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    Cyc1 cytochrome c-1 [ Mus musculus (house mouse) ]

    Gene ID: 66445, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Cyc1provided by MGI
    Official Full Name
    cytochrome c-1provided by MGI
    Primary source
    MGI:MGI:1913695
    See related
    Ensembl:ENSMUSG00000022551 AllianceGenome:MGI:1913695
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cyct1; 2610002H19Rik
    Summary
    Predicted to enable heme binding activity; metal ion binding activity; and ubiquinol-cytochrome-c reductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c and response to glucagon. Located in mitochondrion. Part of respiratory chain complex III. Is active in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; heart; integumental system; limb; and nervous system. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 6. Orthologous to human CYC1 (cytochrome c1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 596.3), duodenum adult (RPKM 388.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cyc1 in Genome Data Viewer
    Location:
    15 D3; 15 35.74 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76227711..76230460)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76343513..76346260)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene GPI anchor attachment protein 1 Neighboring gene ribosomal protein S6, pseudogene 1 Neighboring gene SHANK-associated RH domain interacting protein Neighboring gene MAF1 homolog, negative regulator of RNA polymerase III

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Roles of Neuroglobin Binding to Mitochondrial Complex III Subunit Cytochrome c1 in Oxygen-Glucose Deprivation-Induced Neurotoxicity in Primary Neurons. Yu Z, et al. Mol Neurobiol, 2016 Jul. PMID 26050086
    2. Smac/DIABLO is not released from mitochondria during apoptotic signalling in cells deficient in cytochrome c. Hansen TM, et al. Cell Death Differ, 2006 Jul. PMID 16239929
    3. A Bax/Bak-independent mechanism of cytochrome c release. Mizuta T, et al. J Biol Chem, 2007 Jun 1. PMID 17409097
    4. Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cipolat S, et al. Cell, 2006 Jul 14. PMID 16839884
    5. Identification of neuroglobin-interacting proteins using yeast two-hybrid screening. Yu Z, et al. Neuroscience, 2012 Jan 3. PMID 22079573, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ngb can bind to mitochondrial complex III subunit Cyc1, leading to suppression of oxygen-glucose deprivation -mediated complex III activity.
      Title: Roles of Neuroglobin Binding to Mitochondrial Complex III Subunit Cytochrome c1 in Oxygen-Glucose Deprivation-Induced Neurotoxicity in Primary Neurons.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquinol-cytochrome-c reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular respiration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to glucagon IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to glucagon ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex III ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c1, heme protein, mitochondrial
    Names
    complex III subunit 4
    complex III subunit IV
    cytochrome b-c1 complex subunit 4
    ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit
    NP_079843.1
    XP_030104554.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025567.3 → NP_079843.1  cytochrome c1, heme protein, mitochondrial

      See identical proteins and their annotated locations for NP_079843.1

      Status: VALIDATED

      Source sequence(s)
      AA738621, AK011288, AW121892
      Consensus CDS
      CCDS27567.1
      UniProtKB/Swiss-Prot
      Q3TDC5, Q3UAN2, Q63ZW4, Q9D0M3, Q9DCG0
      Related
      ENSMUSP00000023210.7, ENSMUST00000023210.8
      Conserved Domains (1) summary
      pfam02167
      Location:96 → 314
      Cytochrom_C1; Cytochrome C1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76227711..76230460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248694.2 → XP_030104554.1  cytochrome c1, heme protein, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam02167
      Location:37 → 253
      Cytochrom_C1; Cytochrome C1 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D0M3.1 GenPept UniProtKB/Swiss-Prot:Q9D0M3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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