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    RPS14A ribosomal 40S subunit protein S14A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850397, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPS14A
    Official Full Name
    ribosomal 40S subunit protein S14A
    Primary source
    SGD:S000000627
    Locus tag
    YCR031C
    See related
    AllianceGenome:SGD:S000000627; FungiDB:YCR031C; VEuPathDB:YCR031C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CRY1; RPL59
    Summary
    Enables mRNA binding activity. Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and ribosomal small subunit assembly. Part of small-subunit processome. Human ortholog(s) of this gene implicated in chromosome 5q deletion syndrome. Orthologous to human RPS14 (ribosomal protein S14). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPS14A in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_001135.5 (177500..178220, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Syp1p Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Bph1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conserved phosphorylation hotspots in eukaryotic protein domain families. Strumillo MJ, et al. Nat Commun, 2019 Apr 29. PMID 31036831, Free PMC Article
    2. Eudistomin C, an Antitumor and Antiviral Natural Product, Targets 40S Ribosome and Inhibits Protein Translation. Ota Y, et al. Chembiochem, 2016 Sep 2. PMID 27304596
    3. Molecular cloning and biosynthetic regulation of cry1 gene of Saccharomyces cerevisiae. Himmelfarb HJ, et al. Mol Gen Genet, 1984. PMID 6088947
    4. Genetics and biochemistry of cryptopleurine resistance in the yeast Saccharomyces cerevisiae. Sánchez L, et al. Mol Gen Genet, 1977 Nov 18. PMID 340910
    5. Altered response to growth rate changes in Kluyveromyces lactis versus Saccharomyces cerevisiae as demonstrated by heterologous expression of ribosomal protein 59 (CRY1). Larson GP, et al. Nucleic Acids Res, 1991 Sep 11. PMID 1891361, Free PMC Article

    See all (111) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fap7 chaperones Rps14 assembly into pre-40S particles via RNA mimicry in an ATP-dependent manner.
      Title: RNA mimicry by the fap7 adenylate kinase in ribosome biogenesis.
    2. Fap7 mediates cleavage of the 20S pre-rRNA at site D by directly interacting with Rps14
      Title: The putative NTPase Fap7 mediates cytoplasmic 20S pre-rRNA processing through a direct interaction with Rps14.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of 90S preribosome HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribosomal 40S subunit protein S14A
    NP_009960.2
    • Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14A has a paralog, RPS14B, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      177500..178220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178745.1 → NP_009960.2  TPA: ribosomal 40S subunit protein S14A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009960.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR41, P06367, Q96VG9
      UniProtKB/TrEMBL
      A6ZTL2, B3LUA2, C8Z4C1, G2WA49, N1P7V9
      Conserved Domains (1) summary
      PTZ00129
      Location:6 → 126
      PTZ00129; 40S ribosomal protein S14; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06367.5

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