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    SHU2 Shu2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851650, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SHU2
    Official Full Name
    Shu2p
    Primary source
    SGD:S000002485
    Locus tag
    YDR078C
    See related
    AllianceGenome:SGD:S000002485; FungiDB:YDR078C; VEuPathDB:YDR078C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in DNA recombinase assembly and maintenance of rDNA. Located in site of double-strand break. Part of Shu complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SHU2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (602198..602869, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene putative DNA-dependent ATPase RAD55 Neighboring gene Sed1p Neighboring gene Pet100p Neighboring gene TFIIH complex subunit TFB5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural analysis of Shu proteins reveals a DNA binding role essential for resisting damage. Tao Y, et al. J Biol Chem, 2012 Jun 8. PMID 22465956, Free PMC Article
    2. Structural and SAXS analysis of the budding yeast SHU-complex proteins. She Z, et al. FEBS Lett, 2012 Jul 30. PMID 22749910
    3. Structural basis for the functional role of the Shu complex in homologous recombination. Zhang S, et al. Nucleic Acids Res, 2017 Dec 15. PMID 29069504, Free PMC Article
    4. The Shu complex, which contains Rad51 paralogues, promotes DNA repair through inhibition of the Srs2 anti-recombinase. Bernstein KA, et al. Mol Biol Cell, 2011 May. PMID 21372173, Free PMC Article
    5. A genetic screen for top3 suppressors in Saccharomyces cerevisiae identifies SHU1, SHU2, PSY3 and CSM2: four genes involved in error-free DNA repair. Shor E, et al. Genetics, 2005 Mar. PMID 15654096, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that Csm2, Psy3, Shu1 and Shu2 interact with each other in sequence to form a V-shape overall structure in Shu complex.
      Title: Structural basis for the functional role of the Shu complex in homologous recombination.
    2. additional mutational suppressors of toopoisomerase ii defects.
      Title: A genetic screen for top3 suppressors in Saccharomyces cerevisiae identifies SHU1, SHU2, PSY3 and CSM2: four genes involved in error-free DNA repair.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombinase assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of rDNA IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in recombinational repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in recombinational repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Shu complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Shu complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in site of double-strand break IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Shu2p
    NP_010363.1
    • Component of Shu complex (aka PCSS complex); Shu complex also includes Psy3, Csm2, Shu1, and promotes error-free DNA repair, Shu complex mediates inhibition of Srs2p function; promotes formation of Rad51p filaments; important for both mitotic and meiotic homologous recombination, and contains a conserved SWIM domain that is necessary for both

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      602198..602869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180386.1 → NP_010363.1  TPA: Shu2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010363.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZY43, B3LGJ2, C7GVQ9, C8Z4Z5, D6VS64, E7KAR8, E7LSL5, E7QCS8, P38957
      UniProtKB/TrEMBL
      N1P6I9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38957.1

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