500.1

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