Ltf lactotransferrin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ltfprovided by MGI
Official Full Name: lactotransferrinprovided by MGI
Primary source: MGI:MGI:96837
See related: Ensembl:ENSMUSG00000032496 AllianceGenome:MGI:96837
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lf; Csp82; Ms10r; MMS10R
Summary: Enables peptidase activity. Predicted to be involved in several processes, including defense response to other organism; regulation of macromolecule metabolic process; and regulation of signal transduction. Located in cytoplasm. Is expressed in several structures, including early conceptus; epithelium; genitourinary system; gut; and liver. Human ortholog(s) of this gene implicated in candidiasis; lung non-small cell carcinoma; and renal cell carcinoma. Orthologous to human LTF (lactotransferrin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver E18 (RPKM 57.9), ovary adult (RPKM 22.0) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F2; 9 60.79 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (110848360..110871834)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (111019292..111042766)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Clearance of Neutrophils From ICH-Affected Brain by Macrophages Is Beneficial and Is Assisted by Lactoferrin and CD91.
Title: Clearance of Neutrophils From ICH-Affected Brain by Macrophages Is Beneficial and Is Assisted by Lactoferrin and CD91.
Lactoferrin deficiency during lactation increases the risk of depressive-like behavior in adult mice.
Title: Lactoferrin deficiency during lactation increases the risk of depressive-like behavior in adult mice.
Deficiency of Lactoferrin aggravates lipopolysaccharide-induced acute inflammation via recruitment macrophage in mice.
Title: Deficiency of Lactoferrin aggravates lipopolysaccharide-induced acute inflammation via recruitment macrophage in mice.
Lactoferrin Deficiency Impairs Proliferation of Satellite Cells via Downregulating the ERK1/2 Signaling Pathway.
Title: Lactoferrin Deficiency Impairs Proliferation of Satellite Cells via Downregulating the ERK1/2 Signaling Pathway.
Salivary Lactoferrin Expression in a Mouse Model of Alzheimer's Disease.
Title: Salivary Lactoferrin Expression in a Mouse Model of Alzheimer's Disease.
Distribution of Lactoferrin Is Related with Dynamics of Neutrophils in Bacterial Infected Mice Intestine.
Title: Distribution of Lactoferrin Is Related with Dynamics of Neutrophils in Bacterial Infected Mice Intestine.
Lactoferrin can induce MDSCs differentiation and apoptosis, as well as upregulate TLR9 expression. TLR9 agonist or lactoferrin treatment can rescue this phenotype in the tumor metastasis mouse model. Our results suggest a protective role of lactoferrin in cancer metastasis, along with a deficiency in certain components of the innate immune system, may lead to a pro-metastatic tumor microenvironment.
Title: Lactoferrin deficiency induces a pro-metastatic tumor microenvironment through recruiting myeloid-derived suppressor cells in mice.
LTF mRNA was undetectable in the mouse brain, even after ICH. Unlike mRNA, LTF protein increased in ICH-affected hemispheres by 6 hours, peaked at 24 to 72 hours, and remained elevated for at least a week after ICH. At the single cell level, LTF was detected in PMNs in the hematoma-affected brain at all time points after ICH. We also found elevated LTF in the plasma after ICH.
Title: Beneficial Role of Neutrophils Through Function of Lactoferrin After Intracerebral Hemorrhage.
Hepatic Ltf prevents hepatic steatosis through inhibition of dietary lipid uptake in radiation-induced NAFLD mouse model. We also suggest coumestrol as a drug candidate for prevention of NAFLD.
Title: Decreased Hepatic Lactotransferrin Induces Hepatic Steatosis in Chronic Non-Alcoholic Fatty Liver Disease Model.
Data indicate that lactoferrin uptake across duodenum by glyceraldehyde-3-phosphate dehydrogenase (GAPDH).
Title: Secreted multifunctional Glyceraldehyde-3-phosphate dehydrogenase sequesters lactoferrin and iron into cells via a non-canonical pathway.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ltf (e-PCR), detects polymorphism
- UniSTS:472914

D9Mit38 (e-PCR), detects polymorphism
- UniSTS:131930

PMC140657P1 (e-PCR)
- UniSTS:270949

PMC24216P1 (e-PCR)
- UniSTS:272244

Ltf (e-PCR), detects polymorphism
- UniSTS:527000

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables lipopolysaccharide binding	IEA Inferred from Electronic Annotation more info
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables membrane destabilizing activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
involved_in antibacterial humoral response	ISO Inferred from Sequence Orthology more info
involved_in antibacterial humoral response	ISS Inferred from Sequence or Structural Similarity more info
involved_in antifungal humoral response	ISO Inferred from Sequence Orthology more info
involved_in antifungal humoral response	ISS Inferred from Sequence or Structural Similarity more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IEA Inferred from Electronic Annotation more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in bone morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in bone morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytolysis by host of symbiont cells	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-negative bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in innate immune response in mucosa	ISO Inferred from Sequence Orthology more info
involved_in innate immune response in mucosa	ISS Inferred from Sequence or Structural Similarity more info
involved_in iron ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron ion transport	IEA Inferred from Electronic Annotation more info
involved_in killing of cells of another organism	IEA Inferred from Electronic Annotation more info
involved_in killing of cells of another organism	ISO Inferred from Sequence Orthology more info
involved_in negative regulation by host of viral process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation by host of viral process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ATP-dependent activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipopolysaccharide-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoclast development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of single-species biofilm formation in or on host organism	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of single-species biofilm formation in or on host organism	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of tumor necrosis factor (ligand) superfamily member 11 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of viral genome replication	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral process	ISO Inferred from Sequence Orthology more info
involved_in ossification	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization involved in bone maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chondrocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chondrocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of osteoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 4 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info
located_in specific granule	ISO Inferred from Sequence Orthology more info
located_in specific granule	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: lactotransferrin

Names: N lobe; lactoferrin; minisatellite 10r detected by probe MMS10

NP_032548.2

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008522.3 → NP_032548.2 lactotransferrin precursor

See identical proteins and their annotated locations for NP_032548.2

Status: VALIDATED

Source sequence(s)

AK036491

Consensus CDS

CCDS23581.1

UniProtKB/Swiss-Prot

P08071, P70690, Q61799, Q8CBA0, Q922P2

UniProtKB/TrEMBL

Q3TP24, Q3UBV2, Q4FJR3

Related

ENSMUSP00000035077.4, ENSMUST00000035077.8

Conserved Domains (4) summary

smart00094
Location:363 → 692

TR_FER; Transferrin

cd13617
Location:361 → 691

PBP2_transferrin_C; The C-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily

cd13618
Location:23 → 349

PBP2_transferrin_N; The N-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily

pfam00405
Location:24 → 351

Transferrin; Transferrin