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    KRT7 keratin 7 [ Homo sapiens (human) ]

    Gene ID: 3855, updated on 10-Dec-2024

    Summary

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    Official Symbol
    KRT7provided by HGNC
    Official Full Name
    keratin 7provided by HGNC
    Primary source
    HGNC:HGNC:6445
    See related
    Ensembl:ENSG00000135480 MIM:148059; AllianceGenome:HGNC:6445
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    K7; CK7; SCL; K2C7
    Summary
    The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in thyroid (RPKM 146.2), placenta (RPKM 75.4) and 5 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KRT7 in Genome Data Viewer
    Location:
    12q13.13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (52233243..52255853)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (52196307..52215830)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (52627027..52642705)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratin 80 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:52577352-52578177 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52591988-52592488 Neighboring gene long intergenic non-protein coding RNA 2874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52607231-52607792 Neighboring gene long intergenic non-protein coding RNA 592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6396 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:52627613-52628588 Neighboring gene thiol methyltransferase 1A pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52636625-52637600 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6397 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6398 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:52643584-52644190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52645720-52646220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52646221-52646721 Neighboring gene KRT7 antisense RNA 1 Neighboring gene keratin 87, pseudogene Neighboring gene keratin 88, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:52673861-52675060 Neighboring gene keratin 86 Neighboring gene keratin 81

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CK7 Immunohistochemistry as a Predictor of CIN1 Progression: A Retrospective Study of Patients From the Quadrivalent HPV Vaccine Trials. Mills AM, et al. Am J Surg Pathol, 2017 Feb. PMID 27680604
    2. Prognostic value of cytokeratin-7 mRNA expression in peripheral whole blood of advanced lung adenocarcinoma patients. Koren A, et al. Cell Oncol (Dordr), 2015 Oct. PMID 26306784
    3. Cytokeratin 7 is a predictive marker for survival in patients with esophageal squamous cell carcinoma. Oue N, et al. Ann Surg Oncol, 2012 Jun. PMID 22203179
    4. Predictive Value of Cytokeratin 7 Immunohistochemistry in Cervical Low-grade Squamous Intraepithelial Lesion as a Marker for Risk of Progression to a High-grade Lesion. Paquette C, et al. Am J Surg Pathol, 2016 Feb. PMID 26551618
    5. Effects of sarcolectin (SCL) on human peripheral blood mononuclear cells. M'bika-Binzangi JP, et al. Biochimie, 2006 Jun. PMID 16483709

    See all (179) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of cytokeratin 7/20 and Ki67 in Helicobacter pylori-associated gastritis and intestinal metaplasia.
      Title: Expression of cytokeratin 7/20 and Ki67 in Helicobacter pylori-associated gastritis and intestinal metaplasia.
    2. Role of the KRT7 Biomarker in Immune Infiltration and Paclitaxel Resistance in Ovarian.
      Title: Role of the KRT7 Biomarker in Immune Infiltration and Paclitaxel Resistance in Ovarian.
    3. Colonocyte keratin 7 is expressed de novo in inflammatory bowel diseases and associated with pathological changes and drug-resistance.
      Title: Colonocyte keratin 7 is expressed de novo in inflammatory bowel diseases and associated with pathological changes and drug-resistance.
    4. Aberrant cytokeratin 7 expression by hepatocytes can predict the ductopenia grade in primary biliary cholangitis.
      Title: Aberrant cytokeratin 7 expression by hepatocytes can predict the ductopenia grade in primary biliary cholangitis.
    5. A triple-classification for differentiating renal oncocytoma from renal cell carcinoma subtypes and CK7 expression evaluation: a radiomics analysis.
      Title: A triple-classification for differentiating renal oncocytoma from renal cell carcinoma subtypes and CK7 expression evaluation: a radiomics analysis.
    6. Construction of a novel model based on cell-in-cell-related genes and validation of KRT7 as a biomarker for predicting survival and immune microenvironment in pancreatic cancer.
      Title: Construction of a novel model based on cell-in-cell-related genes and validation of KRT7 as a biomarker for predicting survival and immune microenvironment in pancreatic cancer.
    7. Expression Level of Keratin 7 in Epithelial Ovarian Cancer and Malignant Metastasis of Benign Epithelial Ovarian Tumors.
      Title: Expression Level of Keratin 7 in Epithelial Ovarian Cancer and Malignant Metastasis of Benign Epithelial Ovarian Tumors.
    8. Cytokeratin 7 and cytokeratin 20 expression in cancer: A tissue microarray study on 15,424 cancers.
      Title: Cytokeratin 7 and cytokeratin 20 expression in cancer: A tissue microarray study on 15,424 cancers.
    9. Oncocytic renal neoplasms with diffuse keratin 7 immunohistochemistry harbor frequent alterations in the mammalian target of rapamycin pathway.
      Title: Oncocytic renal neoplasms with diffuse keratin 7 immunohistochemistry harbor frequent alterations in the mammalian target of rapamycin pathway.
    10. Biomarkers CDX2, CK20, CK7 in Schoolchildren with Gastritis in the Realization of Familial Predisposition of Stomach Cancer.
      Title: Biomarkers CDX2, CK20, CK7 in Schoolchildren with Gastritis in the Realization of Familial Predisposition of Stomach Cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (112)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC3625, MGC129731

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of skin epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratinization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in intermediate filament NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in intermediate filament cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    keratin, type II cytoskeletal 7
    Names
    CK-7
    cytokeratin 7
    keratin 7, type II
    keratin, 55K type II cytoskeletal
    keratin, simple epithelial type I, K7
    sarcolectin
    type II mesothelial keratin K7
    type-II keratin Kb7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012296.1 RefSeqGene

      Range
      5074..20752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005556.4 → NP_005547.3  keratin, type II cytoskeletal 7

      See identical proteins and their annotated locations for NP_005547.3

      Status: REVIEWED

      Source sequence(s)
      AC021066, BC002700, BE740515, BE744321
      Consensus CDS
      CCDS8822.1
      UniProtKB/Swiss-Prot
      P08729, Q92676, Q9BUD8, Q9Y3R7
      UniProtKB/TrEMBL
      B3KY79
      Related
      ENSP00000329243.5, ENST00000331817.6
      Conserved Domains (3) summary
      pfam00038
      Location:90 → 402
      Filament; Intermediate filament protein
      pfam13312
      Location:15 → 95
      DUF4081; Domain of unknown function (DUF4081)
      pfam16208
      Location:1 → 87
      Keratin_2_head; Keratin type II head

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      52233243..52255853
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011538325.3 → XP_011536627.1  keratin, type II cytoskeletal 7 isoform X1

      UniProtKB/TrEMBL
      B3KY79
      Conserved Domains (4) summary
      pfam00038
      Location:90 → 402
      Filament; Intermediate filament protein
      pfam13312
      Location:15 → 95
      DUF4081; Domain of unknown function (DUF4081)
      pfam16208
      Location:1 → 87
      Keratin_2_head; Keratin type II head
      pfam16888
      Location:142 → 249
      DUF5082; Domain of unknown function (DUF5082)

    2. XM_047428827.1 → XP_047284783.1  keratin, type II cytoskeletal 7 isoform X2

    3. XM_017019294.2 → XP_016874783.1  keratin, type II cytoskeletal 7 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      52196307..52215830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372019.1 → XP_054227994.1  keratin, type II cytoskeletal 7 isoform X6

      UniProtKB/TrEMBL
      B3KY79

    2. XM_054372018.1 → XP_054227993.1  keratin, type II cytoskeletal 7 isoform X5

    3. XM_054372020.1 → XP_054227995.1  keratin, type II cytoskeletal 7 isoform X1

      UniProtKB/TrEMBL
      B3KY79

    4. XM_054372017.1 → XP_054227992.1  keratin, type II cytoskeletal 7 isoform X4

      UniProtKB/TrEMBL
      B3KY79

    5. XM_054372021.1 → XP_054227996.1  keratin, type II cytoskeletal 7 isoform X7

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08729.5 GenPept UniProtKB/Swiss-Prot:P08729

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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