Muc1 mucin 1, transmembrane [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Muc1provided by MGI
Official Full Name: mucin 1, transmembraneprovided by MGI
Primary source: MGI:MGI:97231
See related: Ensembl:ENSMUSG00000042784 AllianceGenome:MGI:97231
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EMA; CD227; Muc-1
Summary: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; p53 binding activity; and transcription coregulator activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and regulation of DNA-templated transcription. Located in apical plasma membrane and cell surface. Is expressed in several structures, including alimentary system; brain; exocrine system; genitourinary system; and respiratory system. Human ortholog(s) of this gene implicated in several diseases, including allergic rhinitis; biliary tract benign neoplasm; dry eye syndrome; familial juvenile hyperuricemic nephropathy; and pancreatic cancer (multiple). Orthologous to human MUC1 (mucin 1, cell surface associated). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in stomach adult (RPKM 255.6), lung adult (RPKM 94.3) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 39.02 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (89136363..89140688)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (89229056..89233381)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MUC1 induces the accumulation of Foxp3[+] Treg cells in the tumor microenvironment to promote the growth and metastasis of cholangiocarcinoma through the EGFR/PI3K/Akt signaling pathway.
Title: MUC1 induces the accumulation of Foxp3(+) Treg cells in the tumor microenvironment to promote the growth and metastasis of cholangiocarcinoma through the EGFR/PI3K/Akt signaling pathway.
Influence of glycoprotein MUC1 on trafficking of the Ca[2+]-selective ion channels, TRPV5 and TRPV6, and on in vivo calcium homeostasis.
Title: Influence of glycoprotein MUC1 on trafficking of the Ca(2+)-selective ion channels, TRPV5 and TRPV6, and on in vivo calcium homeostasis.
A Novel Adult Murine Model of Typical Enteroaggregative Escherichia coli Infection Reveals Microbiota Dysbiosis, Mucus Secretion, and AAF/II-Mediated Expression and Localization of beta-Catenin and Expression of MUC1 in Ileum.
Title: A Novel Adult Murine Model of Typical Enteroaggregative Escherichia coli Infection Reveals Microbiota Dysbiosis, Mucus Secretion, and AAF/II-Mediated Expression and Localization of β-Catenin and Expression of MUC1 in Ileum.
MUC1 triggers lineage plasticity of Her2 positive mammary tumors.
Title: MUC1 triggers lineage plasticity of Her2 positive mammary tumors.
Recombinant nanobody against MUC1 tandem repeats inhibits growth, invasion, metastasis, and vascularization of spontaneous mouse mammary tumors.
Title: Recombinant nanobody against MUC1 tandem repeats inhibits growth, invasion, metastasis, and vascularization of spontaneous mouse mammary tumors.
Mucin1 relieves acute lung injury by inhibiting inflammation and oxidative stress.
Title: Mucin1 relieves acute lung injury by inhibiting inflammation and oxidative stress.
Comparative microanatomical and histochemical biodistribution profiles of different types of mucins in oesophageal gastric tract mucosa of some tetrapod representatives.
Title: Comparative microanatomical and histochemical biodistribution profiles of different types of mucins in oesophageal gastric tract mucosa of some tetrapod representatives.
MUC1 Promotes Mesangial Cell Proliferation and Kidney Fibrosis in Diabetic Nephropathy Through Activating STAT and beta-Catenin Signal Pathway.
Title: MUC1 Promotes Mesangial Cell Proliferation and Kidney Fibrosis in Diabetic Nephropathy Through Activating STAT and β-Catenin Signal Pathway.
KIM-1-mediated anti-inflammatory activity is preserved by MUC1 induction in the proximal tubule during ischemia-reperfusion injury.
Title: KIM-1-mediated anti-inflammatory activity is preserved by MUC1 induction in the proximal tubule during ischemia-reperfusion injury.
Modelling the Effect of MUC1 on Influenza Virus Infection Kinetics and Macrophage Dynamics.
Title: Modelling the Effect of MUC1 on Influenza Virus Infection Kinetics and Macrophage Dynamics.

Submit: New GeneRIF Correction See all GeneRIFs (82)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3Dcr14 (e-PCR), detects polymorphism
- UniSTS:507664

D3Mit49 (e-PCR), detects polymorphism
- UniSTS:129816

Muc1 (e-PCR), detects polymorphism
- UniSTS:527001

Muc1 (e-PCR), detects polymorphism
- UniSTS:516859

Muc1 (e-PCR), detects polymorphism
- UniSTS:516860

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by competitive promoter binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mucin-1

Names: episialin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.