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    PIN4 Pin4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852229, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PIN4
    Official Full Name
    Pin4p
    Primary source
    SGD:S000000147
    Locus tag
    YBL051C
    See related
    AllianceGenome:SGD:S000000147; FungiDB:YBL051C; VEuPathDB:YBL051C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MDT1
    Summary
    Enables mRNA binding activity. Involved in DNA damage checkpoint signaling and G2/M transition of mitotic cell cycle. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PIN4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (122753..124759, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Tod6p Neighboring gene histone acetyltransferase Neighboring gene Sec17p Neighboring gene Moh1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FHA domain-ligand interactions: importance of integrating chemical and biological approaches. Mahajan A, et al. J Am Chem Soc, 2005 Oct 26. PMID 16231900
    2. In Silico Engineering of Synthetic Binding Proteins from Random Amino Acid Sequences. Burnside D, et al. iScience, 2019 Jan 25. PMID 30660105, Free PMC Article
    3. Prion-promoted phosphorylation of heterologous amyloid is coupled with ubiquitin-proteasome system inhibition and toxicity. Yang Z, et al. Mol Microbiol, 2014 Sep. PMID 25039275, Free PMC Article
    4. Mdt1, a novel Rad53 FHA1 domain-interacting protein, modulates DNA damage tolerance and G(2)/M cell cycle progression in Saccharomyces cerevisiae. Pike BL, et al. Mol Cell Biol, 2004 Apr. PMID 15024067, Free PMC Article
    5. Dual functions of Mdt1 in genome maintenance and cell integrity pathways in Saccharomyces cerevisiae. Traven A, et al. Yeast, 2010 Jan. PMID 19894211

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of PIN4 Suppresses the Protein Transport Defects Caused by sec12-4 Mutation in Saccharomyces cerevisiae.
      Title: Deletion of PIN4 Suppresses the Protein Transport Defects Caused by sec12-4 Mutation in Saccharomyces cerevisiae.
    2. [PIN+] drives Pin4C into a toxic hyperphosphorylated species.
      Title: Prion-promoted phosphorylation of heterologous amyloid is coupled with ubiquitin-proteasome system inhibition and toxicity.
    3. The results indicate that Mdt1 has partially separable functions in both cell wall and genome integrity pathways.
      Title: Dual functions of Mdt1 in genome maintenance and cell integrity pathways in Saccharomyces cerevisiae.
    4. Mdt1 facilitates efficient repair of blocked DNA double-strand breaks and recombinational maintenance of telomeres.
      Title: Mdt1 facilitates efficient repair of blocked DNA double-strand breaks and recombinational maintenance of telomeres.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in DNA damage checkpoint signaling IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Pin4p
    NP_009502.1
    • Protein involved in G2/M phase progression and response to DNA damage; interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      122753..124759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178291.1 → NP_009502.1  TPA: Pin4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009502.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPU8, P34217
      UniProtKB/TrEMBL
      N1P8R4
      Conserved Domains (2) summary
      cd02639
      Location:305 → 367
      R3H_RRM; R3H domain of mainly fungal proteins which are associated with a RNA recognition motif (RRM) domain. Present in this group is the RNA-binding post-transcriptional regulator Cip2 (Csx1-interacting protein 2) involved in counteracting Csx1 function. Csx1 ...
      cd12253
      Location:84 → 162
      RRM_PIN4_like; RNA recognition motif (RRM) found in yeast RNA-binding protein PIN4, fission yeast RNA-binding post-transcriptional regulators cip1, cip2 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34217.1

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