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    HOC1 alpha-1,6-mannosyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853538, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HOC1
    Official Full Name
    alpha-1,6-mannosyltransferase
    Primary source
    SGD:S000003836
    Locus tag
    YJR075W
    See related
    AllianceGenome:SGD:S000003836; FungiDB:YJR075W; VEuPathDB:YJR075W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to alpha-1,6-mannosyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Part of mannan polymerase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HOC1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (573981..575171)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Neighboring gene Ran GTPase-binding protein MOG1 Neighboring gene septin CDC11 Neighboring gene Mir1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae HOC1, a suppressor of pkc1, encodes a putative glycosyltransferase. Neiman AM, et al. Genetics, 1997 Mar. PMID 9055074, Free PMC Article
    2. Novel membrane protein complexes for protein glycosylation in the yeast Golgi apparatus. Hashimoto H, et al. Biochem Biophys Res Commun, 1997 Dec 29. PMID 9434768
    3. Multi-protein complexes in the cis Golgi of Saccharomyces cerevisiae with alpha-1,6-mannosyltransferase activity. Jungmann J, et al. EMBO J, 1998 Jan 15. PMID 9430634, Free PMC Article
    4. Interaction among the subunits of Golgi membrane mannosyltransferase complexes of the yeast Saccharomyces cerevisiae. Kojima H, et al. Biosci Biotechnol Biochem, 1999 Nov. PMID 10635561
    5. The Saccharomyces cerevisiae protein Mnn10p/Bed1p is a subunit of a Golgi mannosyltransferase complex. Jungmann J, et al. J Biol Chem, 1999 Mar 5. PMID 10037752

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to alpha-1,6-mannosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-1,6-mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate derivative metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell wall mannoprotein biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in substituted mannan metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mannan polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mannan polymerase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mannan polymerase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,6-mannosyltransferase
    NP_012609.3
    • Alpha-1,6-mannosyltransferase; involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      573981..575171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181733.3 → NP_012609.3  TPA: alpha-1,6-mannosyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012609.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWP5, E9P8X6, P47124
      UniProtKB/TrEMBL
      A6ZQ33, B3LQG1, C7GMC9, C8ZBM2, G2WH79, N1P154
      Conserved Domains (1) summary
      COG3774
      Location:7 → 396
      OCH1; Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47124.3

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