SAF1 SCF ubiquitin ligase complex subunit SAF1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: SAF1
Official Full Name: SCF ubiquitin ligase complex subunit SAF1
Primary source: SGD:S000000484
Locus tag: YBR280C
See related: AllianceGenome:SGD:S000000484; FungiDB:YBR280C; VEuPathDB:YBR280C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to ubiquitin-protein transferase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Part of SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Saf1 does not require a conventional degron as do other F-box proteins but instead recognizes the catalytic site itself.
Title: Prb1 Protease Activity Is Required for Its Recognition by the F-Box Protein Saf1.
Saf1 selectively promotes ubiquitination of the unprocessed form of the zymogen. This suggests that Saf1 is part of a pathway that targets protein precursors for proteasomal degradation.
Title: Ubiquitin ligase trapping identifies an SCF(Saf1) pathway targeting unprocessed vacuolar/lysosomal proteins.
Saf1p is being a bona fide Skp1-Cullin-F-box subunit
Title: Skp1-Cullin-F-box-dependent degradation of Aah1p requires its interaction with the F-box protein Saf1p.
Saf1p targets Aah1p for proteasome-dependent degradation upon entry into quiescence.
Title: Proteasome- and SCF-dependent degradation of yeast adenine deaminase upon transition from proliferation to quiescence requires a new F-box protein named Saf1p.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to ubiquitin-protein transferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
part_of SCF ubiquitin ligase complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of SCF ubiquitin ligase complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

NP_009839.4

F-Box protein involved in proteasome-dependent degradation of Aah1p; involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1

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