PSD2 phosphatidylserine decarboxylase 2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PSD2
Official Full Name: phosphatidylserine decarboxylase 2
Primary source: SGD:S000003402
Locus tag: YGR170W
See related: AllianceGenome:SGD:S000003402; FungiDB:YGR170W; VEuPathDB:YGR170W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables phosphatidylserine decarboxylase activity. Involved in phosphatidylcholine biosynthetic process. Located in endosome. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PSD2 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (837142..840558)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Noncanonical regulation of phosphatidylserine metabolism by a Sec14-like protein and a lipid kinase.
Title: Noncanonical regulation of phosphatidylserine metabolism by a Sec14-like protein and a lipid kinase.
results showed that VID22 is required for transcriptional activation of the PSD2 gene.
Title: VID22 is required for transcriptional activation of the PSD2 gene in the yeast Saccharomyces cerevisiae.
model predicts that this process involves an acceptor membrane complex containing the C2 domains of Psd2p, PstB2p, and Pbi1p that ligate to Scs2p and phosphatidic acid present in the donor membrane
Title: An assembly of proteins and lipid domains regulates transport of phosphatidylserine to phosphatidylserine decarboxylase 2 in Saccharomyces cerevisiae.
Data demonstrate that loss of Psd2 causes cells to acquire sensitivity to cadmium even though Psd1 remains intact.
Title: Compartment-specific synthesis of phosphatidylethanolamine is required for normal heavy metal resistance.
mitochondrial biosynthesis of phosphatidylethanolamine is essential for the viability of yeast mutants lacking cardiolipin
Title: Synthetic lethal interaction of the mitochondrial phosphatidylethanolamine and cardiolipin biosynthetic pathways in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylserine decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylserine decarboxylase activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in glycerophospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylethanolamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in protein autoprocessing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi stack	IEA Inferred from Electronic Annotation more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphatidylserine decarboxylase 2

NP_011686.1

EC 4.1.1.65

Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes; converts phosphatidylserine to phosphatidylethanolamine; controls vacuolar membrane phospholipid content by regulating phospholipids in compartments that will eventually give rise to the vacuole; loss of Psd2p causes a specific reduction in vacuolar membrane PE levels while total PE levels are not significantly affected

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

837142..840558

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181299.1 → NP_011686.1 TPA: phosphatidylserine decarboxylase 2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011686.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUV4, P53037

UniProtKB/TrEMBL

B3LI60, C7GQ77, N1P3V1

Conserved Domains (3) summary

cd00030
Location:19 → 86

C2; C2 domain

PLN02964
Location:523 → 1079

PLN02964; phosphatidylserine decarboxylase

NF033845
Location:276 → 453

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB