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    CIR1 Cir1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853121, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CIR1
    Official Full Name
    Cir1p
    Primary source
    SGD:S000003439
    Locus tag
    YGR207C
    See related
    AllianceGenome:SGD:S000003439; FungiDB:YGR207C; VEuPathDB:YGR207C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable electron transfer activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase. Located in mitochondrion. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFB (electron transfer flavoprotein subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CIR1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (910843..911628, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene putative ATP-dependent kinase Neighboring gene ubiquitin-binding ESCRT-I subunit protein MVB12 Neighboring gene phosphoserine phosphatase Neighboring gene thioredoxin TRX2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Saccharomyces cerevisiae Genes, AIM45, YGR207c/CIR1 and YOR356w/CIR2, Are Involved in Cellular Redox State Under Stress Conditions. Lopes J, et al. Open Microbiol J, 2010 Aug 17. PMID 21253464, Free PMC Article
    2. Sequencing of a 17.6 kb segment on the right arm of yeast chromosome VII reveals 12 ORFs, including CCT, ADE3 and TR-I genes, homologues of the yeast PMT and EF1G genes, of the human and bacterial electron-transferring flavoproteins (beta-chain) and of the Escherichia coli phosphoserine phosphohydrolase, and five new ORFs. Guerreiro P, et al. Yeast, 1996 Mar 15. PMID 8904340
    3. Frataxin interacts functionally with mitochondrial electron transport chain proteins. González-Cabo P, et al. Hum Mol Genet, 2005 Aug 1. PMID 15961414
    4. Identification of gold nanoparticle-resistant mutants of Saccharomyces cerevisiae suggests a role for respiratory metabolism in mediating toxicity. Smith MR, et al. Appl Environ Microbiol, 2013 Jan. PMID 23144132, Free PMC Article
    5. Comprehensive characterization of the Hsp70 interactome reveals novel client proteins and interactions mediated by posttranslational modifications. Nitika, et al. PLoS Biol, 2022 Oct. PMID 36269765, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables electron transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cir1p
    NP_011723.1
    • Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      910843..911628 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181336.1 → NP_011723.1  TPA: Cir1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011723.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUZ0, P42940
      UniProtKB/TrEMBL
      A6ZUL8, B3LI29, B5VJE8, C7GRP0, C8Z9A0, G2WET6, N1P9Y3
      Conserved Domains (1) summary
      COG2086
      Location:7 → 261
      FixA; Electron transfer flavoprotein, alpha and beta subunits [Energy production and conversion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42940.1

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