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    Pnpo pyridoxine 5'-phosphate oxidase [ Mus musculus (house mouse) ]

    Gene ID: 103711, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pnpoprovided by MGI
    Official Full Name
    pyridoxine 5'-phosphate oxidaseprovided by MGI
    Primary source
    MGI:MGI:2144151
    See related
    Ensembl:ENSMUSG00000018659 AllianceGenome:MGI:2144151
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables pyridoxamine phosphate oxidase activity. Involved in pyridoxal phosphate metabolic process and pyridoxamine metabolic process. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in pyridoxamine 5'-phosphate oxidase deficiency. Orthologous to human PNPO (pyridoxamine 5'-phosphate oxidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver E14.5 (RPKM 227.8), liver E14 (RPKM 217.6) and 14 other tissues See more
    Orthologs
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    Genomic context

    See Pnpo in Genome Data Viewer
    Location:
    11 D; 11 60.17 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96828642..96834845, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96937816..96944019, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CDK5 regulatory subunit associated protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E202 Neighboring gene predicted gene 11525 Neighboring gene proline rich 15-like Neighboring gene STARR-seq mESC enhancer starr_30572 Neighboring gene RIKEN cDNA D030028A08 gene Neighboring gene STARR-positive B cell enhancer ABC_E2367 Neighboring gene Sp2 transcription factor Neighboring gene STARR-positive B cell enhancer ABC_E11488 Neighboring gene STARR-positive B cell enhancer ABC_E20 Neighboring gene STARR-seq mESC enhancer starr_30576 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:96849306-96849459 Neighboring gene predicted gene, 51916

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables FMN binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables pyridoxal phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyridoxamine phosphate oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pyridoxamine phosphate oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pyridoxamine phosphate oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables pyridoxamine phosphate oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in pyridoxal phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in pyridoxal phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pyridoxal phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyridoxal phosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pyridoxamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pyridoxine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    pyridoxine-5'-phosphate oxidase
    Names
    pyridoxamine-phosphate oxidase
    NP_598782.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134021.2NP_598782.1  pyridoxine-5'-phosphate oxidase

      Status: VALIDATED

      Source sequence(s)
      AI464320, AK164667, AL596384, CK625276
      Consensus CDS
      CCDS25308.1
      UniProtKB/Swiss-Prot
      Q3TP70, Q3U445, Q3U4X1, Q91XF0
      Related
      ENSMUSP00000018803.6, ENSMUST00000018803.12
      Conserved Domains (3) summary
      TIGR00558
      Location:57261
      pdxH; pyridoxamine-phosphate oxidase
      pfam01243
      Location:75153
      Pyridox_oxidase; Pyridoxamine 5'-phosphate oxidase
      pfam10590
      Location:206261
      PNPOx_C; Pyridoxine 5'-phosphate oxidase C-terminal dimerization region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      96828642..96834845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)