Tnfaip1 tumor necrosis factor, alpha-induced protein 1 (endothelial) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnfaip1provided by MGI
Official Full Name: tumor necrosis factor, alpha-induced protein 1 (endothelial)provided by MGI
Primary source: MGI:MGI:104961
See related: Ensembl:ENSMUSG00000017615 AllianceGenome:MGI:104961
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Edp1; Edp-1; Tnfip1; Bacurd2
Summary: Predicted to enable cyclin binding activity; identical protein binding activity; and small GTPase binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including negative regulation of Rho protein signal transduction; positive regulation of DNA replication; and stress fiber assembly. Predicted to be located in endosome. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in brain; heart valve; peripheral nerve; sensory organ; and skeleton. Orthologous to human TNFAIP1 (TNF alpha induced protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in lung adult (RPKM 35.5), large intestine adult (RPKM 31.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 46.74 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (78413676..78427122, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (78522850..78536270, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TNFAIP1 promotes macrophage lipid accumulation and accelerates the development of atherosclerosis through the LEENE/FoxO1/ABCA1 pathway.
Title: TNFAIP1 promotes macrophage lipid accumulation and accelerates the development of atherosclerosis through the LEENE/FoxO1/ABCA1 pathway.
MiR-93 alleviates DEHP plasticizer-induced neurotoxicity by negatively regulating TNFAIP1 and inhibiting ubiquitin-mediated degradation of CK2beta.
Title: MiR-93 alleviates DEHP plasticizer-induced neurotoxicity by negatively regulating TNFAIP1 and inhibiting ubiquitin-mediated degradation of CK2β.
Knocking down TNFAIP1 alleviates inflammation and oxidative stress in pediatric pneumonia through PI3K/Akt/Nrf2 pathway.
Title: Knocking down TNFAIP1 alleviates inflammation and oxidative stress in pediatric pneumonia through PI3K/Akt/Nrf2 pathway.
TNFAIP1 Mediates Formaldehyde-Induced Neurotoxicity by Inhibiting the Akt/CREB Pathway in N2a Cells.
Title: TNFAIP1 Mediates Formaldehyde-Induced Neurotoxicity by Inhibiting the Akt/CREB Pathway in N2a Cells.
Results demonstrated that TNFAIP1 was significantly upregulated by Abeta25-35 in mouse primary cortical neurons and N2a cells, and TNFAIP1 may be a key player that mediated Abeta25-35-induced neurotoxicity by inactivating the Akt/CREB signaling pathway, and in turn downregulating anti-apoptotic protein Bcl-2.
Title: TNFAIP1 contributes to the neurotoxicity induced by Aβ25-35 in Neuro2a cells.
ABETA 25-35 downregulated miR-137 and upregulated TNFAIP1 in cortical neurons and N2a cells.
Title: miR-137 attenuates Aβ-induced neurotoxicity through inactivation of NF-κB pathway by targeting TNFAIP1 in Neuro2a cells.
Study identifies Bacurd1/Kctd13 and Bacurd2/Tnfaip1 as interacting partners to RhoA GTPase proteins which influence the development of cortical neurons.
Title: Bacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd proteins which influence the long-term positioning and dendritic maturation of cerebral cortical neurons.
Bacurd2 influences the multipolar-to-bipolar transition of radially migrating neurons in a cell autonomous fashion. Bacurd2 and Rnd2 interact to promote radial migration within the embryonic cortex.
Title: Bacurd2 is a novel interacting partner to Rnd2 which controls radial migration within the developing mammalian cerebral cortex.
Estrogen and ERbeta regulate Tnfaip1 expression in mouse hippocampus.
Title: Estrogen is a novel regulator of Tnfaip1 in mouse hippocampus.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Bhm59 (e-PCR), detects polymorphism
- UniSTS:141663

D11Bhm60 (e-PCR), detects polymorphism
- UniSTS:141665

NoName (e-PCR)
- UniSTS:236655

NoName (e-PCR)
- UniSTS:236656

D11Seg36 (e-PCR), detects polymorphism
- UniSTS:141811

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cyclin binding	IEA Inferred from Electronic Annotation more info
enables cyclin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISS Inferred from Sequence or Structural Similarity more info
contributes_to ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
contributes_to ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Rho protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA replication	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in stress fiber assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul3-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul3-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

Names: BTB/POZ domain-containing protein TNFAIP1; tumor necrosis factor induced protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159392.1 → NP_001152864.1 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

See identical proteins and their annotated locations for NP_001152864.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK034305, AK147809, AK168805, BY060883, CB205355

Consensus CDS

CCDS25110.1

UniProtKB/Swiss-Prot

O70479, Q3TH85, Q3UGQ5, Q8BV61, Q8BZK5

Related

ENSMUSP00000103912.3, ENSMUST00000108277.3

Conserved Domains (2) summary

smart00225
Location:29 → 127

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam02214
Location:30 → 120

BTB_2; BTB/POZ domain
NM_009395.4 → NP_033421.3 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

See identical proteins and their annotated locations for NP_033421.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK034305, AK147809, AK168805, BY329500, CB205355

Consensus CDS

CCDS25110.1

UniProtKB/Swiss-Prot

O70479, Q3TH85, Q3UGQ5, Q8BV61, Q8BZK5

Related

ENSMUSP00000017759.3, ENSMUST00000017759.9

Conserved Domains (2) summary

smart00225
Location:29 → 127

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam02214
Location:30 → 120

BTB_2; BTB/POZ domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

78413676..78427122 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245918.2 → XP_030101778.1 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 isoform X1

Conserved Domains (1) summary

cl38908
Location:1 → 25

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
XM_030245919.2 → XP_030101779.1 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 isoform X1

Conserved Domains (1) summary

cl38908
Location:1 → 25

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily