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    Prrg2 proline-rich Gla (G-carboxyglutamic acid) polypeptide 2 [ Mus musculus (house mouse) ]

    Gene ID: 65116, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Prrg2provided by MGI
    Official Full Name
    proline-rich Gla (G-carboxyglutamic acid) polypeptide 2provided by MGI
    Primary source
    MGI:MGI:1929596
    See related
    Ensembl:ENSMUSG00000007837 AllianceGenome:MGI:1929596
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    N4WBP1; 1600014G02Rik; 2510041M06Rik
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in blood coagulation. Predicted to be located in membrane. Predicted to be active in extracellular space and plasma membrane. Orthologous to human PRRG2 (proline rich and Gla domain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 35.9), stomach adult (RPKM 25.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prrg2 in Genome Data Viewer
    Location:
    7 B3; 7 29.1 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44703008..44711828, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45053584..45062672, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E130 Neighboring gene STARR-positive B cell enhancer ABC_E871 Neighboring gene related RAS viral (r-ras) oncogene Neighboring gene proline rich 12 Neighboring gene STARR-positive B cell enhancer ABC_E6541 Neighboring gene STARR-positive B cell enhancer ABC_E2235 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52317657-52317840 Neighboring gene nitric oxide synthase interacting protein Neighboring gene reticulocalbin 3, EF-hand calcium binding domain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4. Jolliffe CN, et al. Biochem J, 2000 Nov 1. PMID 11042109, Free PMC Article
    2. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane gamma-carboxyglutamic acid protein 2
    Names
    NEDD4 WW domain-binding protein 1
    proline-rich Gla protein 2
    proline-rich gamma-carboxyglutamic acid protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419032.1 → NP_001405961.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC126256
      UniProtKB/TrEMBL
      A0A1B0GS92
      Related
      ENSMUSP00000147844.2, ENSMUST00000210493.2

    2. NM_001419033.1 → NP_001405962.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC126256
      UniProtKB/Swiss-Prot
      Q8R182, Q9EQI2
      UniProtKB/TrEMBL
      A0A1B0GSK7
      Related
      ENSMUSP00000148014.2, ENSMUST00000210690.2

    3. NM_001419034.1 → NP_001405963.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC126256
      UniProtKB/Swiss-Prot
      Q8R182, Q9EQI2
      UniProtKB/TrEMBL
      A0A1B0GSK7
      Related
      ENSMUSP00000147977.2, ENSMUST00000211014.2

    4. NM_001419035.1 → NP_001405964.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC126256
      UniProtKB/TrEMBL
      A0A1B0GS92

    5. NM_001419036.1 → NP_001405965.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC126256
      UniProtKB/TrEMBL
      A0A1B0GS92

    6. NM_022999.2 → NP_075375.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_075375.1

      Status: VALIDATED

      Source sequence(s)
      AC126256
      Consensus CDS
      CCDS21227.1
      UniProtKB/Swiss-Prot
      Q8R182, Q9EQI2
      UniProtKB/TrEMBL
      A0A1B0GSK7
      Related
      ENSMUSP00000007981.4, ENSMUST00000007981.9
      Conserved Domains (1) summary
      smart00069
      Location:33 → 97
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    RNA

    1. NR_185003.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC126256

    2. NR_185004.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC126256

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44703008..44711828 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R182.1 GenPept UniProtKB/Swiss-Prot:Q8R182

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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