PEX19 Pex19p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PEX19
Official Full Name: Pex19p
Primary source: SGD:S000002223
Locus tag: YDL065C
See related: AllianceGenome:SGD:S000002223; FungiDB:YDL065C; VEuPathDB:YDL065C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PAS12
Summary: Enables peroxisome membrane targeting sequence binding activity. Involved in peroxisome organization; protein exit from endoplasmic reticulum; and protein stabilization. Located in cytosol; endoplasmic reticulum; and peroxisomal membrane. Part of peroxisomal importomer complex. Used to study Zellweger syndrome. Human ortholog(s) of this gene implicated in Zellweger syndrome and peroxisome biogenesis disorder 12A. Orthologous to human PEX19 (peroxisomal biogenesis factor 19). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PEX19 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (336249..337277, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pex19 is involved in importing dually targeted tail-anchored proteins to both mitochondria and peroxisomes in S cerevisiae.
Title: Pex19 is involved in importing dually targeted tail-anchored proteins to both mitochondria and peroxisomes.
Pex19p interacts with the cargo-binding domain of Myo2p
Title: Pex19p contributes to peroxisome inheritance in the association of peroxisomes to Myo2p.
The complete pool of Pex19p is processed by farnesyltransferase in vivo and that this modification is independent of peroxisome induction or the Pex19p membrane anchor Pex3p.
Title: Farnesylation of pex19p is required for its structural integrity and function in peroxisome biogenesis.
model that Pex19p is a cellular transporter for localization of tombusvirus p33 replication protein to the host peroxisomal membranes
Title: The host Pex19p plays a role in peroxisomal localization of tombusvirus replication proteins.
Pex19p acts as a chaperone to stabilize the association of Vps1p with peroxisomes and not as a receptor involved in targeting Vps1p to peroxisomes
Title: The dynamin-like protein Vps1p of the yeast Saccharomyces cerevisiae associates with peroxisomes in a Pex19p-dependent manner.
Pex19p has a role in targeting of Pex17p, a peripheral component of the peroxisomal protein import machinery
Title: Pex19p-dependent targeting of Pex17p, a peripheral component of the peroxisomal protein import machinery.
Pex3p amino-terminal domain targets to a subdomain of the endoplasmic reticulum and initiates the formation of a preperoxisomal compartment for de novo peroxisome synthesis; peroxisome formation depends on the activity of the genes PEX14 and PEX19
Title: Pex3p initiates the formation of a preperoxisomal compartment from a subdomain of the endoplasmic reticulum in Saccharomyces cerevisiae.
The PEX19 protein enriches first at the Pex3 foci on the ER and then on the maturing peroxisomes.
Title: Contribution of the endoplasmic reticulum to peroxisome formation.
Farnesylation of Pex19 is not needed for its function in peroxisome biogenesis in S. cerevisiae.
Title: Farnesylation of Pex19p is not essential for peroxisome biogenesis in yeast and mammalian cells.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables peroxisome membrane targeting sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables peroxisome membrane targeting sequence binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ER-dependent peroxisome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome inheritance	IPI Inferred from Physical Interaction more info	PubMed
involved_in peroxisome organization	IEA Inferred from Electronic Annotation more info
involved_in protein exit from endoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into peroxisome membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into peroxisome membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein stabilization	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of peroxisomal importomer complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Pex19p

NP_010218.2

Chaperone and import receptor for newly-synthesized class I PMPs; binds peroxisomal membrane proteins (PMPs) in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane; interacts with Myo2p and contributes to peroxisome partitioning