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    Armh4 armadillo-like helical domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 67419, updated on 24-Dec-2024

    Summary

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    Official Symbol
    Armh4provided by MGI
    Official Full Name
    armadillo-like helical domain containing 4provided by MGI
    Primary source
    MGI:MGI:1914669
    See related
    Ensembl:ENSMUSG00000036242 AllianceGenome:MGI:1914669
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3632451O06Rik
    Summary
    Enables TORC2 complex binding activity. Involved in regulation of TORC2 signaling. Predicted to be located in membrane. Is expressed in several structures, including embryo mesenchyme; facial prominence; heart; nervous system; and vibrissa. Orthologous to human ARMH4 (armadillo like helical domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 12.4), bladder adult (RPKM 10.1) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Armh4 in Genome Data Viewer
    Location:
    14 C1; 14 25.78 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (49919017..50020843, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (49681560..49783480, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member F4 Neighboring gene predicted gene, 52146 Neighboring gene STARR-seq mESC enhancer starr_36633 Neighboring gene predicted gene, 22116 Neighboring gene STARR-seq mESC enhancer starr_36634 Neighboring gene STARR-seq mESC enhancer starr_36635 Neighboring gene 60S ribosomal protein L24 pseudogene Neighboring gene predicted gene, 36146 Neighboring gene STARR-seq mESC enhancer starr_36636 Neighboring gene STARR-seq mESC enhancer starr_36637 Neighboring gene STARR-seq mESC enhancer starr_36638 Neighboring gene STARR-seq mESC enhancer starr_36639 Neighboring gene STARR-seq mESC enhancer starr_36640 Neighboring gene predicted gene 8417 Neighboring gene STARR-seq mESC enhancer starr_36642 Neighboring gene olfactory receptor family 4 subfamily N member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Single Cell Multimodal Analyses Reveal Epigenomic and Transcriptomic Basis for Birth Defects in Maternal Diabetes. Nishino T, et al. Nat Cardiovasc Res, 2023 Dec. PMID 39183978, Free PMC Article
    2. The developmental Wnt signaling pathway effector β-catenin/TCF mediates hepatic functions of the sex hormone estradiol in regulating lipid metabolism. Tian L, et al. PLoS Biol, 2019 Oct. PMID 31589598, Free PMC Article
    3. Armadillo-like helical domain containing-4 is dynamically expressed in both the first and second heart fields. Conway SJ, et al. Gene Expr Patterns, 2019 Dec. PMID 31655130, Free PMC Article
    4. Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors. Lee D, et al. Stem Cell Reports, 2014 Nov 11. PMID 25418727, Free PMC Article
    5. Mouse ES cell-derived cardiac precursor cells are multipotent and facilitate identification of novel cardiac genes. Christoforou N, et al. J Clin Invest, 2008 Mar. PMID 18246200, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables TORC2 complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of TORC2 signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    armadillo-like helical domain-containing protein 4
    Names
    uncharacterized protein C14orf37 homolog
    upstream of mTORC2 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358244.1 → NP_001345173.1  armadillo-like helical domain-containing protein 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC140393, AK014402, AK028180
      Consensus CDS
      CCDS88649.1
      UniProtKB/TrEMBL
      D3Z566
      Related
      ENSMUSP00000113609.2, ENSMUST00000118129.2
      Conserved Domains (1) summary
      pfam15767
      Location:48 → 606
      DUF4696; Domain of unknown function (DUF4696)

    2. NM_026142.5 → NP_080418.2  armadillo-like helical domain-containing protein 4 precursor

      See identical proteins and their annotated locations for NP_080418.2

      Status: VALIDATED

      Source sequence(s)
      AC140393, AK014402, AK032093
      Consensus CDS
      CCDS36903.1
      UniProtKB/Swiss-Prot
      Q8BFQ7, Q8BT18, Q8R1Q5, Q9D6C5
      Related
      ENSMUSP00000036220.7, ENSMUST00000036972.14
      Conserved Domains (1) summary
      pfam15767
      Location:48 → 606
      DUF4696; Domain of unknown function (DUF4696)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      49919017..50020843 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519452.5 → XP_006519515.1  armadillo-like helical domain-containing protein 4 isoform X1

      Conserved Domains (1) summary
      pfam15767
      Location:48 → 606
      DUF4696; Domain of unknown function (DUF4696)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BT18.2 GenPept UniProtKB/Swiss-Prot:Q8BT18

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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