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    short-chain dehydrogenase/reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851444, updated on 9-Dec-2024

    Summary

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    Official Full Name
    short-chain dehydrogenase/reductase
    Primary source
    SGD:S000002272
    Locus tag
    YDL114W
    See related
    AllianceGenome:SGD:S000002272; FungiDB:YDL114W; VEuPathDB:YDL114W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Orthologous to several human genes including DHRS3 (dehydrogenase/reductase 3); HSD17B11 (hydroxysteroid 17-beta dehydrogenase 11); and HSD17B13 (hydroxysteroid 17-beta dehydrogenase 13). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (255604..256530)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Nup84p Neighboring gene Iwr1p Neighboring gene Atg20p Neighboring gene tRNA (guanosine(18)-2'-O)-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fungal BLAST and Model Organism BLASTP Best Hits: new comparison resources at the Saccharomyces Genome Database (SGD). Balakrishnan R, et al. Nucleic Acids Res, 2005 Jan 1. PMID 15608219, Free PMC Article
    2. Linking functionally related genes by sensitive and quantitative characterization of genetic interaction profiles. Decourty L, et al. Proc Natl Acad Sci U S A, 2008 Apr 15. PMID 18408161, Free PMC Article
    3. Genetic interaction network of the Saccharomyces cerevisiae type 1 phosphatase Glc7. Logan MR, et al. BMC Genomics, 2008 Jul 15. PMID 18627629, Free PMC Article
    4. Functional profiling of the Saccharomyces cerevisiae genome. Giaever G, et al. Nature, 2002 Jul 25. PMID 12140549
    5. A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy. Srivas R, et al. Mol Cell, 2016 Aug 4. PMID 27453043, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    short-chain dehydrogenase/reductase
    NP_010169.1
    • Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      255604..256530
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180173.1 → NP_010169.1  TPA: short-chain dehydrogenase/reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010169.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRN6, Q07530
      UniProtKB/TrEMBL
      A6ZXL5, N1P5L3
      Conserved Domains (1) summary
      cd05339
      Location:40 → 282
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07530.1

    Gene LinkOut

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