MRN1 Mrn1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: MRN1
Official Full Name: Mrn1p
Primary source: SGD:S000006105
Locus tag: YPL184C
See related: AllianceGenome:SGD:S000006105; FungiDB:YPL184C; VEuPathDB:YPL184C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PTR69
Summary: Enables mRNA 3'-UTR binding activity. Involved in several processes, including 3'-UTR-mediated mRNA destabilization; cellular response to cell wall damage; and mRNA splicing, via spliceosome. Located in P-body and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

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Dynamic post-transcriptional regulation by Mrn1 links cell wall homeostasis to mitochondrial structure and function.
Title: Dynamic post-transcriptional regulation by Mrn1 links cell wall homeostasis to mitochondrial structure and function.
MRN1 implicates chromatin remodeling complexes and architectural factors in mRNA maturation.
Title: MRN1 implicates chromatin remodeling complexes and architectural factors in mRNA maturation.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	HDA more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA destabilization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in 3'-UTR-mediated mRNA destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to cell wall damage	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to cell wall damage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	HDA more info	PubMed
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

NP_015140.1

mRNA-binding protein; binds to the 3'UTR of cell wall-related mRNAs and destabilizes these mRNAs during stress, acting antagonistically to Nab6p; links cell wall homeostasis to mitochondrial structure and function; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation

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