Ptpn4 protein tyrosine phosphatase, non-receptor type 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptpn4provided by MGI
Official Full Name: protein tyrosine phosphatase, non-receptor type 4provided by MGI
Primary source: MGI:MGI:1099792
See related: Ensembl:ENSMUSG00000026384 AllianceGenome:MGI:1099792
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TEP; Ptn4; PTPMEG; hPTP-MEG; TEP/mPTPMEG
Summary: Enables glutamate receptor binding activity and non-membrane spanning protein tyrosine phosphatase activity. Acts upstream of or within peptidyl-tyrosine phosphorylation. Located in membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; immune system; and respiratory system. Orthologous to human PTPN4 (protein tyrosine phosphatase non-receptor type 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cerebellum adult (RPKM 7.2), frontal lobe adult (RPKM 5.7) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E2.3; 1 52.39 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (119580197..119765281, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (119652467..119837585, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

E3 Ubiquitin Ligase MARCH8 Promotes Pancreatic Cancer Growth and Metastasis by Activating STAT3 via Degradation of PTPN4.
Title: E3 Ubiquitin Ligase MARCH8 Promotes Pancreatic Cancer Growth and Metastasis by Activating STAT3 via Degradation of PTPN4.
Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG.
Title: Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG.
our results provide new insight into the TLR4 pathway and identify PTPN4 as a specific inhibitor of TRIF-dependent TLR4 pathway.
Title: Phosphatase PTPN4 preferentially inhibits TRIF-dependent TLR4 pathway by dephosphorylating TRAM.
PTPN3 and PTPN4 are dispensable for TCR signal transduction.
Title: The FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are both dispensable for T cell receptor signal transduction.
Tyrosine dephosphorylation events regulated by PTPMEG are important for both motor learning and cerebellar synaptic plasticity.
Title: Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info
enables glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tyrosine-protein phosphatase non-receptor type 4

Names: testis-enriched protein tyrosine phosphatase

NP_064317.2

EC 3.1.3.48

XP_006529316.1

EC 3.1.3.48

XP_006529317.1

EC 3.1.3.48

XP_006529318.1

EC 3.1.3.48

XP_006529319.1

EC 3.1.3.48

XP_030108159.1

EC 3.1.3.48

XP_030108161.1

EC 3.1.3.48

XP_030108162.1

EC 3.1.3.48

XP_030108163.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019933.2 → NP_064317.2 tyrosine-protein phosphatase non-receptor type 4

See identical proteins and their annotated locations for NP_064317.2

Status: VALIDATED

Source sequence(s)

AC123955, AF106702, AK046683, AK166169, BE985496

Consensus CDS

CCDS15227.1

UniProtKB/Swiss-Prot

G5E8E7, Q9WU22

Related

ENSMUSP00000067614.6, ENSMUST00000064091.12

Conserved Domains (8) summary

smart00194
Location:657 → 910

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00295
Location:30 → 222

B41; Band 4.1 homologues

cd00047
Location:682 → 909

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00992
Location:515 → 602

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:216 → 310

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

pfam00373
Location:115 → 222

FERM_M; FERM central domain

pfam08736
Location:325 → 365

FA; FERM adjacent (FA)

pfam09379
Location:33 → 97

FERM_N; FERM N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

119580197..119765281 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529253.5 → XP_006529316.1 tyrosine-protein phosphatase non-receptor type 4 isoform X1

Conserved Domains (6) summary

cd00992
Location:500 → 587

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:201 → 295

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

cd17194
Location:28 → 111

FERM_F1_PTPN4; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in tyrosine-protein phosphatase non-receptor type 4 (PTPN4)

pfam00373
Location:113 → 207

FERM_M; FERM central domain

pfam08736
Location:310 → 350

FA; FERM adjacent (FA)

cl28904
Location:626 → 899

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006529255.4 → XP_006529318.1 tyrosine-protein phosphatase non-receptor type 4 isoform X3

Conserved Domains (6) summary

smart00295
Location:48 → 171

B41; Band 4.1 homologues

cd00992
Location:464 → 551

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:165 → 259

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

pfam08736
Location:274 → 314

FA; FERM adjacent (FA)

cl28904
Location:590 → 863

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

cl28922
Location:1 → 77

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006529254.5 → XP_006529317.1 tyrosine-protein phosphatase non-receptor type 4 isoform X2

Conserved Domains (6) summary

smart00295
Location:48 → 186

B41; Band 4.1 homologues

cd00992
Location:479 → 566

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:180 → 274

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

pfam08736
Location:289 → 329

FA; FERM adjacent (FA)

cl28904
Location:605 → 878

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

cl28922
Location:1 → 77

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_030252301.2 → XP_030108161.1 tyrosine-protein phosphatase non-receptor type 4 isoform X4

Conserved Domains (4) summary

cd00992
Location:279 → 366

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam08736
Location:89 → 129

FA; FERM adjacent (FA)

cl17171
Location:1 → 74

PH-like; Pleckstrin homology-like domain

cl28904
Location:405 → 678

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_030252299.2 → XP_030108159.1 tyrosine-protein phosphatase non-receptor type 4 isoform X4

Conserved Domains (4) summary

cd00992
Location:279 → 366

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam08736
Location:89 → 129

FA; FERM adjacent (FA)

cl17171
Location:1 → 74

PH-like; Pleckstrin homology-like domain

cl28904
Location:405 → 678

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006529256.3 → XP_006529319.1 tyrosine-protein phosphatase non-receptor type 4 isoform X4

Conserved Domains (4) summary

cd00992
Location:279 → 366

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam08736
Location:89 → 129

FA; FERM adjacent (FA)

cl17171
Location:1 → 74

PH-like; Pleckstrin homology-like domain

cl28904
Location:405 → 678

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_030252302.2 → XP_030108162.1 tyrosine-protein phosphatase non-receptor type 4 isoform X5

Conserved Domains (4) summary

cd00992
Location:228 → 315

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam08736
Location:38 → 78

FA; FERM adjacent (FA)

cl17171
Location:1 → 23

PH-like; Pleckstrin homology-like domain

cl28904
Location:354 → 627

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_030252303.2 → XP_030108163.1 tyrosine-protein phosphatase non-receptor type 4 isoform X5

Conserved Domains (4) summary

cd00992
Location:228 → 315

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam08736
Location:38 → 78

FA; FERM adjacent (FA)

cl17171
Location:1 → 23

PH-like; Pleckstrin homology-like domain

cl28904
Location:354 → 627

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily