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    RGS6 regulator of G protein signaling 6 [ Homo sapiens (human) ]

    Gene ID: 9628, updated on 10-Dec-2024

    Summary

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    Official Symbol
    RGS6provided by HGNC
    Official Full Name
    regulator of G protein signaling 6provided by HGNC
    Primary source
    HGNC:HGNC:10002
    See related
    Ensembl:ENSG00000182732 MIM:603894; AllianceGenome:HGNC:10002
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GAP; S914; HA117
    Summary
    This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See RGS6 in Genome Data Viewer
    Location:
    14q24.2
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (71867335..72630029)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (66072765..66835660)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (72398888..73033238)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene signal induced proliferation associated 1 like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8675 Neighboring gene uncharacterized LOC145474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8678 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8676 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8677 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8679 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:72072179-72072936 Neighboring gene uncharacterized LOC124903342 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:72220712-72221626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:72225004-72225562 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:72240666-72241865 Neighboring gene Sharpr-MPRA regulatory region 15223 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:72315448-72316027 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:72318891-72319392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8680 Neighboring gene NANOG hESC enhancer GRCh37_chr14:72362092-72362593 Neighboring gene translation initiation factor IF-2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5899 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5900 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5901 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:72410437-72410648 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:72448203-72448816 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:72542545-72543085 Neighboring gene uncharacterized LOC124903343 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:72621633-72622832 Neighboring gene uncharacterized LOC105370559 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:72917516-72918293 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:72923240-72923442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8683 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:72981479-72981979 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8684 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8685 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8686 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:73011529-73012307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8687 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:73066667-73067182 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:73085384-73086583 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:73087954-73088634 Neighboring gene microRNA 7843 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:73109733-73110932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:73118269-73119105 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:73146128-73146975 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:73174572-73175072 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:73208790-73209747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8688 Neighboring gene double PHD fingers 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:73257468-73257968 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:73276522-73277721 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:73318647-73319224 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8689 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:73331388-73331571 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:73342399-73343100 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr14:73343101-73343801 Neighboring gene MPRA-validated peak2194 silencer Neighboring gene Sharpr-MPRA regulatory region 237 Neighboring gene uncharacterized LOC107984711 Neighboring gene uncharacterized LOC124903429

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Decreased RGS6 expression is associated with poor prognosis in pancreatic cancer patients. Jiang N, et al. Int J Clin Exp Pathol, 2014. PMID 25120791, Free PMC Article
    2. Functional study of the novel multidrug resistance gene HA117 and its comparison to multidrug resistance gene 1. Zhao L, et al. J Exp Clin Cancer Res, 2010 Jul 19. PMID 20642825, Free PMC Article
    3. Genome-wide association for smoking cessation success in a trial of precessation nicotine replacement. Uhl GR, et al. Mol Med, 2010 Nov-Dec. PMID 20811658, Free PMC Article
    4. Regulator of G protein signaling 6 (RGS6) induces apoptosis via a mitochondrial-dependent pathway not involving its GTPase-activating protein activity. Maity B, et al. J Biol Chem, 2011 Jan 14. PMID 21041304, Free PMC Article
    5. RGS6 variants are associated with dietary fat intake in Hispanics: the IRAS Family Study. Sibbel SP, et al. Obesity (Silver Spring), 2011 Jul. PMID 21233807, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RGS6 drives cardiomyocyte death following nucleolar stress by suppressing Nucleolin/miRNA-21.
      Title: RGS6 drives cardiomyocyte death following nucleolar stress by suppressing Nucleolin/miRNA-21.
    2. RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition in non-small cell lung cancers via a novel mechanism dependent on its interaction with SMAD4.
      Title: RGS6 suppresses TGF-β-induced epithelial-mesenchymal transition in non-small cell lung cancers via a novel mechanism dependent on its interaction with SMAD4.
    3. Age-dependent nigral dopaminergic neurodegeneration and alpha-synuclein accumulation in RGS6-deficient mice.
      Title: Age-dependent nigral dopaminergic neurodegeneration and α-synuclein accumulation in RGS6-deficient mice.
    4. the results suggest that HA117 regulates the development of drug resistance in CT26 cells in vitro and in vivo.
      Title: The novel gene HA117 promotes in vitro and in vivo drug resistance in mouse colon tumor cells.
    5. study shows that HA117 potentially promotes the stem-like signature of the HL60/ATRA cell line by inhibiting by the ubiquitination and degradation of DNMT1 and by down-regulating the expression of the GGL domain of RGS6
      Title: HA117 endows HL60 cells with a stem-like signature by inhibiting the degradation of DNMT1 via its ability to down-regulate expression of the GGL domain of RGS6.
    6. genetic association studies on a population in Republic of Korea: Data suggest that an SNP in RGS6 (rs2239219) is closely linked to stress-induced abdominal obesity in the population studied.
      Title: Interaction between the RGS6 gene and psychosocial stress on obesity-related traits.
    7. Data support the notion that the Galpha, but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 activation and unveil new roles for RGS and RGS6 in fine-tuning TRPC4 activities.
      Title: Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at Gαi/o.
    8. Our results suggest that HA117 is a strong multidrug resistance gene.
      Title: Multidrug resistance strength of the novel multidrug resistance gene HA117: compared with MRP1.
    9. This suggests that HA117 might be an important resistance gene in pediatric solid tumors.
      Title: Expression of the novel all-trans retinoic acid-related resistance gene HA117 in pediatric solid tumors.
    10. No significant association between SNPs of RGS6 and central adiposity has been found.
      Title: A Common Variant of NGEF Is Associated with Abdominal Visceral Fat in Korean Men.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    EBI GWAS Catalog
    Genome-wide association for smoking cessation success in a trial of precessation nicotine replacement.
    EBI GWAS Catalog
    Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
    EBI GWAS Catalog
    Genome-wide population-based association study of extremely overweight young adults--the GOYA study.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
    EBI GWAS Catalog
    The genetic architecture of economic and political preferences.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ43552, MGC142132, DKFZp313G1241

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    regulator of G-protein signaling 6
    Names
    regulator of G-protein signalling 6

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029236.2 RefSeqGene

      Range
      70096..704197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001204416.3 → NP_001191345.1  regulator of G-protein signaling 6 isoform 1

      See identical proteins and their annotated locations for NP_001191345.1

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      Consensus CDS
      CCDS55924.1
      UniProtKB/TrEMBL
      B7Z2A0
      Related
      ENSP00000451855.1, ENST00000556437.5
      Conserved Domains (4) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:116 → 217
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    2. NM_001204417.3 → NP_001191346.1  regulator of G-protein signaling 6 isoform 3

      See identical proteins and their annotated locations for NP_001191346.1

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      UniProtKB/TrEMBL
      B7Z2A0
      Conserved Domains (3) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    3. NM_001204418.3 → NP_001191347.1  regulator of G-protein signaling 6 isoform 4

      See identical proteins and their annotated locations for NP_001191347.1

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      UniProtKB/TrEMBL
      B2R8R8
      Conserved Domains (3) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    4. NM_001204419.3 → NP_001191348.1  regulator of G-protein signaling 6 isoform 5

      See identical proteins and their annotated locations for NP_001191348.1

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      UniProtKB/TrEMBL
      A0A0A0MRA9
      Related
      ENSP00000341199.7, ENST00000343854.10
      Conserved Domains (3) summary
      cd08737
      Location:291 → 415
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      cl00069
      Location:258 → 285
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    5. NM_001204420.3 → NP_001191349.1  regulator of G-protein signaling 6 isoform 6

      See identical proteins and their annotated locations for NP_001191349.1

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      UniProtKB/TrEMBL
      B2R8R8
      Conserved Domains (4) summary
      cd08737
      Location:291 → 415
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:116 → 217
      RGS_DHEX; Regulator of G-protein signalling DHEX domain
      cl00069
      Location:258 → 285
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    6. NM_001204421.3 → NP_001191350.1  regulator of G-protein signaling 6 isoform 7

      See identical proteins and their annotated locations for NP_001191350.1

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      UniProtKB/TrEMBL
      B7Z2A0
      Conserved Domains (3) summary
      cd08737
      Location:291 → 415
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      cl00069
      Location:258 → 285
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    7. NM_001204422.3 → NP_001191351.1  regulator of G-protein signaling 6 isoform 8

      See identical proteins and their annotated locations for NP_001191351.1

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      UniProtKB/TrEMBL
      B2R8R8
      Conserved Domains (3) summary
      cd08737
      Location:291 → 415
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      cl00069
      Location:258 → 285
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    8. NM_001204423.2 → NP_001191352.1  regulator of G-protein signaling 6 isoform 9

      See identical proteins and their annotated locations for NP_001191352.1

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005533, AC005993
      Consensus CDS
      CCDS73655.1
      UniProtKB/TrEMBL
      A0A087WTW9, B7Z2N1
      Related
      ENSP00000383953.3, ENST00000402788.6
      Conserved Domains (3) summary
      smart00224
      Location:223 → 284
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:293 → 417
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:1 → 84
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    9. NM_001204424.2 → NP_001191353.1  regulator of G-protein signaling 6 isoform 1

      See identical proteins and their annotated locations for NP_001191353.1

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005993, AF107619, AF156932, AK294486, BC104877, BX096120, BX537512
      Consensus CDS
      CCDS55924.1
      UniProtKB/TrEMBL
      B7Z2A0
      Related
      ENSP00000451030.1, ENST00000553525.6
      Conserved Domains (4) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:116 → 217
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    10. NM_001370270.1 → NP_001357199.1  regulator of G-protein signaling 6 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      UniProtKB/TrEMBL
      B7Z2A0
      Conserved Domains (4) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:116 → 217
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    11. NM_001370271.1 → NP_001357200.1  regulator of G-protein signaling 6 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      UniProtKB/TrEMBL
      B7Z2A0
      Conserved Domains (4) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:116 → 217
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    12. NM_001370272.1 → NP_001357201.1  regulator of G-protein signaling 6 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      UniProtKB/TrEMBL
      B7Z2A0
      Conserved Domains (4) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:116 → 217
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    13. NM_001370273.1 → NP_001357202.1  regulator of G-protein signaling 6 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      UniProtKB/TrEMBL
      B7Z2A0
      Conserved Domains (4) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:116 → 217
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    14. NM_001370274.1 → NP_001357203.1  regulator of G-protein signaling 6 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      UniProtKB/TrEMBL
      B7Z2A0
      Conserved Domains (4) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:116 → 217
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    15. NM_001370275.1 → NP_001357204.1  regulator of G-protein signaling 6 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      Conserved Domains (4) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      PRK14963
      Location:417 → 606
      PRK14963; DNA polymerase III subunits gamma and tau; Provisional
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    16. NM_001370276.1 → NP_001357205.1  regulator of G-protein signaling 6 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      Conserved Domains (4) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      PRK14963
      Location:417 → 606
      PRK14963; DNA polymerase III subunits gamma and tau; Provisional
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    17. NM_001370277.1 → NP_001357206.1  regulator of G-protein signaling 6 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      UniProtKB/TrEMBL
      B7Z7N5, C9J109
      Related
      ENSP00000412144.2, ENST00000434263.6
      Conserved Domains (3) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    18. NM_001370278.1 → NP_001357207.1  regulator of G-protein signaling 6 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      UniProtKB/TrEMBL
      B7Z2A0
      Conserved Domains (3) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    19. NM_001370279.1 → NP_001357208.1  regulator of G-protein signaling 6 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      UniProtKB/TrEMBL
      B7Z2A0
      Conserved Domains (3) summary
      smart00224
      Location:255 → 316
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:325 → 449
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    20. NM_001370280.1 → NP_001357209.1  regulator of G-protein signaling 6 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      UniProtKB/TrEMBL
      B7Z2A0
      Conserved Domains (3) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      cl02565
      Location:321 → 410
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    21. NM_001370281.1 → NP_001357210.1  regulator of G-protein signaling 6 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      UniProtKB/TrEMBL
      B7Z2A0
      Conserved Domains (3) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    22. NM_001370282.1 → NP_001357211.1  regulator of G-protein signaling 6 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      UniProtKB/TrEMBL
      B7Z2A0
      Conserved Domains (3) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    23. NM_001370283.1 → NP_001357212.1  regulator of G-protein signaling 6 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      UniProtKB/TrEMBL
      B7Z2A0
      Conserved Domains (4) summary
      cd08737
      Location:291 → 415
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:116 → 217
      RGS_DHEX; Regulator of G-protein signalling DHEX domain
      cl00069
      Location:258 → 285
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    24. NM_001370284.1 → NP_001357213.1  regulator of G-protein signaling 6 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      Consensus CDS
      CCDS55924.1
      UniProtKB/TrEMBL
      B7Z2A0
      Conserved Domains (4) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:116 → 217
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    25. NM_001370286.1 → NP_001357215.1  regulator of G-protein signaling 6 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      UniProtKB/TrEMBL
      B7Z2A0
      Conserved Domains (2) summary
      cd08737
      Location:258 → 382
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    26. NM_001370287.1 → NP_001357216.1  regulator of G-protein signaling 6 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      Consensus CDS
      CCDS9808.1
      UniProtKB/Swiss-Prot
      C9JE95, F8W7W5, O75576, O75577, P49758, Q7Z4K3, Q7Z4K4, Q7Z4K5, Q7Z4K6, Q8TE13, Q8TE14, Q8TE15, Q8TE16, Q8TE17, Q8TE18, Q8TE19, Q8TE20, Q8TE21, Q8TE22, Q9UDS8, Q9UDT0, Q9Y245, Q9Y647
      UniProtKB/TrEMBL
      B2R8R8, Q2M3K2
      Related
      ENSP00000450936.1, ENST00000555571.5
      Conserved Domains (4) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:116 → 217
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    27. NM_001370288.1 → NP_001357217.1  regulator of G-protein signaling 6 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      Consensus CDS
      CCDS9808.1
      UniProtKB/Swiss-Prot
      C9JE95, F8W7W5, O75576, O75577, P49758, Q7Z4K3, Q7Z4K4, Q7Z4K5, Q7Z4K6, Q8TE13, Q8TE14, Q8TE15, Q8TE16, Q8TE17, Q8TE18, Q8TE19, Q8TE20, Q8TE21, Q8TE22, Q9UDS8, Q9UDT0, Q9Y245, Q9Y647
      UniProtKB/TrEMBL
      B2R8R8, Q2M3K2
      Conserved Domains (4) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:116 → 217
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    28. NM_001370289.1 → NP_001357218.1  regulator of G-protein signaling 6 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      Consensus CDS
      CCDS9808.1
      UniProtKB/Swiss-Prot
      C9JE95, F8W7W5, O75576, O75577, P49758, Q7Z4K3, Q7Z4K4, Q7Z4K5, Q7Z4K6, Q8TE13, Q8TE14, Q8TE15, Q8TE16, Q8TE17, Q8TE18, Q8TE19, Q8TE20, Q8TE21, Q8TE22, Q9UDS8, Q9UDT0, Q9Y245, Q9Y647
      UniProtKB/TrEMBL
      B2R8R8, Q2M3K2
      Conserved Domains (4) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:116 → 217
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    29. NM_001370290.1 → NP_001357219.1  regulator of G-protein signaling 6 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      Consensus CDS
      CCDS91897.1
      UniProtKB/TrEMBL
      B2R8R8
      Related
      ENSP00000450858.1, ENST00000554474.5
      Conserved Domains (4) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:116 → 217
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    30. NM_001370291.1 → NP_001357220.1  regulator of G-protein signaling 6 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      Consensus CDS
      CCDS91897.1
      UniProtKB/TrEMBL
      B2R8R8
      Conserved Domains (4) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:116 → 217
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    31. NM_001370292.1 → NP_001357221.1  regulator of G-protein signaling 6 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      UniProtKB/TrEMBL
      B2R8R8
      Conserved Domains (4) summary
      cd08737
      Location:291 → 415
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:116 → 217
      RGS_DHEX; Regulator of G-protein signalling DHEX domain
      cl00069
      Location:258 → 285
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    32. NM_001370293.1 → NP_001357222.1  regulator of G-protein signaling 6 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      UniProtKB/TrEMBL
      B2R8R8
      Conserved Domains (4) summary
      cd08737
      Location:291 → 415
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:116 → 217
      RGS_DHEX; Regulator of G-protein signalling DHEX domain
      cl00069
      Location:258 → 285
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    33. NM_001370294.1 → NP_001357223.1  regulator of G-protein signaling 6 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      UniProtKB/TrEMBL
      B2R8R8
      Conserved Domains (3) summary
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      cl00069
      Location:258 → 284
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors
      cl02565
      Location:285 → 373
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    34. NM_004296.7 → NP_004287.3  regulator of G-protein signaling 6 isoform 2

      See identical proteins and their annotated locations for NP_004287.3

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993
      Consensus CDS
      CCDS9808.1
      UniProtKB/Swiss-Prot
      C9JE95, F8W7W5, O75576, O75577, P49758, Q7Z4K3, Q7Z4K4, Q7Z4K5, Q7Z4K6, Q8TE13, Q8TE14, Q8TE15, Q8TE16, Q8TE17, Q8TE18, Q8TE19, Q8TE20, Q8TE21, Q8TE22, Q9UDS8, Q9UDT0, Q9Y245, Q9Y647
      UniProtKB/TrEMBL
      B2R8R8, Q2M3K2
      Related
      ENSP00000452331.1, ENST00000553530.5
      Conserved Domains (4) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:116 → 217
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    RNA

    1. NR_135235.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC004828, AC005157, AC005477, AC005533, AC005993

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      71867335..72630029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024449761.2 → XP_024305529.1  regulator of G-protein signaling 6 isoform X1

      Conserved Domains (3) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    2. XM_017021825.3 → XP_016877314.1  regulator of G-protein signaling 6 isoform X8

      UniProtKB/TrEMBL
      B7Z2A0
      Related
      ENSP00000384612.4, ENST00000407322.8

    3. XM_017021822.3 → XP_016877311.1  regulator of G-protein signaling 6 isoform X6

      UniProtKB/TrEMBL
      B7Z2A0

    4. XM_017021827.3 → XP_016877316.1  regulator of G-protein signaling 6 isoform X10

      UniProtKB/TrEMBL
      B7Z2A0

    5. XM_024449759.2 → XP_024305527.1  regulator of G-protein signaling 6 isoform X1

      Conserved Domains (3) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    6. XM_017021820.3 → XP_016877309.1  regulator of G-protein signaling 6 isoform X2

      Conserved Domains (3) summary
      cd08737
      Location:291 → 415
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      cl00069
      Location:258 → 285
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    7. XM_024449776.2 → XP_024305544.1  regulator of G-protein signaling 6 isoform X16

      UniProtKB/TrEMBL
      A0A0A0MRA9
      Conserved Domains (3) summary
      cd08737
      Location:291 → 415
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      cl00069
      Location:258 → 285
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    8. XM_047431987.1 → XP_047287943.1  regulator of G-protein signaling 6 isoform X7

      UniProtKB/TrEMBL
      B7Z2A0

    9. XM_017021826.3 → XP_016877315.1  regulator of G-protein signaling 6 isoform X9

      UniProtKB/TrEMBL
      B7Z2A0
      Related
      ENSP00000384218.4, ENST00000406236.8
      Conserved Domains (3) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    10. XM_017021830.3 → XP_016877319.1  regulator of G-protein signaling 6 isoform X13

      UniProtKB/TrEMBL
      B2R8R8
      Conserved Domains (4) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:116 → 217
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    11. XM_017021828.3 → XP_016877317.1  regulator of G-protein signaling 6 isoform X12

      UniProtKB/TrEMBL
      B2R8R8

    12. XM_047431990.1 → XP_047287946.1  regulator of G-protein signaling 6 isoform X17

      UniProtKB/TrEMBL
      B2R8R8

    13. XM_017021832.3 → XP_016877321.1  regulator of G-protein signaling 6 isoform X15

      UniProtKB/TrEMBL
      B2R8R8
      Related
      ENSP00000347699.6, ENST00000355512.10
      Conserved Domains (3) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    14. XM_017021831.3 → XP_016877320.1  regulator of G-protein signaling 6 isoform X14

      UniProtKB/TrEMBL
      B2R8R8

    15. XM_017021833.3 → XP_016877322.1  regulator of G-protein signaling 6 isoform X18

    16. XM_024449760.2 → XP_024305528.1  regulator of G-protein signaling 6 isoform X1

      Conserved Domains (3) summary
      smart00224
      Location:258 → 319
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:328 → 452
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:31 → 119
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    17. XM_024449764.2 → XP_024305532.1  regulator of G-protein signaling 6 isoform X4

      Conserved Domains (3) summary
      smart00224
      Location:189 → 250
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:259 → 383
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:1 → 50
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    18. XM_024449763.2 → XP_024305531.1  regulator of G-protein signaling 6 isoform X4

      Conserved Domains (3) summary
      smart00224
      Location:189 → 250
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:259 → 383
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein
      cd04450
      Location:1 → 50
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    19. XM_047431985.1 → XP_047287941.1  regulator of G-protein signaling 6 isoform X3

    20. XM_011537397.2 → XP_011535699.1  regulator of G-protein signaling 6 isoform X5

      See identical proteins and their annotated locations for XP_011535699.1

      Conserved Domains (2) summary
      smart00224
      Location:119 → 180
      GGL; G protein gamma subunit-like motifs
      cd08737
      Location:189 → 313
      RGS_RGS6; Regulator of G protein signaling (RGS) domain found in the RGS6 protein

    21. XM_047431988.1 → XP_047287944.1  regulator of G-protein signaling 6 isoform X11

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      66072765..66835660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377096.1 → XP_054233071.1  regulator of G-protein signaling 6 isoform X19

    2. XM_054377095.1 → XP_054233070.1  regulator of G-protein signaling 6 isoform X19

    3. XM_054377105.1 → XP_054233080.1  regulator of G-protein signaling 6 isoform X8

      UniProtKB/TrEMBL
      B7Z2A0

    4. XM_054377103.1 → XP_054233078.1  regulator of G-protein signaling 6 isoform X6

      UniProtKB/TrEMBL
      B7Z2A0

    5. XM_054377107.1 → XP_054233082.1  regulator of G-protein signaling 6 isoform X10

      UniProtKB/TrEMBL
      B7Z2A0

    6. XM_054377101.1 → XP_054233076.1  regulator of G-protein signaling 6 isoform X22

    7. XM_054377100.1 → XP_054233075.1  regulator of G-protein signaling 6 isoform X21

    8. XM_054377113.1 → XP_054233088.1  regulator of G-protein signaling 6 isoform X16

      UniProtKB/TrEMBL
      A0A0A0MRA9

    9. XM_054377099.1 → XP_054233074.1  regulator of G-protein signaling 6 isoform X20

    10. XM_054377104.1 → XP_054233079.1  regulator of G-protein signaling 6 isoform X24

      UniProtKB/TrEMBL
      B7Z2A0

    11. XM_054377110.1 → XP_054233085.1  regulator of G-protein signaling 6 isoform X13

      UniProtKB/TrEMBL
      B2R8R8

    12. XM_054377106.1 → XP_054233081.1  regulator of G-protein signaling 6 isoform X9

      UniProtKB/TrEMBL
      B7Z2A0

    13. XM_054377109.1 → XP_054233084.1  regulator of G-protein signaling 6 isoform X13

      UniProtKB/TrEMBL
      B2R8R8

    14. XM_054377114.1 → XP_054233089.1  regulator of G-protein signaling 6 isoform X17

      UniProtKB/TrEMBL
      B2R8R8

    15. XM_054377108.1 → XP_054233083.1  regulator of G-protein signaling 6 isoform X12

      UniProtKB/TrEMBL
      B2R8R8

    16. XM_054377112.1 → XP_054233087.1  regulator of G-protein signaling 6 isoform X15

      UniProtKB/TrEMBL
      B2R8R8

    17. XM_054377111.1 → XP_054233086.1  regulator of G-protein signaling 6 isoform X14

      UniProtKB/TrEMBL
      B2R8R8

    18. XM_054377115.1 → XP_054233090.1  regulator of G-protein signaling 6 isoform X18

    19. XM_054377102.1 → XP_054233077.1  regulator of G-protein signaling 6 isoform X23

      UniProtKB/TrEMBL
      B7Z2A0

    20. XM_054377097.1 → XP_054233072.1  regulator of G-protein signaling 6 isoform X19

    21. XM_054377098.1 → XP_054233073.1  regulator of G-protein signaling 6 isoform X20

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49758.5 GenPept UniProtKB/Swiss-Prot:P49758

    Gene LinkOut

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