ELG1 Elg1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ELG1
Official Full Name: Elg1p
Primary source: SGD:S000005670
Locus tag: YOR144C
See related: AllianceGenome:SGD:S000005670; FungiDB:YOR144C; VEuPathDB:YOR144C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: RTT110
Summary: Enables chromatin binding activity. Involved in several processes, including DNA clamp unloading; DNA metabolic process; and heterochromatin formation. Located in mitochondrion and nucleus. Part of Elg1 RFC-like complex. Orthologous to human ATAD5 (ATPase family AAA domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ELG1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (602717..605092, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structure of the PCNA unloader Elg1-RFC.
Title: Structure of the PCNA unloader Elg1-RFC.
Timely removal of PCNA from DNA by the Elg1 complex is important to prevent mutations. The mutator phenotype of elg1Delta is attenuated by PCNA mutants that spontaneously fall off DNA. The elg1Delta mutator phenotype is exacerbated by PCNA mutants that accumulate on DNA due to enhanced electrostatic PCNA-DNA interactions.
Title: Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex.
We find that the major cause of the chromatin organization defects of an ELG1 mutant is PCNA retention on DNA following replication, with Rtt106-Elg1 interaction potentially playing a contributory role.
Title: Identification of Elg1 interaction partners and effects on post-replication chromatin re-formation.
proliferating cell nuclear antigen (PCNA) unloading activity of Elg1 is important for coordinating DNA replication forks with the process of replication-coupled nucleosome assembly to maintain silencing of HML and HMR through S-phase
Title: Pivotal roles of PCNA loading and unloading in heterochromatin function.
the various roles of Elg1 in genome stability maintenance involve the unloading of both modified and unmodified PCNA.
Title: A structure-function analysis of the yeast Elg1 protein reveals the importance of PCNA unloading in genome stability maintenance.
results suggest that Elg1-RLC acts as a general PCNA unloader and is dependent upon DNA ligation during chromosome replication.
Title: Replication-Coupled PCNA Unloading by the Elg1 Complex Occurs Genome-wide and Requires Okazaki Fragment Ligation.
ELG1 deletion from pds5-1 mutant cells results in a significant rescue of chromatid cohesion, but not condensation, defects
Title: Pds5 regulators segregate cohesion and condensation pathways in Saccharomyces cerevisiae.
A high copy number suppressor screen was performed to search for genes that, when overexpressed, suppress the synthetic lethality between elg1Delta and srs2Delta mutants.
Title: A genetic screen for high copy number suppressors of the synthetic lethality between elg1Δ and srs2Δ in yeast.
Elg1 physically contacts the Mhf1/Mhf2 histone-like complex and genetically interacts with MPH1 (ortholog of the FANCM helicase) and CHL1 (ortholog of the FANCJ helicase) genes.
Title: Genetic and physical interactions between the yeast ELG1 gene and orthologs of the Fanconi anemia pathway.
Elg1-replication factor C-like complex functions in unloading of both unmodified and SUMOylated PCNA during DNA replication.
Title: The Elg1 replication factor C-like complex functions in PCNA unloading during DNA replication.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA clamp unloading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA-templated DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid cohesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transposable element silencing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Elg1 RFC-like complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Elg1p

NP_014787.3

Subunit of an alternative replication factor C complex; important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

602717..605092 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183563.3 → NP_014787.3 TPA: Elg1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014787.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2K2, O94148, Q03129, Q12050, Q7LI57

UniProtKB/TrEMBL

C7GN79, N1NVT2

Conserved Domains (1) summary

PRK04195
Location:335 → 508

PRK04195; replication factor C large subunit; Provisional