Catsper3 cation channel, sperm associated 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Catsper3provided by MGI
Official Full Name: cation channel, sperm associated 3provided by MGI
Primary source: MGI:MGI:1924106
See related: Ensembl:ENSMUSG00000021499 AllianceGenome:MGI:1924106
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CACRC; 4921522D01Rik
Summary: Enables voltage-gated calcium channel activity. Acts upstream of or within several processes, including flagellated sperm motility; sodium ion transport; and sperm capacitation. Located in acrosomal vesicle and endoplasmic reticulum. Part of CatSper complex. Is expressed in ductus deferens; epididymis; ileum; prostate gland; and testis. Orthologous to human CATSPER3 (cation channel sperm associated 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 22.1) See more
Orthologs: human all
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Genomic context

Location:: 13 B1; 13 30.06 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (55932313..55971861)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (55784500..55824048)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that Catsper1, Catsper2, Catsper3, and Catsper4 form protein multimer with hypothetical activities of flippase and disulfide isomerase.
Title: Intramembranal disulfide cross-linking elucidates the super-quaternary structure of mammalian CatSpers.
Hydrogen peroxide induced upregulation of catsper3 in brain.
Title: H2O2-induced up-regulation of CatSper3 in mouse brain.
Data show that spinal cord injury doesn't significantly change the expression of CatSpers 3.
Title: CatSper genes expression, semen characteristics and histology of testes in the contusive spinal cord-injured mice model.
Catsper3 and Catsper4 knockout male mice are completely infertile due to a quick loss of motility and a lack of hyperactivated motility under capacitating conditions.
Title: Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse.
Catsper3 has a single channel-forming domain, a pore-loop with the consensus sequence TxDxW, & a coiled-coil protein-protein interaction domain in the C-terminal tail. CatSpers 1,2,3 & 4 may interact directly or indirectly to form a functional tetramer.
Title: Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis.
CATSPER3 is a cation-channel protein and has role in acrosome reaction and male fertility
Title: Catsper3 and catsper4 encode two cation channel-like proteins exclusively expressed in the testis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in flagellated sperm motility	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sodium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm capacitation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sperm capacitation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CatSper complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CatSper complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in acrosomal vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in motile cilium	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cation channel sperm-associated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252487.1 → NP_001239416.1 cation channel sperm-associated protein 3 isoform 1

See identical proteins and their annotated locations for NP_001239416.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC129780

Consensus CDS

CCDS56885.1

UniProtKB/Swiss-Prot

Q5FWA9, Q80W99, Q9D5T9

UniProtKB/TrEMBL

E0Z0E0

Related

ENSMUSP00000021961.6, ENSMUST00000021961.12

Conserved Domains (1) summary

pfam00520
Location:49 → 269

Ion_trans; Ion transport protein
NM_001252488.1 → NP_001239417.1 cation channel sperm-associated protein 3 isoform 3

See identical proteins and their annotated locations for NP_001239417.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AC129780

UniProtKB/TrEMBL

E0Z0E1

Conserved Domains (1) summary

pfam00520
Location:100 → 218

Ion_trans; Ion transport protein
NM_029772.4 → NP_084048.1 cation channel sperm-associated protein 3 isoform 2

See identical proteins and their annotated locations for NP_084048.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AC129780, AK014942

Consensus CDS

CCDS26555.1

UniProtKB/Swiss-Prot

Q80W99

Related

ENSMUSP00000105524.3, ENSMUST00000109898.3

Conserved Domains (1) summary

pfam00520
Location:138 → 256

Ion_trans; Ion transport protein