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    WSC3 Wsc3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854046, updated on 9-Dec-2024

    Summary

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    Official Symbol
    WSC3
    Official Full Name
    Wsc3p
    Primary source
    SGD:S000005465
    Locus tag
    YOL105C
    See related
    AllianceGenome:SGD:S000005465; FungiDB:YOL105C; VEuPathDB:YOL105C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables transmembrane signaling receptor activity. Involved in Rho protein signal transduction; pexophagy; and response to heat. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See WSC3 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (114138..115808, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tRNA-Thr Neighboring gene Ndj1p Neighboring gene gag protein Neighboring gene gag-pol fusion protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tolerant industrial yeast Saccharomyces cerevisiae posses a more robust cell wall integrity signaling pathway against 2-furaldehyde and 5-(hydroxymethyl)-2-furaldehyde. Liu ZL, et al. J Biotechnol, 2018 Jun 20. PMID 29665400
    2. Distinct TORC1 signalling branches regulate Adc17 proteasome assembly chaperone expression. Williams TD, et al. J Cell Sci, 2024 Jul 15. PMID 38949052, Free PMC Article
    3. Characterization of the Wsc1 protein, a putative receptor in the stress response of Saccharomyces cerevisiae. Lodder AL, et al. Genetics, 1999 Aug. PMID 10430578, Free PMC Article
    4. Activation of signaling pathways related to cell wall integrity and multidrug resistance by organic solvent in Saccharomyces cerevisiae. Nishida N, et al. Curr Genet, 2014 Aug. PMID 24378717
    5. A novel role for the mating type (MAT) locus in the maintenance of cell wall integrity in Saccharomyces cerevisiae. Verna J, et al. Mol Gen Genet, 1999 Jun. PMID 10394905

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Protein Interactions of the Mechanosensory Proteins Wsc2 and Wsc3 for Stress Resistance in Saccharomyces cerevisiae.
      Title: Protein Interactions of the Mechanosensory Proteins Wsc2 and Wsc3 for Stress Resistance in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables transmembrane signaling receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pexophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in mating projection tip HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Wsc3p
    NP_014536.1
    • Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity; involved in response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis; WSC3 has a paralog, WSC2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      114138..115808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183359.1 → NP_014536.1  TPA: Wsc3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014536.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1W1, Q12215, Q2VQX5
      UniProtKB/TrEMBL
      A6ZNA4, B3LIV9, C7GRV7, N1P3Z3
      Conserved Domains (1) summary
      smart00321
      Location:39 → 132
      WSC; present in yeast cell wall integrity and stress response component proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12215.1

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