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    VVS1 Vvs1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852543, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VVS1
    Official Full Name
    Vvs1p
    Primary source
    SGD:S000000445
    Locus tag
    YBR241C
    See related
    AllianceGenome:SGD:S000000445; FungiDB:YBR241C; VEuPathDB:YBR241C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable hexose transmembrane transporter activity. Predicted to be involved in monosaccharide transmembrane transport. Located in fungal-type vacuole membrane. Human ortholog(s) of this gene implicated in epilepsy (multiple); glucose metabolism disease (multiple); glycogen storage disease; myelomeningocele; and obesity. Orthologous to several human genes including SLC2A3 (solute carrier family 2 member 3) and SLC2A4 (solute carrier family 2 member 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VVS1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (702589..704055, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Ert1p Neighboring gene Thi2p Neighboring gene 5'-deoxynucleotidase Neighboring gene UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A phylogenetic analysis of the sugar porters in hemiascomycetous yeasts. Palma M, et al. J Mol Microbiol Biotechnol, 2007. PMID 17587872
    2. Organelle acidification is important for localisation of vacuolar proteins in Saccharomyces cerevisiae. Matsumoto R, et al. Protoplasma, 2013 Dec. PMID 23708375
    3. The yeast vacuolar membrane proteome. Wiederhold E, et al. Mol Cell Proteomics, 2009 Feb. PMID 19001347
    4. Complete DNA sequence of yeast chromosome II. Feldmann H, et al. EMBO J, 1994 Dec 15. PMID 7813418, Free PMC Article
    5. Misregulation of cell cycle-dependent methylation of budding yeast CENP-A contributes to chromosomal instability. Mishra PK, et al. Mol Biol Cell, 2023 Sep 1. PMID 37436802, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hexose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hexose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monosaccharide transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vvs1p
    NP_009800.1
    • Putative transporter, member of the sugar porter family; localizes to the vacuolar membrane; non-essential gene; upregulated by and required for tolerance to 4-Methylcyclohexane methanol; YBR241C has a paralog, VPS73, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      702589..704055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178589.1 → NP_009800.1  TPA: Vvs1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009800.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQN7, P38142, Q6B2Y5
      UniProtKB/TrEMBL
      B3LMS1, B5VEJ1, C7GMR3, D3UEY9, N1P743
      Conserved Domains (1) summary
      cd17357
      Location:28 → 478
      MFS_GLUT_Class1_2_like; Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38142.1

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