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    ERS1 cystinosin-like protein ERS1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850438, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ERS1
    Official Full Name
    cystinosin-like protein ERS1
    Primary source
    SGD:S000000671
    Locus tag
    YCR075C
    See related
    AllianceGenome:SGD:S000000671; FungiDB:YCR075C; VEuPathDB:YCR075C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables L-cystine transmembrane transporter activity. Involved in L-cystine transport. Located in endosome; fungal-type vacuole; and plasma membrane. Used to study several diseases, including carcinoma (multiple); colorectal cancer (multiple); congenital disorder of glycosylation type IIj; cystinosis; and hypoglycemia (multiple). Human ortholog(s) of this gene implicated in cystinosis. Orthologous to human CTNS (cystinosin, lysosomal cystine transporter). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ERS1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (248033..248815, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase SSK22 Neighboring gene Sol2p Neighboring gene Ego2p Neighboring gene Fub1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ERS1 a seven transmembrane domain protein from Saccharomyces cerevisiae. Hardwick KG, et al. Nucleic Acids Res, 1990 Apr 25. PMID 2186379, Free PMC Article
    2. Disruption of a cystine transporter downregulates expression of genes involved in sulfur regulation and cellular respiration. Simpkins JA, et al. Biol Open, 2016 Jun 15. PMID 27142334, Free PMC Article
    3. ERS1 encodes a functional homologue of the human lysosomal cystine transporter. Gao XD, et al. FEBS J, 2005 May. PMID 15885099
    4. A complex genetic interaction implicates that phospholipid asymmetry and phosphate homeostasis regulate Golgi functions. Miyasaka M, et al. PLoS One, 2020. PMID 32730286, Free PMC Article
    5. Golgi membrane protein Erd1 Is essential for recycling a subset of Golgi glycosyltransferases. Sardana R, et al. Elife, 2021 Nov 25. PMID 34821548, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables L-cystine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-cystine transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-cystine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-cystine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-cystine transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in fungal-type vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cystinosin-like protein ERS1
    NP_010000.1
    • Protein involved in cystine transport; localizes to the vacuole, plasma membrane and endosome; similarity to human cystinosin, a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains; mutation is functionally complemented by human CTNS

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      248033..248815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178784.1 → NP_010000.1  TPA: cystinosin-like protein ERS1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010000.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR77, P17261
      UniProtKB/TrEMBL
      A6ZTP8, B3LUD1, C7GUX2, C8Z4G2, G2WA84, N1P970
      Conserved Domains (1) summary
      TIGR00951
      Location:2 → 248
      2A43; Lysosomal Cystine Transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17261.1

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