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    ATP12 ATP synthase complex assembly protein ATP12 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853259, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ATP12
    Official Full Name
    ATP synthase complex assembly protein ATP12
    Primary source
    SGD:S000003716
    Locus tag
    YJL180C
    See related
    AllianceGenome:SGD:S000003716; FungiDB:YJL180C; VEuPathDB:YJL180C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein domain specific binding activity. Involved in mitochondrial proton-transporting ATP synthase complex assembly. Located in mitochondrion. Used to study mitochondrial complex V (ATP synthase) deficiency nuclear type 1. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 1. Orthologous to human ATPAF2 (ATP synthase mitochondrial F1 complex assembly factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ATP12 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (87583..88560, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene alpha-1,6-mannosyltransferase Neighboring gene Rbh1p Neighboring gene prefolding complex chaperone subunit Neighboring gene Atg27p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutational studies with Atp12p, a protein required for assembly of the mitochondrial F1-ATPase in yeast. Identification of domains important for Atp12p function and oligomerization. Wang ZG, et al. J Biol Chem, 1998 Jan 30. PMID 9446613
    2. Respiratory chain complex V deficiency due to a mutation in the assembly gene ATP12. De Meirleir L, et al. J Med Genet, 2004 Feb. PMID 14757859, Free PMC Article
    3. Identification of a nuclear gene (FMC1) required for the assembly/stability of yeast mitochondrial F(1)-ATPase in heat stress conditions. Lefebvre-Legendre L, et al. J Biol Chem, 2001 Mar 2. PMID 11096112
    4. Defining the pathogenesis of the human Atp12p W94R mutation using a Saccharomyces cerevisiae yeast model. Meulemans A, et al. J Biol Chem, 2010 Feb 5. PMID 19933271, Free PMC Article
    5. Atp11p and Atp12p are chaperones for F(1)-ATPase biogenesis in mitochondria. Ackerman SH. Biochim Biophys Acta, 2002 Sep 10. PMID 12206899

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that wild type human Atp12p rescues the respiratory defect of a yeast ATP12 deletion mutant (Deltaatp12).
      Title: Defining the pathogenesis of the human Atp12p W94R mutation using a Saccharomyces cerevisiae yeast model.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial proton-transporting ATP synthase complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial proton-transporting ATP synthase complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial proton-transporting ATP synthase complex assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in proton-transporting ATP synthase complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase complex assembly protein ATP12
    NP_012355.1
    • Assembly factor for F1 sector of mitochondrial F1F0 ATP synthase; conserved protein; required for assembly of alpha and beta subunits into F1 sector of mitochondrial F1F0 ATP synthase; human homolog ATPAF2 can complement yeast atp12 mutant; mutation of human homolog reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      87583..88560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181613.1 → NP_012355.1  TPA: ATP synthase complex assembly protein ATP12 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012355.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW09, P22135
      UniProtKB/TrEMBL
      A6ZQF4, B3LPU5, B5VL10, C7GS06, C8ZB39, G2WGJ5, N1P0D8
      Conserved Domains (1) summary
      COG5387
      Location:18 → 325
      Atp12; Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22135.2

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