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    STE18 Ste18p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853548, updated on 9-Dec-2024

    Summary

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    Official Symbol
    STE18
    Official Full Name
    Ste18p
    Primary source
    SGD:S000003846
    Locus tag
    YJR086W
    See related
    AllianceGenome:SGD:S000003846; FungiDB:YJR086W; VEuPathDB:YJR086W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables G-protein beta-subunit binding activity. Involved in pheromone-dependent signal transduction involved in conjugation with cellular fusion. Located in cytoplasm and plasma membrane. Part of Cdc24p-Far1p-Gbetagamma complex; G-protein beta/gamma-subunit complex; and heterotrimeric G-protein complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See STE18 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (586068..586400)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Tmh11p Neighboring gene Emc2p Neighboring gene survivin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Common modifications of trimeric G proteins and ras protein: involvement of polyisoprenylation. Finegold AA, et al. Science, 1990 Jul 13. PMID 1695391
    2. Biochemical and genetic analysis of dominant-negative mutations affecting a yeast G-protein gamma subunit. Grishin AV, et al. Mol Cell Biol, 1994 Jul. PMID 8007961, Free PMC Article
    3. The C-terminal tail preceding the CAAX box of a yeast G protein gamma subunit is dispensable for receptor-mediated G protein activation in vivo. Chinault SL, et al. J Biol Chem, 2003 Jun 6. PMID 12665529
    4. Dual lipid modification motifs in G(alpha) and G(gamma) subunits are required for full activity of the pheromone response pathway in Saccharomyces cerevisiae. Manahan CL, et al. Mol Biol Cell, 2000 Mar. PMID 10712512, Free PMC Article
    5. Mutagenesis of Ste18, a putative G gamma subunit in the Saccharomyces cerevisiae pheromone response pathway. Whiteway M, et al. Biochem Cell Biol, 1992 Oct-Nov. PMID 1297344

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aggregation and Prion-Inducing Properties of the G-Protein Gamma Subunit Ste18 are Regulated by Membrane Association.
      Title: Aggregation and Prion-Inducing Properties of the G-Protein Gamma Subunit Ste18 are Regulated by Membrane Association.
    2. phosphorylation of the yeast Ggamma subunit (Ste18), together with Fus3 docking on Ste5, controls the rate and stability of Ste5/plasma membrane association.
      Title: Negative Feedback Phosphorylation of Gγ Subunit Ste18 and the Ste5 Scaffold Synergistically Regulates MAPK Activation in Yeast.
    3. Data show that the pheromone-responsive G protein subunits beta/gamma (Gbetagamma; STE4/STE18) dimer promotes the polarization of the pheromone receptor by interacting with casein kinases 1 or 2 (Yck1/2) and locally inhibiting receptor phosphorylation.
      Title: Gβ promotes pheromone receptor polarization and yeast chemotropism by inhibiting receptor phosphorylation.
    4. These results indicate that chemoattractant-induced cell polarization requires continuous receptor-Galphabetagamma communication but not modulation of MAP kinase signaling.
      Title: Distinct roles for two Galpha-Gbeta interfaces in cell polarity control by a yeast heterotrimeric G protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G-protein beta-subunit binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to pheromone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Cdc24p-Far1p-Gbetagamma complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of G-protein beta/gamma-subunit complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of G-protein beta/gamma-subunit complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    part_of G-protein beta/gamma-subunit complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cell periphery HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of heterotrimeric G-protein complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ste18p
    NP_012619.1
    • G protein gamma subunit; forms dimer with Ste4p to activate mating signaling pathway, heterotrimer with Gpa1p, Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling; N-terminal phosphorylation of Ste18p functions synergistically with Fus3p docking site on Ste5p to restrict Ste5p plasma membrane recruitment and signaling; combinatorial phosphorylation at S3 and S7, by pheromone and pH stress, modulates Ste18p structure, Fus3p activation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      586068..586400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181743.1 → NP_012619.1  TPA: Ste18p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012619.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWQ5, P18852
      UniProtKB/TrEMBL
      A6ZQ42, B3LQH1, C7GMC0, C8ZBN2, G2WH89, N1P161
      Conserved Domains (1) summary
      pfam00631
      Location:29 → 91
      G-gamma; GGL domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18852.1

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