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    MDM30 SCF ubiquitin ligase complex subunit MDM30 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851083, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MDM30
    Official Full Name
    SCF ubiquitin ligase complex subunit MDM30
    Primary source
    SGD:S000004360
    Locus tag
    YLR368W
    See related
    AllianceGenome:SGD:S000004360; FungiDB:YLR368W; VEuPathDB:YLR368W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DSG1
    Summary
    Contributes to ubiquitin-protein transferase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; mitochondrial fusion; and regulation of mRNA export from nucleus. Located in mitochondrion and nucleus. Part of SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MDM30 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (857540..859336)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ribosomal 40S subunit protein S22B Neighboring gene ncRNA Neighboring gene Hsp70 family ATPase SSQ1 Neighboring gene Arc18p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stimulation of mRNA export by an F-box protein, Mdm30p, in vivo. Shukla A, et al. J Mol Biol, 2009 Jun 5. PMID 19376128
    2. Instability of the mitofusin Fzo1 regulates mitochondrial morphology during the mating response of the yeast Saccharomyces cerevisiae. Neutzner A, et al. J Biol Chem, 2005 May 13. PMID 15760898
    3. Nonredundant roles of mitochondria-associated F-box proteins Mfb1 and Mdm30 in maintenance of mitochondrial morphology in yeast. Dürr M, et al. Mol Biol Cell, 2006 Sep. PMID 16790496, Free PMC Article
    4. An F-Box Protein, Mdm30, Interacts with TREX Subunit Sub2 To Regulate Cellular Abundance Cotranscriptionally in Orchestrating mRNA Export Independently of Splicing and Mitochondrial Function. Ferdoush J, et al. Mol Cell Biol, 2020 Mar 16. PMID 31932480, Free PMC Article
    5. A proteomic screen reveals the mitochondrial outer membrane protein Mdm34p as an essential target of the F-box protein Mdm30p. Ota K, et al. Genes Cells, 2008 Oct. PMID 18775025

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mdm30 interacts with Sub2 for proteasomal degradation in a transcription-dependent manner to promote mRNA export independently of splicing or mitochondrial function, thus advancing understanding of mRNA export.
      Title: An F-Box Protein, Mdm30, Interacts with TREX Subunit Sub2 To Regulate Cellular Abundance Cotranscriptionally in Orchestrating mRNA Export Independently of Splicing and Mitochondrial Function.
    2. Rsp5 and Mdm30 reshape the mitochondrial network in response to age-induced vacuole stress in Saccharomyces cerevisiae.
      Title: Rsp5 and Mdm30 reshape the mitochondrial network in response to age-induced vacuole stress.
    3. Mdm30-Ubp2-Rsp5 crosstalk regulates mitochondrial fusion by coordinating an intricate balance between Fzo1 turnover and the status of fatty acids saturation.
      Title: An ubiquitin-dependent balance between mitofusin turnover and fatty acids desaturation regulates mitochondrial fusion.
    4. Mdm30 promotes mRNA export by lowering Sub2's stability and consequently enhancing Yra1 recruitment.
      Title: A new regulatory pathway of mRNA export by an F-box protein, Mdm30.
    5. Findings suggest a sequence of events in early mitochondrial fusion where Fzo1 GTPase-domain-dependent tethering leads to recruitment of SCF(Mdm30) and ubiquitin-mediated degradation of Fzo1, which facilitates mitochondrial fusion.
      Title: Sequential requirements for the GTPase domain of the mitofusin Fzo1 and the ubiquitin ligase SCFMdm30 in mitochondrial outer membrane fusion.
    6. Mdm30-dependent degradation of Fzo1 completes Fzo1 function in mitochondrial outer membrane fusion.
      Title: Ugo1 and Mdm30 act sequentially during Fzo1-mediated mitochondrial outer membrane fusion.
    7. These results suggest that the Dsg1-mediated efficient transcription process of GAL genes may depend on the interaction status between Gal4p and Gal80p.
      Title: Alterations in the interaction between GAL4 and GAL80 effect regulation of the yeast GAL regulon mediated by the F box protein Dsg1.
    8. Mdm30p selectively controls mRNA export independently of mitochondrial fusion, revealing a novel function of an F-box protein in mRNA export.
      Title: Stimulation of mRNA export by an F-box protein, Mdm30p, in vivo.
    9. We identified the mitochondrial outer membrane protein Mdm34p as a target of Mdm30p.
      Title: A proteomic screen reveals the mitochondrial outer membrane protein Mdm34p as an essential target of the F-box protein Mdm30p.
    10. Destruction of transcriptionally active Gal4 depends on an F box protein called Dsg1/Mdm30.
      Title: The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to ubiquitin-protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in mitochondrial fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis involved in protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    SCF ubiquitin ligase complex subunit MDM30
    NP_013472.3
    • F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      857540..859336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182257.3 → NP_013472.3  TPA: SCF ubiquitin ligase complex subunit MDM30 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013472.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ05, Q05930
      UniProtKB/TrEMBL
      A7A1P5, G2WJI5, N1P1Q7
      Conserved Domains (1) summary
      pfam12937
      Location:16 → 60
      F-box-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05930.1

    Gene LinkOut

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