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    Tnfsf15 tumor necrosis factor (ligand) superfamily, member 15 [ Mus musculus (house mouse) ]

    Gene ID: 326623, updated on 23-Dec-2024

    Summary

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    Official Symbol
    Tnfsf15provided by MGI
    Official Full Name
    tumor necrosis factor (ligand) superfamily, member 15provided by MGI
    Primary source
    MGI:MGI:2180140
    See related
    Ensembl:ENSMUSG00000050395 AllianceGenome:MGI:2180140
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tl1; Tl1a; Vegi; Tnlg1b
    Summary
    Predicted to enable cytokine activity and death receptor binding activity. Predicted to be involved in cell surface receptor signaling pathway; positive regulation of cytokine production; and positive regulation of signal transduction. Predicted to act upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Used to study inflammatory bowel disease 16. Orthologous to human TNFSF15 (TNF superfamily member 15). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Tnfsf15 in Genome Data Viewer
    Location:
    4 C1; 4 34.06 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (63642837..63663296, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (63724600..63745059, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10446 Neighboring gene predicted gene 11482 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 42294 Neighboring gene STARR-seq mESC enhancer starr_10447 Neighboring gene tumor necrosis factor (ligand) superfamily, member 8 Neighboring gene ribosomal protein L17, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The endothelial cell-produced antiangiogenic cytokine vascular endothelial growth inhibitor induces dendritic cell maturation. Tian F, et al. J Immunol, 2007 Sep 15. PMID 17785811
    2. Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome. Jacob N, et al. Mucosal Immunol, 2018 Sep. PMID 29988118, Free PMC Article
    3. Overexpression of Tumor Necrosis Factor-Like Ligand 1 A in Myeloid Cells Aggravates Liver Fibrosis in Mice. Guo J, et al. J Immunol Res, 2019. PMID 30906791, Free PMC Article
    4. Effects and Mechanism of Constitutive TL1A Expression on Intestinal Mucosal Barrier in DSS-Induced Colitis. Yang M, et al. Dig Dis Sci, 2019 Jul. PMID 30949903
    5. Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis. Shih DQ, et al. PLoS One, 2011 Jan 11. PMID 21264313, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Necroptosis plays a role in TL1A-induced airway inflammation and barrier damage in asthma.
      Title: Necroptosis plays a role in TL1A-induced airway inflammation and barrier damage in asthma.
    2. TL1A is an epithelial alarmin that cooperates with IL-33 for initiation of allergic airway inflammation.
      Title: TL1A is an epithelial alarmin that cooperates with IL-33 for initiation of allergic airway inflammation.
    3. Roles of tumor necrosis factor-like ligand 1A in gammadeltaT-cell activation and psoriasis pathogenesis.
      Title: Roles of tumor necrosis factor-like ligand 1A in γδT-cell activation and psoriasis pathogenesis.
    4. TNFSF15 facilitates the differentiation of CD11b[+] myeloid cells into vascular pericytes in tumors.
      Title: TNFSF15 facilitates the differentiation of CD11b(+) myeloid cells into vascular pericytes in tumors.
    5. TL1A promotes the postoperative cognitive dysfunction in mice through NLRP3-mediated A1 differentiation of astrocytes.
      Title: TL1A promotes the postoperative cognitive dysfunction in mice through NLRP3-mediated A1 differentiation of astrocytes.
    6. Identification of a novel role for TL1A/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption.
      Title: Identification of a novel role for TL1A/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption.
    7. TNFSF15 facilitates differentiation and polarization of macrophages toward M1 phenotype to inhibit tumor growth.
      Title: TNFSF15 facilitates differentiation and polarization of macrophages toward M1 phenotype to inhibit tumor growth.
    8. A Protective Role of Tumor Necrosis Factor Superfamily-15 in Intracerebral Hemorrhage-Induced Secondary Brain Injury.
      Title: A Protective Role of Tumor Necrosis Factor Superfamily-15 in Intracerebral Hemorrhage-Induced Secondary Brain Injury.
    9. Effect and Mechanism of TL1A Expression on Epithelial-Mesenchymal Transition during Chronic Colitis-Related Intestinal Fibrosis.
      Title: Effect and Mechanism of TL1A Expression on Epithelial-Mesenchymal Transition during Chronic Colitis-Related Intestinal Fibrosis.
    10. Tumor necrosis factor ligand-related molecule 1A maintains blood-retinal barrier via modulating SHP-1-Src-VE-cadherin signaling in diabetic retinopathy.
      Title: Tumor necrosis factor ligand-related molecule 1A maintains blood-retinal barrier via modulating SHP-1-Src-VE-cadherin signaling in diabetic retinopathy.
    Submit: New GeneRIF Correction See all GeneRIFs (44)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables death receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in positive regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tumor necrosis factor ligand superfamily member 15
    Names
    TNF ligand-related molecule 1
    bM20K13.3 (tumor necrosis factor (ligand) superfamily, member 15)
    tumor necrosis factor ligand 1b
    vascular endothelial cell growth inhibitor
    vascular endothelial growth inhibitor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177371.4 → NP_796345.4  tumor necrosis factor ligand superfamily member 15

      Status: VALIDATED

      Source sequence(s)
      AL691468
      Consensus CDS
      CCDS18263.2
      UniProtKB/Swiss-Prot
      Q5UBV8, Q8K3Y8
      UniProtKB/TrEMBL
      B2RR33, E9PVT2, F6VXB8
      Related
      ENSMUSP00000159365.2, ENSMUST00000239480.2
      Conserved Domains (1) summary
      pfam00229
      Location:119 → 252
      TNF; TNF(tumor Necrosis Factor) family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      63642837..63663296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5UBV8.2 GenPept UniProtKB/Swiss-Prot:Q5UBV8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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