U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Mrgprd MAS-related GPR, member D [ Mus musculus (house mouse) ]

    Gene ID: 211578, updated on 27-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Mrgprdprovided by MGI
    Official Full Name
    MAS-related GPR, member Dprovided by MGI
    Primary source
    MGI:MGI:3033142
    See related
    Ensembl:ENSMUSG00000051207 AllianceGenome:MGI:3033142
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mgrd; MrgD; TGR7; Gm499
    Summary
    Enables G protein-coupled peptide receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure. Predicted to be active in plasma membrane. Is expressed in genitourinary system; nervous system; and skin. Used to study dilated cardiomyopathy. Orthologous to human MRGPRD (MAS related GPR family member D). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Mrgprd in Genome Data Viewer
    Location:
    7 F5; 7 89.06 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (144868572..144877796)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (145314835..145324059)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene two pore segment channel 2 Neighboring gene VISTA enhancer mm1497 Neighboring gene small integral membrane protein 38 Neighboring gene STARR-seq mESC enhancer starr_20570 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:152429156-152429339 Neighboring gene STARR-positive B cell enhancer ABC_E3765 Neighboring gene STARR-seq mESC enhancer starr_20571 Neighboring gene MAS-related GPR, member F Neighboring gene STARR-seq mESC enhancer starr_20573

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Brown adipose tissue transcriptome unveils an important role of the Beta-alanine/alamandine receptor, MrgD, in metabolism. Cerri GC, et al. J Nutr Biochem, 2023 Apr. PMID 36641071
    2. Mas-related G protein-coupled receptor D participates in inflammatory pain by promoting NF-κB activation through interaction with TAK1 and IKK complex. Lan L, et al. Cell Signal, 2020 Dec. PMID 33080316
    3. Mrgprd enhances excitability in specific populations of cutaneous murine polymodal nociceptors. Rau KK, et al. J Neurosci, 2009 Jul 1. PMID 19571152, Free PMC Article
    4. Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. Cavanaugh DJ, et al. Proc Natl Acad Sci U S A, 2009 Jun 2. PMID 19451647, Free PMC Article
    5. Expression and Function of Mas-Related G Protein-Coupled Receptor D and Its Ligand Alamandine in Retina. Zhu P, et al. Mol Neurobiol, 2020 Jan. PMID 31392515

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Accumulation of beta-aminoisobutyric acid mediates hyperalgesia in ovariectomized mice through Mas-related G protein-coupled receptor D signaling.
      Title: Accumulation of β-aminoisobutyric acid mediates hyperalgesia in ovariectomized mice through Mas-related G protein-coupled receptor D signaling.
    2. The Mas-related G protein-coupled receptor d (Mrgprd) mediates pain hypersensitivity in painful diabetic neuropathy.
      Title: The Mas-related G protein-coupled receptor d (Mrgprd) mediates pain hypersensitivity in painful diabetic neuropathy.
    3. Brown adipose tissue transcriptome unveils an important role of the Beta-alanine/alamandine receptor, MrgD, in metabolism.
      Title: Brown adipose tissue transcriptome unveils an important role of the Beta-alanine/alamandine receptor, MrgD, in metabolism.
    4. Impact of genetic deletion of MrgD or Mas receptors in depressive-like behaviour in mice.
      Title: Impact of genetic deletion of MrgD or Mas receptors in depressive-like behaviour in mice.
    5. Identification of MrgprD expression in mouse enteric neurons.
      Title: Identification of MrgprD expression in mouse enteric neurons.
    6. Mas-related G protein-coupled receptor D participates in inflammatory pain by promoting NF-kappaB activation through interaction with TAK1 and IKK complex.
      Title: Mas-related G protein-coupled receptor D participates in inflammatory pain by promoting NF-κB activation through interaction with TAK1 and IKK complex.
    7. Expression and Function of Mas-Related G Protein-Coupled Receptor D and Its Ligand Alamandine in Retina.
      Title: Expression and Function of Mas-Related G Protein-Coupled Receptor D and Its Ligand Alamandine in Retina.
    8. This study shows, for the first time, the expression and localization of MrgprD in the intestinal tract and in macrophages and T lymphocytes, indicating the potential roles of MrgprD in intestinal mobility and immunity.
      Title: Expression and localization of MrgprD in mouse intestinal tract.
    9. MrgD-deficient mice presented a pronounced dilated cardiomyopathy with a marked decrease in systolic function.
      Title: Genetic deletion of the alamandine receptor MRGD leads to dilated cardiomyopathy in mice.
    10. MrgprD is essential in cold allodynia in CCI-induced neuropathic pain through the PKA-TRP-A1 pathway
      Title: Facilitation of MrgprD by TRP-A1 promotes neuropathic pain.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (9)  1 citation

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    mas-related G-protein coupled receptor member D
    Names
    G protein-coupled receptor MrgD
    G-protein coupled receptor TGR7
    Mas-related G protein-coupled receptor d
    beta-alanine receptor

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_203490.4 → NP_987075.1  mas-related G-protein coupled receptor member D

      See identical proteins and their annotated locations for NP_987075.1

      Status: VALIDATED

      Source sequence(s)
      AC132081, AC225443
      Consensus CDS
      CCDS22057.1
      UniProtKB/Swiss-Prot
      Q91ZB8
      UniProtKB/TrEMBL
      Q5UCB4
      Related
      ENSMUSP00000063021.7, ENSMUST00000062163.8
      Conserved Domains (2) summary
      pfam00001
      Location:43 → 278
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:36 → 220
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      144868572..144877796
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZB8.1 GenPept UniProtKB/Swiss-Prot:Q91ZB8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools