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    AAC1 ADP/ATP carrier protein AAC1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855078, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AAC1
    Official Full Name
    ADP/ATP carrier protein AAC1
    Primary source
    SGD:S000004660
    Locus tag
    YMR056C
    See related
    AllianceGenome:SGD:S000004660; FungiDB:YMR056C; VEuPathDB:YMR056C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ATP:ADP antiporter activity. Involved in several processes, including aerobic respiration; heme biosynthetic process; and heme transport. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); mitochondrial DNA depletion syndrome (multiple); and mitochondrial myopathy (multiple). Orthologous to several human genes including SLC25A4 (solute carrier family 25 member 4) and SLC25A5 (solute carrier family 25 member 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AAC1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (387315..388244, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene H(+)-transporting V0 sector ATPase subunit a Neighboring gene Bub2p Neighboring gene ferroxidase FET3 Neighboring gene Sen15p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The delivery of ADP/ATP carrier protein to mitochondria probed by fusions with green fluorescent protein and beta-galactosidase. Polcicová K, et al. FEMS Yeast Res, 2003 Dec. PMID 14654436
    2. A Klaac null mutant of Kluyveromyces lactis is complemented by a single copy of the Saccharomyces cerevisiae AAC1 gene. Viola AM, et al. Curr Genet, 1999 Aug. PMID 10447592
    3. Difference between yeast and bovine mitochondrial ADP/ATP carriers in terms of conformational properties of the first matrix loop as deduced by use of copper-o-phenanthroline. Kihira Y, et al. Biol Pharm Bull, 2007 May. PMID 17473430
    4. A cryptic matrix targeting signal of the yeast ADP/ATP carrier normally inserted by the TIM22 complex is recognized by the TIM23 machinery. Vergnolle MA, et al. Biochem J, 2005 Jan 1. PMID 15320873, Free PMC Article
    5. Structure-function studies of adenine nucleotide transport in mitochondria. I. Construction and genetic analysis of yeast mutants encoding the ADP/ATP carrier protein of mitochondria. Lawson JE, et al. J Biol Chem, 1990 Aug 25. PMID 2167308

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. all Cys residues that replaced 9 continuous amino acids in Met310-Lys318 showed high reactivity with eosin 5-maleimde regardless of presence of carboxyatractyloside or bongkrekate; this region was concluded to be exposed to water-accessible environment.
      Title: Functionally important conserved length of C-terminal regions of yeast and bovine ADP/ATP carriers, identified by deletion mutants studies, and water accessibility of the amino acids at the C-terminal region of the yeast carrier.
    2. AAC contains a cryptic matrix targeting signal that can target up to two thirds of the N-terminal part of the protein to the matrix, and this event is coordinated by the TIM23 translocase
      Title: A cryptic matrix targeting signal of the yeast ADP/ATP carrier normally inserted by the TIM22 complex is recognized by the TIM23 machinery.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP:ADP antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP:ADP antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in heme biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in heme transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial ADP transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial ATP transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ADP/ATP carrier protein AAC1
    NP_013772.1
    • Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      387315..388244 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182554.1 → NP_013772.1  TPA: ADP/ATP carrier protein AAC1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013772.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZN1, P04710
      UniProtKB/TrEMBL
      A6ZMB6, B3LLV0, B5VPI5, C7GL67, C8ZEQ9, G2WKA5
      Conserved Domains (1) summary
      PTZ00169
      Location:9 → 303
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04710.1

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