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    TRM1 tRNA (guanine26-N2)-dimethyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851698, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TRM1
    Official Full Name
    tRNA (guanine26-N2)-dimethyltransferase
    Primary source
    SGD:S000002527
    Locus tag
    YDR120C
    See related
    AllianceGenome:SGD:S000002527; FungiDB:YDR120C; VEuPathDB:YDR120C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables tRNA (guanine(26)-N2/guanine(27)-N2)-dimethyltransferase activity. Involved in tRNA methylation. Located in mitochondrion and nuclear inner membrane. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 68. Orthologous to human TRMT1 (tRNA methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TRM1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (691549..693261, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Vba4p Neighboring gene Cox26p Neighboring gene DNA polymerase epsilon noncatalytic subunit Neighboring gene serine/threonine protein kinase KIN1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Separate information required for nuclear and subnuclear localization: additional complexity in localizing an enzyme shared by mitochondria and nuclei. Rose AM, et al. Mol Cell Biol, 1992 Dec. PMID 1448094, Free PMC Article
    2. Isolation and characterization of the TRM1 locus, a gene essential for the N2,N2-dimethylguanosine modification of both mitochondrial and cytoplasmic tRNA in Saccharomyces cerevisiae. Ellis SR, et al. J Biol Chem, 1986 Jul 25. PMID 2426253
    3. Amino-terminal extension generated from an upstream AUG codon increases the efficiency of mitochondrial import of yeast N2,N2-dimethylguanosine-specific tRNA methyltransferases. Ellis SR, et al. Mol Cell Biol, 1989 Apr. PMID 2657400, Free PMC Article
    4. N2,N2-dimethylguanosine-specific tRNA methyltransferase contains both nuclear and mitochondrial targeting signals in Saccharomyces cerevisiae. Li JM, et al. J Cell Biol, 1989 Oct. PMID 2677019, Free PMC Article
    5. Amino-terminal extension generated from an upstream AUG codon is not required for mitochondrial import of yeast N2,N2-dimethylguanosine-specific tRNA methyltransferase. Ellis SR, et al. Proc Natl Acad Sci U S A, 1987 Aug. PMID 3299379, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine(26)-N2)-dimethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine(26)-N2/guanine(27)-N2)-dimethyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA (guanine(26)-N2/guanine(27)-N2)-dimethyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA (guanine) methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA N2-guanine methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear inner membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (guanine26-N2)-dimethyltransferase
    NP_010405.3
    • tRNA methyltransferase; produces two isoforms based on alternative translational starts; localizes to the nucleus and mitochondrion, producing N2,N2-dimethylguanosine in tRNAs; involved in the methylation of guanosine and uridine ribonucleosides in mRNA; nuclear Trm1p is evenly distributed around the inner nuclear membrane in WT, but mislocalizes as puncta near ER-nucleus junctions in spindle pole body mutants; both Trm1p inner nuclear membrane targeting and maintenance depend upon the SPB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      691549..693261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180428.3 → NP_010405.3  TPA: tRNA (guanine26-N2)-dimethyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010405.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSA6, P15565, Q9URQ7, Q9URQ8
      UniProtKB/TrEMBL
      N1PAD7
      Conserved Domains (1) summary
      TIGR00308
      Location:45 → 495
      TRM1; tRNA(guanine-26,N2-N2) methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15565.1

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