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    GPR85 G protein-coupled receptor 85 [ Homo sapiens (human) ]

    Gene ID: 54329, updated on 3-Dec-2024

    Summary

    Official Symbol
    GPR85provided by HGNC
    Official Full Name
    G protein-coupled receptor 85provided by HGNC
    Primary source
    HGNC:HGNC:4536
    See related
    Ensembl:ENSG00000164604 MIM:605188; AllianceGenome:HGNC:4536
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SREB; SREB2
    Summary
    Members of the G protein-coupled receptor (GPCR) family, such as GPR85, have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli, such as neurotransmitters, hormones, or light, induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins (Matsumoto et al., 2000 [PubMed 10833454]).[supplied by OMIM, Aug 2008]
    Expression
    Biased expression in brain (RPKM 3.3), testis (RPKM 1.1) and 12 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GPR85 in Genome Data Viewer
    Location:
    7q31.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (113082285..113087724, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (114401309..114406733, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (112722340..112727779, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26517 Neighboring gene S-adenosylmethionine sensor upstream of mTORC1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26518 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26519 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:112556531-112557032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:112557033-112557532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18545 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:112579888-112580404 Neighboring gene heart tissue-associated transcript 17 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18546 Neighboring gene uncharacterized LOC107986837 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:112758380-112758974 Neighboring gene small integral membrane protein 30 Neighboring gene NANOG hESC enhancer GRCh37_chr7:112828377-112828990 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:112902892-112903479 Neighboring gene NANOG hESC enhancer GRCh37_chr7:113061672-113062194 Neighboring gene uncharacterized LOC124901813

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of G protein-coupled receptor 85 (GPR85) in primary human brain microvascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • FLJ50993, FLJ51159, FLJ99433

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    probable G-protein coupled receptor 85
    Names
    seven transmembrane helix receptor
    super conserved receptor expressed in brain 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146265.2NP_001139737.1  probable G-protein coupled receptor 85

      See identical proteins and their annotated locations for NP_001139737.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All variants (1-4) encode the same protein.
      Source sequence(s)
      AC073346
      Consensus CDS
      CCDS5758.1
      UniProtKB/Swiss-Prot
      P60893, Q9JHI6, Q9NPD1
      UniProtKB/TrEMBL
      A4D0T8, Q8NEN2
      Related
      ENSP00000297146.2, ENST00000297146.7
      Conserved Domains (1) summary
      cd15218
      Location:21350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001146266.2NP_001139738.1  probable G-protein coupled receptor 85

      See identical proteins and their annotated locations for NP_001139738.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein.
      Source sequence(s)
      AC073346
      Consensus CDS
      CCDS5758.1
      UniProtKB/Swiss-Prot
      P60893, Q9JHI6, Q9NPD1
      UniProtKB/TrEMBL
      A4D0T8, Q8NEN2
      Related
      ENSP00000401178.1, ENST00000449591.2
      Conserved Domains (1) summary
      cd15218
      Location:21350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors
    3. NM_001146267.2NP_001139739.1  probable G-protein coupled receptor 85

      See identical proteins and their annotated locations for NP_001139739.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein.
      Source sequence(s)
      AC073346
      Consensus CDS
      CCDS5758.1
      UniProtKB/Swiss-Prot
      P60893, Q9JHI6, Q9NPD1
      UniProtKB/TrEMBL
      A4D0T8, Q8NEN2
      Related
      ENSP00000396763.1, ENST00000424100.2
      Conserved Domains (1) summary
      cd15218
      Location:21350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors
    4. NM_018970.7NP_061843.3  probable G-protein coupled receptor 85

      See identical proteins and their annotated locations for NP_061843.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein.
      Source sequence(s)
      AC073346
      Consensus CDS
      CCDS5758.1
      UniProtKB/Swiss-Prot
      P60893, Q9JHI6, Q9NPD1
      UniProtKB/TrEMBL
      A4D0T8, Q8NEN2
      Conserved Domains (1) summary
      cd15218
      Location:21350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      113082285..113087724 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005250451.3XP_005250508.1  probable G-protein coupled receptor 85 isoform X1

      See identical proteins and their annotated locations for XP_005250508.1

      UniProtKB/Swiss-Prot
      P60893, Q9JHI6, Q9NPD1
      UniProtKB/TrEMBL
      A4D0T8, Q8NEN2
      Conserved Domains (1) summary
      cd15218
      Location:21350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors
    2. XM_017012352.3XP_016867841.1  probable G-protein coupled receptor 85 isoform X1

      UniProtKB/Swiss-Prot
      P60893, Q9JHI6, Q9NPD1
      UniProtKB/TrEMBL
      A4D0T8, Q8NEN2
      Conserved Domains (1) summary
      cd15218
      Location:21350
      7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      114401309..114406733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358466.1XP_054214441.1  probable G-protein coupled receptor 85 isoform X1

      UniProtKB/Swiss-Prot
      P60893, Q9JHI6, Q9NPD1
      UniProtKB/TrEMBL
      A4D0T8, Q8NEN2
    2. XM_054358465.1XP_054214440.1  probable G-protein coupled receptor 85 isoform X1

      UniProtKB/Swiss-Prot
      P60893, Q9JHI6, Q9NPD1
      UniProtKB/TrEMBL
      A4D0T8, Q8NEN2