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    MFT1 Mft1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854940, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MFT1
    Official Full Name
    Mft1p
    Primary source
    SGD:S000004527
    Locus tag
    YML062C
    See related
    AllianceGenome:SGD:S000004527; FungiDB:YML062C; VEuPathDB:YML062C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MFT52
    Summary
    Enables molecular adaptor activity and nucleic acid binding activity. Involved in DNA recombination; mRNA export from nucleus; and transcription elongation by RNA polymerase II. Located in chromosome, telomeric region. Part of THO complex part of transcription export complex and nucleoplasmic THO complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MFT1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (147505..148683, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Ras family GTPase TEM1 Neighboring gene ribosomal 40S subunit protein S1B Neighboring gene DNA helicase PIF1 Neighboring gene 8-oxoguanine glycosylase OGG1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial protein import: isolation and characterization of the Saccharomyces cerevisiae MFT1 gene. Garrett JM, et al. Mol Gen Genet, 1991 Mar. PMID 2017143
    2. Mft52, an acid-bristle protein in the cytosol that delivers precursor proteins to yeast mitochondria. Cartwright P, et al. J Biol Chem, 1997 Feb 21. PMID 9030606
    3. The protein encoded by the MFT1 gene is a targeting factor for mitochondrial precursor proteins, and not a core ribosomal protein. Beilharz T, et al. FEBS Lett, 1997 Apr 28. PMID 9166903
    4. Mft1, identified from a genome-wide screen of the yeast haploid mutants, mediates cell cycle arrest to counteract quinoxaline-induced toxicity. Sulaiman AA, et al. Front Genet, 2023. PMID 38283148, Free PMC Article
    5. An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination. Huertas P, et al. Mol Cell Biol, 2006 Oct. PMID 16908536, Free PMC Article

    See all (126) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nucleic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of THO complex part of transcription export complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of THO complex part of transcription export complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleoplasmic THO complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mft1p
    NP_013649.1
    • Subunit of the THO complex; THO is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      147505..148683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182421.1 → NP_013649.1  TPA: Mft1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013649.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZB1, P33441
      UniProtKB/TrEMBL
      A6ZM03, B3LLJ3, B5VP70, C7GVZ8, C8ZEE3, G2WJZ3
      Conserved Domains (1) summary
      pfam05615
      Location:57 → 159
      THOC7; Tho complex subunit 7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33441.1

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