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    MYADM myeloid associated differentiation marker [ Homo sapiens (human) ]

    Gene ID: 91663, updated on 27-Nov-2024

    Summary

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    Official Symbol
    MYADMprovided by HGNC
    Official Full Name
    myeloid associated differentiation markerprovided by HGNC
    Primary source
    HGNC:HGNC:7544
    See related
    Ensembl:ENSG00000179820 MIM:609959; AllianceGenome:HGNC:7544
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SB135
    Summary
    Involved in several processes, including negative regulation of actin filament polymerization; negative regulation of heterotypic cell-cell adhesion; and positive regulation of substrate adhesion-dependent cell spreading. Located in several cellular components, including cortical actin cytoskeleton; membrane raft; and ruffle. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung (RPKM 50.4), gall bladder (RPKM 50.0) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
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    Genomic context

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    See MYADM in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (53865628..53876435)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (56945407..56956143)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54368882..54379689)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54295400-54295900 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54295901-54296401 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54300296-54300796 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54301378-54301878 Neighboring gene microRNA 373 Neighboring gene NLR family pyrin domain containing 12 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54332809-54333578 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54334349-54335116 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54335887-54336656 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54337427-54338194 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:54339735-54340504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54342811-54343580 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54343581-54344348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54361270-54361770 Neighboring gene MYADM antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54369942-54370917 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54372027-54372940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54372941-54373854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54385903-54386454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54395841-54396380 Neighboring gene protein kinase C gamma Neighboring gene Sharpr-MPRA regulatory region 4174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54410617-54411158 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 7 Neighboring gene MPRA-validated peak3551 silencer

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MYADM binds human parechovirus 1 and is essential for viral entry. Qiao W, et al. Nat Commun, 2024 Apr 24. PMID 38658526, Free PMC Article
    2. Cloning of human myeloid-associated differentiation marker (MYADM) gene whose expression was up-regulated in NB4 cells induced by all-trans retinoic acid. Cui W, et al. Mol Biol Rep, 2001. PMID 12075932
    3. Membrane protein hMYADM preferentially expressed in myeloid cells is up-regulated during differentiation of stem cells and myeloid leukemia cells. Wang Q, et al. Life Sci, 2007 Jan 9. PMID 17097684
    4. Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry. Watanabe K, et al. Nat Commun, 2023 Mar 31. PMID 37002207, Free PMC Article
    5. Myeloid-associated differentiation marker is a novel SP-A-associated transmembrane protein whose expression on airway epithelial cells correlates with asthma severity. Dy ABC, et al. Sci Rep, 2021 Dec 3. PMID 34862427, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Smooth Muscle Ythdf2 Abrogation Ameliorates Pulmonary Vascular Remodeling by Regulating Myadm Transcript Stability.
      Title: Smooth Muscle Ythdf2 Abrogation Ameliorates Pulmonary Vascular Remodeling by Regulating Myadm Transcript Stability.
    2. MYADM binds human parechovirus 1 and is essential for viral entry.
      Title: MYADM binds human parechovirus 1 and is essential for viral entry.
    3. Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry.
      Title: Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry.
    4. Myeloid-associated differentiation marker is a novel SP-A-associated transmembrane protein whose expression on airway epithelial cells correlates with asthma severity.
      Title: Myeloid-associated differentiation marker is a novel SP-A-associated transmembrane protein whose expression on airway epithelial cells correlates with asthma severity.
    5. miR-182-3p/Myadm contribute to pulmonary artery hypertension vascular remodeling via a KLF4/p21-dependent mechanism.
      Title: miR-182-3p/Myadm contribute to pulmonary artery hypertension vascular remodeling via a KLF4/p21-dependent mechanism.
    6. MYADM gene expression is significantly associated with long-term changes in Blood Pressure, providing a link between gene expression and Blood Pressure.
      Title: Transcriptome-Wide Analysis Identifies Novel Associations With Blood Pressure.
    7. MYADM controls endothelial barrier function through ERM-dependent regulation of ICAM-1 expression.
      Title: MYADM controls endothelial barrier function through ERM-dependent regulation of ICAM-1 expression.
    8. Myeloid-associated differentiation marker (MYADM) regulates Rac1 targeting to ordered membranes required for cell spreading and migration.
      Title: MYADM regulates Rac1 targeting to ordered membranes required for cell spreading and migration.
    9. Cloning and characterization of human MYADM gene whose expression was up-regulated in NB4 cells induced by all-trans retinoic acid.
      Title: Cloning of human myeloid-associated differentiation marker (MYADM) gene whose expression was up-regulated in NB4 cells induced by all-trans retinoic acid.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • AC008440.10

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in cell-cell junction maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of endothelial barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in membrane raft organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of heterotypic cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of heterotypic cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane raft IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in regulation of cell-substrate adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cortical actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myeloid-associated differentiation marker
    Names
    myeloid upregulated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020818.2 → NP_001018654.1  myeloid-associated differentiation marker

      See identical proteins and their annotated locations for NP_001018654.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
      Source sequence(s)
      AC008440, AF087882, HY124929
      Consensus CDS
      CCDS12866.1
      UniProtKB/Swiss-Prot
      B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
      UniProtKB/TrEMBL
      B4DG42, E9PBN6
      Related
      ENSP00000375648.2, ENST00000391768.2
      Conserved Domains (1) summary
      pfam01284
      Location:168 → 312
      MARVEL; Membrane-associating domain

    2. NM_001020819.3 → NP_001018655.1  myeloid-associated differentiation marker

      See identical proteins and their annotated locations for NP_001018655.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
      Source sequence(s)
      AC008440, AF087882, DA027466
      Consensus CDS
      CCDS12866.1
      UniProtKB/Swiss-Prot
      B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
      UniProtKB/TrEMBL
      B4DG42, E9PBN6
      Related
      ENSP00000375651.1, ENST00000391771.1
      Conserved Domains (1) summary
      pfam01284
      Location:168 → 312
      MARVEL; Membrane-associating domain

    3. NM_001020820.3 → NP_001018656.1  myeloid-associated differentiation marker

      See identical proteins and their annotated locations for NP_001018656.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
      Source sequence(s)
      AC008440, AF087882, BX393859, DC379591
      Consensus CDS
      CCDS12866.1
      UniProtKB/Swiss-Prot
      B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
      UniProtKB/TrEMBL
      B4DG42, E9PBN6
      Related
      ENSP00000398269.2, ENST00000421337.6
      Conserved Domains (1) summary
      pfam01284
      Location:168 → 312
      MARVEL; Membrane-associating domain

    4. NM_001020821.2 → NP_001018657.1  myeloid-associated differentiation marker

      See identical proteins and their annotated locations for NP_001018657.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
      Source sequence(s)
      AC008440, AF087882, HY124929
      Consensus CDS
      CCDS12866.1
      UniProtKB/Swiss-Prot
      B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
      UniProtKB/TrEMBL
      B4DG42, E9PBN6
      Related
      ENSP00000375649.2, ENST00000391769.3
      Conserved Domains (1) summary
      pfam01284
      Location:168 → 312
      MARVEL; Membrane-associating domain

    5. NM_001290188.2 → NP_001277117.1  myeloid-associated differentiation marker

      See identical proteins and their annotated locations for NP_001277117.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
      Source sequence(s)
      AC008440, AF087882, DC379591
      Consensus CDS
      CCDS12866.1
      UniProtKB/Swiss-Prot
      B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
      UniProtKB/TrEMBL
      B4DG42, E9PBN6
      Conserved Domains (1) summary
      pfam01284
      Location:168 → 312
      MARVEL; Membrane-associating domain

    6. NM_001290189.1 → NP_001277118.1  myeloid-associated differentiation marker

      See identical proteins and their annotated locations for NP_001277118.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) represents the longest transcript. All twelve variants encode the same protein.
      Source sequence(s)
      AC008440, AF087882, DB448983, HY124929
      Consensus CDS
      CCDS12866.1
      UniProtKB/Swiss-Prot
      B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
      UniProtKB/TrEMBL
      B4DG42, E9PBN6
      Conserved Domains (1) summary
      pfam01284
      Location:168 → 312
      MARVEL; Membrane-associating domain

    7. NM_001290190.2 → NP_001277119.1  myeloid-associated differentiation marker

      See identical proteins and their annotated locations for NP_001277119.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
      Source sequence(s)
      AC008440, AF087882, DA677314
      Consensus CDS
      CCDS12866.1
      UniProtKB/Swiss-Prot
      B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
      UniProtKB/TrEMBL
      B4DG42, E9PBN6
      Conserved Domains (1) summary
      pfam01284
      Location:168 → 312
      MARVEL; Membrane-associating domain

    8. NM_001290191.2 → NP_001277120.1  myeloid-associated differentiation marker

      See identical proteins and their annotated locations for NP_001277120.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
      Source sequence(s)
      AC008440, AF087882, DA472260
      Consensus CDS
      CCDS12866.1
      UniProtKB/Swiss-Prot
      B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
      UniProtKB/TrEMBL
      B4DG42, E9PBN6
      Conserved Domains (1) summary
      pfam01284
      Location:168 → 312
      MARVEL; Membrane-associating domain

    9. NM_001290192.2 → NP_001277121.1  myeloid-associated differentiation marker

      See identical proteins and their annotated locations for NP_001277121.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
      Source sequence(s)
      AC008440, AF087882, BQ716724, DA948116
      Consensus CDS
      CCDS12866.1
      UniProtKB/Swiss-Prot
      B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
      UniProtKB/TrEMBL
      B4DG42, E9PBN6
      Conserved Domains (1) summary
      pfam01284
      Location:168 → 312
      MARVEL; Membrane-associating domain

    10. NM_001290193.2 → NP_001277122.1  myeloid-associated differentiation marker

      See identical proteins and their annotated locations for NP_001277122.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
      Source sequence(s)
      AC008440, AF087882, BQ430033
      Consensus CDS
      CCDS12866.1
      UniProtKB/Swiss-Prot
      B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
      UniProtKB/TrEMBL
      B4DG42, E9PBN6
      Conserved Domains (1) summary
      pfam01284
      Location:168 → 312
      MARVEL; Membrane-associating domain

    11. NM_001290194.2 → NP_001277123.1  myeloid-associated differentiation marker

      See identical proteins and their annotated locations for NP_001277123.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
      Source sequence(s)
      AC008440, AF087882, AL524210, DA948116
      Consensus CDS
      CCDS12866.1
      UniProtKB/Swiss-Prot
      B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
      UniProtKB/TrEMBL
      B4DG42, E9PBN6
      Related
      ENSP00000416919.1, ENST00000439000.5
      Conserved Domains (1) summary
      pfam01284
      Location:168 → 312
      MARVEL; Membrane-associating domain

    12. NM_138373.5 → NP_612382.1  myeloid-associated differentiation marker

      See identical proteins and their annotated locations for NP_612382.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 6. All twelve variants encode the same protein.
      Source sequence(s)
      AC008440, AF087882, DA948116
      Consensus CDS
      CCDS12866.1
      UniProtKB/Swiss-Prot
      B2RE58, Q542Z1, Q7Z507, Q8N9R4, Q96CS6, Q96S97, Q96SK9
      UniProtKB/TrEMBL
      B4DG42, E9PBN6
      Related
      ENSP00000375650.4, ENST00000391770.9
      Conserved Domains (1) summary
      pfam01284
      Location:168 → 312
      MARVEL; Membrane-associating domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      53865628..53876435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      56945407..56956143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96S97.2 GenPept UniProtKB/Swiss-Prot:Q96S97

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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